Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine

American Journal of Veterinary Research

Volumn 66, Issue 7, 2005, Pages 1222-1226

  Grimm, Kurt A ^a   Tranquilli, William J ^a   Gross, David R ^a   Sisson, David D ^b   Bulmer, Barret J ^c   Benson, John ^a   Greene, Stephen A ^d   Martin Jimenez, Tomas ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b OREGON STATE UNIVERSITY   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

^d WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FENTANYL; MEDETOMIDINE; OXYGEN;

ANIMAL EXPERIMENT; ARTERIAL OXYGEN TENSION; ARTERIAL PRESSURE; ARTICLE; BLOOD GAS ANALYSIS; BLOOD SAMPLING; BODY WEIGHT; BOLUS INJECTION; CONSCIOUSNESS; CONTINUOUS INFUSION; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG INFUSION; DRUG SAFETY; HEART FUNCTION; HEART HEMODYNAMICS; HEART INDEX; HEART LEFT ATRIUM PRESSURE; HEART OUTPUT; HEART RATE; HEMODYNAMIC PARAMETERS; LUNG FUNCTION; LUNG HEMODYNAMICS; MALE; NONHUMAN; OXYGEN TRANSPORT; PULMONARY ARTERY; SEDATION;

ANALGESICS; ANIMALS; BLOOD PRESSURE; DOGS; DRUG INTERACTIONS; FENTANYL; HEART RATE; MALE; MEDETOMIDINE; OXYGEN CONSUMPTION; STROKE VOLUME; VASCULAR RESISTANCE;

ANIMALIA; CANIS FAMILIARIS;

EID: 23844450466     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.1222     Document Type: Article

References (23)

1. Meert TF, De Kock M. Potentiation of the analgesic properties of fentanyl-like opioids with alpha 2-adrenoceptor agonists in rats. Anesthesiology 1994;81:677-688.
2. Grimm KA, Tranquilli WJ, Thurmon JC, et al. Duration of non-response to noxious stimulation after intramuscular administration of butorphanol, medetomidine, or a butorphanol-medetomidine combination during isoflurane administration in dogs. Am J Vet Res 2000;61:42-47.
3. Cullen LK. Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J 1996;152:519-535.
4. Benson GJ, Thurmon JC, Tranquilli WJ, et al Cardiopulmonary effects of an intravenous infusion of guaifenesin, ketamine, and xylazine in dogs. Am J Vet Res 1985;46:1896-1898.
5. Tranquilli WJ, Grimm KA, Lamont LA. Pain management for the small animal practitioner. 2nd ed. Jackson, Wyo: Teton New Media, 2004.
6. Willigers HM, Prinzen FW, Roekaerts PM, et al. Dexmedetomidine decreases perioperative myocardial lactate release in dogs. Anesth Analg 2003;96:657-664.
7. Lawrence CJ, Prinzen FW, de Lange S. The effect of dexmedetomidine on nutrient organ blood flow. Anesth Analg 1996;83:1160-1165.
8. Pypendop BH, Verstegen JP. Hemodynamic effects of medetomidine in the dog: a dose titration study. Vet Surg 1998;27:612-622.
9. Klide AM, Calderwood HW, Soma LR. Cardiopulmonary effects of xylazine in dogs. Am J Vet Res 1975;36:931-935.
10. Phillips HR, Stack RS, Rembert JC, et al. A technique to inject microspheres into the left atrium of awake dogs without thoracotomy. Am J Physiol 1982;243:H488-H490.
11. Glantz SA, Slinker BK. Two-way analysis of variance. In: Primer of applied regression and analysis of variance. New York: McGraw-Hill Book Co, 2000;339-507.
12. Lamont LA, Bulmer BJ, Grimm KA, et al. Cardiopulmonary evaluation of the use of medetomidine hydrochloride in cats. Am J Vet Res 2001;62:1745-1749.
13. Jalonen J, Halkola L, Kuttila K, et al. Effects of dexmedetomidine on coronary hemodynamics and myocardial oxygen balance. J Cardiothorac Vasc Anesth 1995;9:519-524.
14. Flacke WE, Flacke JW, Bloor BC, et al. Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog. J Cardiothorac Vasc Anesth 1993;7:41-49.
15. Bloor BC, Frankland M, Alper G, et al. Hemodynamic and sedative effects of dexmedetomidine in dog. J Pharmacol Exp Ther 1992;263:690-697.
16. Weitz JD, Foster SD, Waugaman WR, et al. Anesthetic and hemodynamic effects of dexmedetomidine during isoflurane anesthesia in a canine model. Nurse Anesth 1991;2:19-27.
17. Flacke JW, Flacke WE, Bloor BC, et al. Hemodynamic effects of dexmedetomidine, an alpha 2-adrenergic agonist, in autonomically denervated dogs. J Cardiovasc Pharmacol 1990;16:616-623.
18. Reitan JA, Stengert KB, Wymore ML, et al. Central vagal control of fentanyl-induced bradycardia during halothane anesthesia. Anesth Analg 1978;57:31-36.
19. Inoue K, Samodelov LF, Arndt JO. Fentanyl activates a particular population of vagal efferents which are cardioinhibitory. Naunyn Schmiedebergs Arch Pharmacol 1980;312:57-61.
20. Gautret B, Schmitt H. Multiple sites for the cardiovascular actions of fentanyl in rats. J Cardiovasc Pharmacol 1985; 7:649-652.
21. Salmenpera MT, Szlam F, Hug CCJ. Anesthetic and hemodynamic interactions of dexmedetomidine and fentanyl in dogs. Anesthesiology 1994;80:837-846.
22. Copland VS, Haskins SC, Patz JD. Oxymorphone: cardiovascular, pulmonary, and behavioral effects in dogs. Am J Vet Res 1987;48:1626-1630.
23. Stoelting PK. Pulmonary circulation. In: Pharmacology and physiology in anesthetic practice. 2nd ed. Philadelphia: JB Lippincott Co, 1991;685-691.