The platelet as an immune cell-CD40 ligand and transfusion immunomodulation

Immunologic Research

Volumn 45, Issue 2-3, 2009, Pages 251-260

  Blumberg, Neil ^a   Spinelli, Sherry L ^a   Francis, Charles W ^a   Taubman, Mark B ^a   Phipps, Richard P ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

CD154; CD40L; Immunity; Inflammation; Platelet; Transfusion

Indexed keywords

CD40 LIGAND;

ACUTE LEUKEMIA; ACUTE LUNG INJURY; ADAPTIVE IMMUNITY; B LYMPHOCYTE; BLOOD TRANSFUSION; CELL MATURATION; CYTOLOGY; FEVER; HEMOSTASIS; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INFLAMMATION; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RIGOR; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION; THROMBOCYTE TRANSFUSION; VEIN THROMBOSIS;

ADAPTIVE IMMUNITY; ANTIGENS, CD40; BLOOD PLATELETS; CD40 LIGAND; CYTOKINES; HUMANS; IMMUNITY, INNATE; IMMUNOMODULATION; PLATELET TRANSFUSION;

EID: 72449129650     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-009-8106-9     Document Type: Review

References (58)

1. V Henn JR Slupsky M Grafe I Anagnostopoulos R Forster G Muller-Berghaus RA Kroczek 1998 CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells Nature 391 591 594 10.1038/35393 1:CAS:528:DyaK1cXhtVSlsb8%3D 9468137 (Pubitemid 28157601)
2. J Banchereau F Briere C Caux J Davoust S Lebecque YJ Liu B Pulendran K Palucka 2000 Immunobiology of dendritic cells Annu Rev Immunol 18 767 811 10.1146/annurev.immunol.18.1.767 1:CAS:528:DC%2BD3cXjs1GmtrY%3D 10837075 (Pubitemid 30365397)
3. MR Kehry 1996 CD40-mediated signaling in B cells. Balancing cell survival, growth, and death J Immunol 156 2345 2348 1:CAS:528:DyaK28XhvVGlsb4%3D 8786287
4. H Xu X Zhang RB Mannon AD Kirk 2006 Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154 J Clin Invest 116 769 774 10.1172/JCI27155 1:CAS:528:DC%2BD28XitlGktbo%3D 16498500 (Pubitemid 43326886)
5. L Graca K Honey E Adams SP Cobbold H Waldmann 2000 Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance J Immunol 165 4783 4786 1:CAS:528:DC%2BD3cXnvVOgu7s%3D 11045999
6. DD Wagner 2005 New links between inflammation and thrombosis Arterioscler Thromb Vasc Biol 25 1321 1324 10.1161/01.ATV.0000166521.90532.44 1:CAS:528:DC%2BD2MXltlSju7g%3D 15831808 (Pubitemid 40923346)
7. P Andre L Nannizzi-Alaimo SK Prasad DR Phillips 2002 Platelet-derived CD40L: the switch-hitting player of cardiovascular disease Circulation 106 896 899 10.1161/01.CIR.0000028962.04520.01 12186789 (Pubitemid 34925319)
8. GD Sempowski PR Chess RP Phipps 1997 CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts J Immunol 158 4670 4677 1:CAS:528:DyaK2sXjtFGltrg%3D 9144479
9. SY Khan MR Kelher JM Heal N Blumberg LK Boshkov R Phipps KF Gettings NJ McLaughlin CC Silliman 2006 Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury Blood 108 2455 2462 10.1182/blood-2006-04-017251 1:CAS:528:DC%2BD28XhtVCgur3M 16772606 (Pubitemid 44497533)
10. AA Gaspari GD Sempowski P Chess J Gish RP Phipps 1996 Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism Eur J Immunol 26 1371 1377 10.1002/eji.1830260629 1:CAS:528:DyaK28Xks1egtLw%3D 8647219 (Pubitemid 26001075)
11. DP Inwald A McDowall MJ Peters RE Callard NJ Klein 2003 CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation Circ Res 92 1041 1048 10.1161/01.RES.0000070111.98158.6C 1:CAS:528:DC%2BD3sXjsVGqt7Y%3D 12676820 (Pubitemid 36588504)
12. S Danese C Fiocchi 2005 Platelet activation and the CD40/CD40 ligand pathway: mechanisms and implications for human disease Crit Rev Immunol 25 103 121 10.1615/CritRevImmunol.v25.i2.20 1:CAS:528:DC%2BD2sXktleit7Y%3D 15952932 (Pubitemid 40910584)
13. JR Slupsky M Kalbas A Willuweit V Henn RA Kroczek G Muller-Berghaus 1998 Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40 Thromb Haemost 80 1008 1014 1:CAS:528:DyaK1cXotVSlsLw%3D 9869175
