Platelet transfusions: Trigger, dose, benefits, and risks

F1000 Medicine Reports

Volumn 2, Issue 1, 2010, Pages

  Blumberg, Neil ^a   Heal, Joanna M ^a   Phillips, Gordon L ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIBODY;

ACUTE LUNG INJURY; APHERESIS; BLEEDING; CLINICAL PRACTICE; CLINICAL TRIAL; HEMOLYSIS; HUMAN; LEUKEMIA; RECURRENT DISEASE; REFRACTORY PERIOD; REVIEW; RISK FACTOR; SEPSIS; SURGICAL TECHNIQUE; THROMBOCYTE TRANSFUSION; THROMBOSIS; TREATMENT INDICATION; TREATMENT OUTCOME;

EID: 77955063505     PISSN: None     EISSN: 17575931     Source Type: Journal    
DOI: 10.3410/M2-5     Document Type: Review

References (28)

1. Brand A, Novotny V, Tomson B: Platelet transfusion therapy: from 1973 to 2005. Hum Immunol 2006, 67:413-8.
2. Slichter SJ: Platelet transfusion therapy. Hematol Oncol Clin North Am 2007, 21:697-729, vii.
3. Heal JM, Blumberg N: Optimizing platelet transfusion therapy. Blood Rev 2004, 18:149-65.
4. Slichter SJ: Background, rationale, and design of a clinical trial to assess the effects of platelet dose on bleeding risk in thrombocytopenic patients. J Clin Apher 2006, 21:78-84.
5. Sadani DT, Urbaniak SJ, Bruce M, Tighe JE: Repeat ABOincompatible platelet transfusions leading to haemolytic transfusion reaction. Transfus Med 2006, 16:375-9.
6. Sapatnekar S, Sharma G, Downes KA, Wiersma S, McGrath C, Yomtovian R: Acute hemolytic transfusion reaction in a pediatric patient following transfusion of apheresis platelets. J Clin Apher 2005, 20:225-9.
7. Josephson CD, Mullis NC, Van Demark C, Hillyer CD: Significant numbers of apheresis-derived group O platelet units have "high-titer" anti-A/A,B: implications for transfusion policy. Transfusion 2004, 44:805-8.
8. The Trial to Reduce Alloimmunization to Platelets Study Group: Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. N Engl J Med 1997, 337:1861-9.
9. Heal JM, Rowe JM, McMican A, Masel D, Finke C, Blumberg N: The role of ABO matching in platelet transfusion. Eur J Haematol 1993, 50:110-7.
10. Vo TD, Cowles J, Heal JM, Blumberg N: Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions. Transfus Med 2001, 11:45-7.
11. Blumberg N, Heal JM, Rowe JM: A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia [ISRCTN76536440]. BMC Blood Disord 2004, 4:6.
12. Lawrence JB, Yomtovian RA, Hammons T, Masarik SR, Chongkolwatana V, Creger RJ, Manka A, Lazarus HM: Lowering the prophylactic platelet transfusion threshold: A prospective analysis. Leuk Lymphoma 2001, 41:67-76.
13. Rebulla P, Finazzi G, Marangoni F, Avvisati G, Gugliotta L, Tognoni G, Barbui T, Mandelli F, Sirchia G: The threshold for prophylactic platelet transfusions in adults with acute myeloid leukemia. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto. N Engl J Med 1997, 337:1870-5.
14. Wandt H, Frank M, Ehninger G, Schneider C, Brack N, Daoud A, Fackler-Schwalbe I, Fischer J, Gäckle R, Geer T, Harms P, Löffler B, Ohl S, Otremba B, Raab M, Schönrock-Nabulsi P, Strobel G, Winter R, Link H: Safety and cost effectiveness of a 10 × 10(9)/l trigger for prophylactic platelet transfusions compared with the traditional 20 × 10(9)/l trigger - a prospective comparative trial in 105 patients with acute myeloid leukemia. Blood 1998, 91:3601-6.
15. Kerkhoffs JL, Eikenboom JC, van de Watering LM, van Wordragen- Vlaswinkel RJ, Wijermans PW, Brand A: The clinical impact of platelet refractoriness: correlation with bleeding and survival. Transfusion 2008, 48:1959-65.
16. Wandt H, Schaefer-Eckart K, Frank M, Birkmann J, Wilhelm M: A therapeutic platelet transfusion strategy is safe and feasible in patients after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2006, 37:387-92.
17. Spiess BD, Royston D, Levy JH, Fitch J, Dietrich W, Body S, Murkin J, Nadel A: Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion 2004, 44:1143-8.
18. Pereboom IT, de Boer MT, Haagsma EB, Hendriks HG, Lisman T, Porte RJ: Platelet transfusion during liver transplantation is associated with increased postoperative mortality due to acute lung injury. Anesth Analg 2009, 108:1083-91.
19. Rogers MA, Blumberg N, Heal JM, Hicks GL Jr: Increased risk of infection and mortality in women after cardiac surgery related to allogeneic blood transfusion. J Womens Health (Larchmt) 2007, 16:1412-20.
20. Brecher ME, Means N, Jere CS, Heath D, Rothenberg S, Stutzman LC: Evaluation of an automated culture system for detecting bacterial contamination of platelets: an analysis with 15 contaminating organisms. Transfusion 2001, 41:477-82.
21. Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP: The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res 2009, [Epub ahead of print].
22. McMorran BJ, Marshall VM, de Graaf C, Drysdale KE, Shabbar M, Smyth GK, Corbin JE, Alexander WS, Foote SJ: Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 2009, 323:797-800.
23. Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH: Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med 2008, 168:2377-81.
24. Heal JM, Liesveld JL, Phillips GL, Blumberg N: What would Karl Landsteiner do? The ABO blood group and stem cell transplantation. Bone Marrow Transplant 2005, 36:747-55.
25. Wagner DD: New links between inflammation and thrombosis. Arterioscler Thromb Vasc Biol 2005, 25:1321-4.
26. Blumberg N, Gettings KF, Turner C, Heal JM, Phipps RP: An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions. Transfusion 2006, 46:1813-21.
27. Cognasse F, Boussoulade F, Chavarin P, Acquart S, Fabrigli P, Lamy B, Garraud O: Release of potential immunomodulatory factors during platelet storage. Transfusion 2006, 46:1184-9.
28. Sprague DL, Elzey BD, Crist SA, Waldschmidt TJ, Jensen RJ, Ratliff TL: Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 2008, 111:5028-36.