Sedative and cardiorespiratory effects of medetomidine, medetomidine-butorphanol, and medetomidine-ketamine in dogs

Journal of the American Veterinary Medical Association

Volumn 216, Issue 10, 2000, Pages 1578-1583

  Ko, Jeff C H ^a,b   Fox, Steven M ^c   Mandsager, Ronald E ^b  

^a University of Florida College of Veterinary Medicine   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

^c ZOETIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

ATIPAMEZOLE; BUTORPHANOL; GLYCOPYRRONIUM BROMIDE; KETAMINE; MEDETOMIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTERIAL PH; ARTICLE; CARDIOPULMONARY INSUFFICIENCY; CONTROLLED STUDY; DOG; ENDOTRACHEAL INTUBATION; NONHUMAN; RECUMBENCY; SEDATION;

ADJUVANTS, ANESTHESIA; ADRENERGIC ALPHA-AGONISTS; ANALGESICS, OPIOID; ANESTHETICS, DISSOCIATIVE; ANIMALS; BLOOD PRESSURE; BUTORPHANOL; CROSS-OVER STUDIES; DOGS; DRUG COMBINATIONS; GLYCOPYRROLATE; HEART RATE; HYPNOTICS AND SEDATIVES; IMIDAZOLES; INJECTIONS, INTRAMUSCULAR; INTUBATION, INTRATRACHEAL; KETAMINE; MEDETOMIDINE; PAIN MEASUREMENT; RANDOM ALLOCATION; RESPIRATION;

EID: 0034657788     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2000.216.1578     Document Type: Article

References (16)

1. Ko JCH, McGrath CJ, Nicklin CF. Answers to your questions about medetomidine and atipamezole. Vet Med 1997;92: 415-425.
2. Cullen LK. Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J 1996;152:519-535.
3. Bartram DH, Diamond MJ, Tute AS, et al. Use of medetomidine and butorphanol for sedation in dogs. J Small Anim Pract 1994;35:495-498.
4. Ko JCH, Bailey JE, Pablo LS, et al. Comparison of sedative and cardiorespiratory effects of medetomidine and a medetomidine-butorphanol combination in dogs. Am J Vet Res 1996;57:535-540.
5. Moens Y, Fargetton X. A comparative study of medetomidine/ketamine and xylazine/ketamine anaesthesia in dogs. Vet Rec 1990;127:567-571.
6. Muir WW III, Ford JL, Karpa GE, et al. Effects of intramuscular administration of low doses of medetomidine and medetomidine-butorphanol in middle-aged and old dogs. J Am Vet Med Assoc 1999;215:1116-1120.
7. Hayashi K, Nishimura R, Yamaki A, et al. Comparison of sedative effects induced by medetomidine, medetomidine-midazolam, and medetomidine-butorphanol in dogs. J Vet Med Sci 1994;56:951-956.
8. Jalanka H, Skutnabb K, Damsten Y. Preliminary results on the use of medetomidine-ketamine combinations in the dog. Acta Vet Stand 1989;85:125-127.
9. SAS/IML software: usage and reference, version 6. Cary, NC: SAS Institute Inc. 1990.
10. Salonen JS. Pharmacokinetics of medetomidine. Acta Vet Scand 1989;85:49-54.
11. Tomizawa N, Tomita I, Nakamura K, et al. A comparative study of medetomidine-butorphanol-ketamine and medetomidine-ketamine anaesthesia in dogs. J Vet Med Sci 1997;44A:189-194.
12. Short CE. Effects of anticholinergic treatment on the cardiac and respiratory system in dogs sedated with medetomidine. Vet Rec 1991;129:310-313.
13. Alibhai HIK, Clarke KW, Lee YH, et al. Cardiopulmonary effects of combinations of medetomidine hydrochloride and atropine sulphate in dogs. Vet Rec 1996;138:11-13.
14. Serteyn D, Coppens P, Jones R, et al. Circulatory and respiratory effects of the combination medetomidine-ketamine in beagles. J Vet Pharmacol Ther 1993;16:199-206.
15. Verstegen J, Fargetton X, Ectors F. Medetomidine-ketamine anaesthesia in cats. Acta Vet Scand 1989;85:117-123.
16. Kaka JS, Hayton WL. Pharmacokinetics of ketamine and two metabolites in the dog. J Pharmacokinet Biopharm 1980;8:193-202.