14. F Cognasse H Hamzeh P Chavarin S Acquart C Genin O Garraud 2005 Evidence of Toll-like receptor molecules on human platelets Immunol Cell Biol 83 196 198 10.1111/j.1440-1711.2005.01314.x 1:CAS:528:DC%2BD2MXjsV2qs7s%3D 15748217 (Pubitemid 40469328)
15. G Andonegui SM Kerfoot K McNagny KV Ebbert KD Patel P Kubes 2005 Platelets express functional Toll-like receptor-4 Blood 106 2417 2423 10.1182/blood-2005-03-0916 1:CAS:528:DC%2BD2MXhtVKqt7zF 15961512 (Pubitemid 41510815)
16. R Shiraki N Inoue S Kawasaki A Takei M Kadotani Y Ohnishi J Ejiri S Kobayashi K Hirata S Kawashima M Yokoyama 2004 Expression of Toll-like receptors on human platelets Thromb Res 113 379 385 10.1016/j.thromres.2004.03.023 1:CAS:528:DC%2BD2cXlt1ahu7g%3D 15226092 (Pubitemid 38844368)
17. SR Clark AC Ma SA Tavener B McDonald Z Goodarzi MM Kelly KD Patel S Chakrabarti E McAvoy GD Sinclair EM Keys E Allen-Vercoe R Devinney CJ Doig FH Green P Kubes 2007 Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood Nat Med 13 463 469 10.1038/nm1565 1:CAS:528:DC%2BD2sXjvVaqur0%3D 17384648 (Pubitemid 46559832)
18. P Vanichakarn P Blair C Wu JE Freedman S Chakrabarti 2008 Neutrophil CD40 enhances platelet-mediated inflammation Thromb Res 122 346 358 10.1016/j.thromres.2007.12.019 1:CAS:528:DC%2BD1cXotlWqs7Y%3D 18289643
19. BD Elzey JF Grant HW Sinn B Nieswandt TJ Waldschmidt TL Ratliff 2005 Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation J Leukoc Biol 78 80 84 10.1189/jlb.1104669 1:CAS:528:DC%2BD2MXmtFKnsLw%3D 15899982 (Pubitemid 40979946)
20. BD Elzey NW Schmidt SA Crist TP Kresowik JT Harty B Nieswandt TL Ratliff 2008 Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge Blood 111 3684 3691 10.1182/blood-2007-05- 091728 1:CAS:528:DC%2BD1cXktlWmtr4%3D 18256321
21. A Solanilla JM Pasquet JF Viallard C Contin C Grosset J Dechanet-Merville M Dupouy M Landry F Belloc P Nurden P Blanco JF Moreau JL Pellegrin AT Nurden J Ripoche 2005 Platelet-associated CD154 in immune thrombocytopenic purpura Blood 105 215 218 10.1182/blood-2003-07-2367 1:CAS:528:DC%2BD2MXis1Gqtg%3D%3D 15191945 (Pubitemid 40053085)
22. F Cognasse P Chavarin S Acquart O Sabido L Beniguel C Genin Y Richard O Garraud 2005 Differential downstream effects of CD40 ligation mediated by membrane or soluble CD40L and agonistic Ab: a study on purified human B cells Int J Immunopathol Pharmacol 18 65 74 1:CAS:528:DC%2BD2MXjtlaktLs%3D 15698512
23. F Cognasse H Hamzeh-Cognasse S Lafarge P Chavarin M Cogne Y Richard O Garraud 2007 Human platelets can activate peripheral blood B cells and increase production of immunoglobulins Exp Hematol 35 1376 1387 10.1016/j.exphem.2007.05. 021 1:CAS:528:DC%2BD2sXpvF2ktLY%3D 17656005 (Pubitemid 47302591)
24. DL Sprague BD Elzey SA Crist TJ Waldschmidt RJ Jensen TL Ratliff 2008 Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles Blood 111 5028 5036 10.1182/blood-2007-06-097410 1:CAS:528:DC%2BD1cXmtlahsr4%3D 18198347
25. DL Sprague JM Sowa BD Elzey TL Ratliff 2007 The role of platelet CD154 in the modulation in adaptive immunity Immunol Res 39 185 193 10.1007/s12026-007- 0074-3 1:CAS:528:DC%2BD2sXhtlertbbP 17917065 (Pubitemid 47574885)
26. Francis CW, Kaplan KL. Principles of antithrombotic therapy. In: Lichtman MA, et al., editors. Williams hematology. 7th ed. New York: McGraw-Hill; 2006. p. 283-300.
27. P Andre KS Prasad CV Denis M He JM Papalia RO Hynes DR Phillips DD Wagner 2002 CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism Nat Med 8 247 252 10.1038/nm0302-247 1:CAS:528:DC%2BD38Xit1equ7k%3D 11875495 (Pubitemid 34250102)
28. KS Prasad P Andre M He M Bao J Manganello DR Phillips 2003 Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling Proc Natl Acad Sci USA 100 12367 12371 10.1073/pnas.2032886100 1:CAS:528:DC%2BD3sXotlGksLc%3D 14519852 (Pubitemid 37271566)
