The threshold for prophylactic platelet transfusion in adults with acute myeloid leukemia

New England Journal of Medicine

Volumn 337, Issue 26, 1997, Pages 1870-1875

  Rebulla, Paolo ^a,f   Finazzi, Guido ^b   Marangoni, Francesca ^a   Avvisati, Giuseppe ^c   Gugliotta, Luigi ^d   Tognoni, Gianni ^e   Barbui, Tiziano ^b   Mandelli, Franco ^c   Sirchia, Glrolamo ^a  

^a Ctro Trasfusionale Immunol T   (Italy)

^b OSPEDALI RIUNITI   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^f FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; ETOPOSIDE; IDARUBICIN; MITOXANTRONE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING TENDENCY; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TREATMENT INDICATION;

ADOLESCENT; ADULT; AGED; FEMALE; HEMORRHAGE; HUMANS; LEUKEMIA, MYELOID; MALE; MIDDLE AGED; PLATELET TRANSFUSION; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 0031452585     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199712253372602     Document Type: Article

References (28)

1. Heyman MR, Schiffer CA. Platelet transfusion to patients receiving chemotherapy. In: Rossi EC, Simon TL, Moss GS, Gould SA, eds. Principles of transfusion medicine. 2nd ed. Baltimore: Williams & Wilkins, 1996:263-73.
2. Slichter SJ. Principles of platelet transfusion therapy. In: Hoffman R, Benz EJ Jr, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, eds. Hematology: basic principles and practice. 2nd ed. New York: Churchill Livingstone, 1995:1987-2006.
3. Dodd RY. The risk of transfusion-transmitted infection. N Engl J Med 1992;327:419-21.
4. Anderson KC, Weinstein HJ. Transfusion-associated graft-versus-host disease. N Engl J Med 1990;323:315-21. [Erratum, N Engl J Med 1990; 323:1360.]
5. National Institutes of Health Consensus Conference. Platelet transfusion therapy. Transfus Med Rev 1987;1:195-200.
6. Pisciotto PT, Benson K, Hume H, et al. Prophylactic versus therapeutic platelet transfusion practices in hematology and/or oncology patients. Transfusion 1995;35:498-502.
7. Gmür J, Burger J, Schanz U, Fehr J, Schaffner A. Safety of stringent prophylactic platelet transfusion policy for patients with acute leukaemia. Lancet 1991;338:1223-6.
8. Heckman KD, Weiner GJ, Davis CS, Strauss RG, Jones MP, Burns CP. Randomized study of prophylactic platelet transfusion threshold during induction therapy for adult acute leukemia: 10,000/μL versus 20,000/μL. J Clin Oncol 1997;15:1143-9.
9. Beutler E. Platelet transfusions: the 20,000/μL trigger. Blood 1993;81: 1411-3.
10. Kelleher JF. When to give platelet transfusions. Blood 1993;82:682.
11. Beutler E. When to give platelet transfusions. Blood 1993;82:683.
12. Sample size. In: Friedman LM, Furberg CD, DeMets DL. Fundamentals of clinical trials. 2nd ed. Littleton, Mass.: PSG Publishing, 1985:83-107.
13. Miller AB, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer 1981;47:207-14.
14. Slichter SJ, Harker LA. Preparation and storage of platelet concentrates. I. Factors influencing the harvest of viable platelets from whole blood. Br J Haematol 1976;34:395-402.
15. Bertolini F, Rebulla P, Riccardi D, Cortellaro M, Ranzi ML, Sirchia G. Evaluation of platelet concentrates prepared from buffy coats and stored in a glucose-free crystalloid medium. Transfusion 1989;29:605-9.
16. Gardner MJ, Altman DG. Statistics with confidence - confidence intervals and statistical guidelines. London: British Medical Journal, 1989.
17. Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials: the CONSORT statement. JAMA 1996; 276:637-9.
18. Slichter SJ, Harker LA. Thrombocytopenia: mechanisms and management of detects in platelet production. Clin Haematol 1978;7:523-39.
19. Heyman MR, Schiffer CA. Platelet transfusion therapy for the cancer patient. Semin Oncol 1990;17:198-209.
20. Wallace EL, Churchill WH, Surgenor DM, et al. Collection and transfusion of blood and blood components in the United States, 1992. Transfusion 1995;35:802-12.
21. McCullough J, Steeper TA, Connelly DP, Jackson B, Huntington S, Scott EP. Platelet utilization in a university hospital. JAMA 1988;259: 2414-8.
22. Lawrence JB, Yomtovian R, Hammons T, Masarik S, Lazarus HM. Lowering the prophylactic platelet transfusion (ProPltTx) trigger: a prospective analysis. Transfusion 1994;34:Suppl:53S. abstract.
23. Wandt H, Frank M, Schneider C, Ehninger G, Link H. The 10,000/ μL trigger compared to 20,000/μL for prophylactic platelet transfusion in AML: a prospective comparative multicenter study. Blood 1996;88:Suppl 1:443a. abstract.
24. Gil-Fernández JJ, Alegre A, Fernández-Villalta MJ, et al. Clinical results of a stringent policy on prophylactic platelet transfusion: non-randomized comparative analysis in 190 bone marrow transplant patients from a single institution. Bone Marrow Transplant 1996;18:931-5.
25. Bishop JF, Matthews JP, McGarth K, Yuen K, Wolf MM, Szer J. Factors influencing 20-hour increments after platelet transfusion. Transfusion 1991;31:392-6.
26. Hanson SR, Slichter SJ. Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement. Blood 1985;66:1105-9.
27. Murphy WG. Prophylactic platelet transfusion in acute leukaemia. Lancet 1992;339:120.
28. Hänsler E, Fehr J, Keller H. Estimation of the lower limits of manual and automated platelet counting. Am J Clin Pathol 1996;105:782-7.