29. R Pluvinet R Olivar J Krupinski I Herrero-Fresneda A Luque J Torras JM Cruzado JM Grinyo L Sumoy JM Aran 2008 CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling Blood 112 3624 3637 10.1182/blood-2008-03-143305 1:CAS:528:DC%2BD1cXhtlCntrvM 18669876
30. RP Phipps 2008 CD40: Lord of the endothelial cell Blood 112 3531 3532 10.1182/blood-2008-08-175034 1:CAS:528:DC%2BD1cXhtlCntrzF 18948578
31. C Chen H Chai X Wang J Jiang MS Jamaluddin D Liao Y Zhang H Wang U Bharadwaj S Zhang M Li P Lin Q Yao 2008 Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells Blood 112 3205 3216 10.1182/blood-2008-03-143479 1:CAS:528:DC%2BD1cXht1Omur%2FK 18658029
32. MM Donners L Beckers D Lievens I Munnix J Heemskerk BJ Janssen E Wijnands J Cleutjens A Zernecke C Weber CL Ahonen U Benbow AC Newby RJ Noelle MJ Daemen E Lutgens 2008 The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling Blood 111 4596 4604 10.1182/blood-2007-05-088906 1:CAS:528:DC%2BD1cXlsVSrsrY%3D 18195092
33. KS Prasad P Andre Y Yan DR Phillips 2003 The platelet CD40L/GP IIb-IIIa axis in atherothrombotic disease Curr Opin Hematol 10 356 361 10.1097/00062752-200309000-00006 1:CAS:528:DC%2BD2cXkvFGksA%3D%3D 12913790 (Pubitemid 36936607)
34. N Varo D Vicent P Libby R Nuzzo AL Calle-Pascual MR Bernal A Fernandez-Cruz A Veves P Jarolim JJ Varo A Goldfine E Horton U Schonbeck 2003 Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones Circulation 107 2664 2669 10.1161/01.CIR.0000074043.46437.44 1:CAS:528:DC%2BD3sXjvFKjurw%3D 12742991
35. P Pignatelli V Sanguigni L Lenti L Loffredo R Carnevale R Sorge F Violi 2007 Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia: effect of atorvastatin J Thromb Haemost 5 1170 1178 10.1111/j.1538-7836.2007.02533.x 1:CAS:528:DC%2BD2sXntl2ksbw%3D 17388962 (Pubitemid 46902118)
36. SP Lee KI Ataga EP Orringer DR Phillips LV Parise 2006 Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammation Arterioscler Thromb Vasc Biol 26 1626 1631 10.1161/01.ATV.0000220374.00602.a2 1:CAS:528:DC%2BD28XmvFyjurc%3D 16601237 (Pubitemid 44288993)
37. D Aldinucci D Poletto P Nanni M Degan M Rupolo A Pinto V Gattei 2002 CD40L induces proliferation, self-renewal, rescue from apoptosis, and production of cytokines by CD40-expressing AML blasts Exp Hematol 30 1283 1292 10.1016/S0301-472X(02)00921-9 1:CAS:528:DC%2BD38XosFCjsrY%3D 12423681 (Pubitemid 35287581)
38. S Willimott M Baou K Naresh SD Wagner 2007 CD154 induces a switch in pro-survival Bcl-2 family members in chronic lymphocytic leukaemia Br J Haematol 138 721 732 10.1111/j.1365-2141.2007.06717.x 1:CAS:528:DC%2BD2sXhtFCksrfF 17760804 (Pubitemid 47313210)
39. Blumberg N, Heal JM. Transfusion immunomodulation. In: Hillyer CD, Silberstein LE, Ness PM, Anderson KC, Roback JD, editors. Blood banking and transfusion medicine. 2nd ed. Philadelphia, PA: Churchill Livingstone Elsevier; 2007. p. 701-12.
40. D Cook M Crowther M Meade C Rabbat L Griffith D Schiff W Geerts G Guyatt 2005 Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors Crit Care Med 33 1565 1571 10.1097/01.CCM.0000171207.95319.B2 16003063 (Pubitemid 40980613)
41. Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai M, Lyman GH. Blood transfusions, thrombosis and mortality in hospitalized cancer patients. Arch Intern Med. 2008;168:2377-81.
42. BD Spiess D Royston JH Levy J Fitch W Dietrich S Body J Murkin A Nadel 2004 Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes Transfusion 44 1143 1148 10.1111/j.1537-2995.2004.03322.x 15265117 (Pubitemid 38989746)
43. AB Kenton S Hegemier EO Smith DJ O'Donovan ML Brandt DL Cass MA Helmrath K Washburn EK Weihe CJ Fernandes 2005 Platelet transfusions in infants with necrotizing enterocolitis do not lower mortality but may increase morbidity J Perinatol 25 173 177 10.1038/sj.jp.7211237 15578029 (Pubitemid 40458283)
44. RP Phipps J Kaufman N Blumberg 2001 Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion Lancet 357 2023 2024 10.1016/S0140-6736(00) 05108-4 1:CAS:528:DC%2BD3MXks1Oisbo%3D 11438137 (Pubitemid 32592392)
45. N Blumberg RP Phipps J Kaufman JM Heal 2003 The causes and treatment of reactions to platelet transfusions Transfusion 43 291 292 10.1046/j.1537-2995. 2003.t01-2-00362.x 12559029 author reply 2 (Pubitemid 36207313)
46. N Blumberg KF Gettings C Turner JM Heal RP Phipps 2006 An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions Transfusion 46 1813 1821 10.1111/j.1537-2995.2006.00979.x 1:CAS:528: DC%2BD28Xht1SqsL3J 17002639 (Pubitemid 44435735)
47. J Kaufman SL Spinelli E Schultz N Blumberg RP Phipps 2007 Release of biologically active CD154 during collection and storage of platelet concentrates prepared for transfusion J Thromb Haemost 5 788 796 10.1111/j.1538-7836.2007. 02412.x 1:STN:280:DC%2BD2s3gtV2ltg%3D%3D 17403203 (Pubitemid 46563579)
48. N Blumberg JM Heal JM Rowe 2004 A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia [ISRCTN76536440] BMC Blood Disord 4 6 10.1186/1471-2326-4-6 15588315 (Pubitemid 40230483)
49. N Blumberg JM Heal JL Liesveld GL Phillips JM Rowe 2008 Platelet transfusion and survival in adults with acute leukemia Leukemia 22 631 635 10.1038/sj.leu.2404920 1:STN:280:DC%2BD1c7nsVenug%3D%3D 17805333
50. F Cognasse F Boussoulade P Chavarin S Acquart P Fabrigli B Lamy O Garraud 2006 Release of potential immunomodulatory factors during platelet storage Transfusion 46 1184 1189 10.1111/j.1537-2995.2006.00869.x 1:CAS:528: DC%2BD28XnsFarur4%3D 16836566 (Pubitemid 44139493)
51. A Skripchenko J Kurtz G Moroff SJ Wagner 2008 Platelet products prepared by different methods of sedimentation undergo platelet activation differently during storage Transfusion 48 1469 1477 10.1111/j.1537-2995.2008.01733.x 18482181
52. MA Rogers N Blumberg JM Heal GL Hicks Jr 2007 Increased risk of infection and mortality in women after cardiac surgery related to allogeneic blood transfusion J Womens Health (Larchmt) 16 1412 1420 10.1089/jwh.2007.0397 (Pubitemid 350233100)
53. J Aiboshi EE Moore CJ Ciesla CC Silliman 2001 Blood transfusion and the two-insult model of post-injury multiple organ failure Shock 15 302 306 10.1097/00024382-200115040-00009 1:STN:280:DC%2BD3Mvnt12qsA%3D%3D 11303730
54. SV Rao JG Jollis RA Harrington CB Granger LK Newby PW Armstrong DJ Moliterno L Lindblad K Pieper EJ Topol JS Stamler RM Califf 2004 Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes JAMA 292 1555 1562 10.1001/jama.292.13.1555 1:CAS:528: DC%2BD2cXot1aks7Y%3D 15467057 (Pubitemid 39314961)
55. JC Paglino GJ Pomper GS Fisch MH Champion EL Snyder 2004 Reduction of febrile but not allergic reactions to RBCs and platelets after conversion to universal prestorage leukoreduction Transfusion 44 16 24 10.1046/j.0041-1132. 2004.00608.x 14692962 (Pubitemid 38177131)
56. TD Vo J Cowles JM Heal N Blumberg 2001 Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions Transfus Med 11 45 47 10.1046/j.1365-3148.2001.00280.x 1:STN:280:DC%2BD3MvjsVeksg%3D%3D 11328571 (Pubitemid 32180321)
57. SA Kirkley J Cowles VD Pellegrini Jr CM Harris AD Boyd N Blumberg 1995 Cytokine secretion after allogeneic or autologous blood transfusion Lancet 345 527 10.1016/S0140-6736(95)90627-4 1:STN:280:DyaK2M7msF2ntA%3D%3D 7861907
58. GF Babcock JW Alexander 1996 The effects of blood transfusion on cytokine production by TH1 and TH2 lymphocytes in the mouse Transplantation 61 465 468 10.1097/00007890-199602150-00026 1:STN:280:DyaK287ptFSgtQ%3D%3D 8610362 (Pubitemid 26067926)