Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis

Multiple Sclerosis

Volumn 16, Issue 7, 2010, Pages 883-887

  Castellazzi, Massimiliano ^a   Tamborino, Carmine ^a   Cani, Alice ^a   Negri, Elena ^a   Baldi, Eleonora ^a   Seraceni, Silva ^b   Tola, Maria Rosaria ^a   Granieri, Enrico ^a   Contini, Carlo ^b   Fainardi, Enrico ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY HOSPITAL OF FERRARA   (Italy)

Author keywords

cerebrospinal fluid; Epstein Barr virus; intrathecal synthesis; multiple sclerosis

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN 1; IMMUNOGLOBULIN G; VIRUS CAPSID ANTIGEN; CAPSID PROTEIN; EPSTEIN-BARR VIRAL CAPSID ANTIGEN; VIRUS ANTIBODY; VIRUS ANTIGEN;

ADULT; ANTIBODY RESPONSE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; BLOOD; CASE CONTROL STUDY; DISABILITY; EPSTEIN BARR VIRUS; HUMORAL IMMUNITY; IMMUNOLOGY; ITALY; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; VIROLOGY;

ADULT; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CAPSID PROTEINS; CASE-CONTROL STUDIES; DISABILITY EVALUATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNITY, HUMORAL; ITALY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; SEVERITY OF ILLNESS INDEX;

EID: 77955020345     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458510368051     Document Type: Article

References (15)

1. Ascherio A., Munger KL Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann Neurol 2007 ; 61: 288-299. (Pubitemid 46676728)
2. Serafini B., Rosicarelli B., Franciotta D., et al. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med 2007 ; 204: 2899-2912.
3. Opsahl ML, Kennedy PGE. An attempt to investigate the presence of Epstein Barr virus in multiple sclerosis and normal control brain tissue. J Neurol 2007 ; 254: 425-430.
4. Willis SN, Stadelmann C., Rodig SJ, et al. Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009 ; 132: 3318-3328.
5. Peferoen LAN, Lamers F., Lodder LNR, et al. Epstein- Barr virus infection is not a characteristic feature in the central nervous system in established multiple sclerosis. Brain 2009 16 Nov; (Advance Access) DOI: 10.1093/ brain/awp296.
6. Farrell RA, Antony D., Wall GR, et al. Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 2009 ; 73: 32-38.
7. Zivadinov R., Zorzon M., Wienstock-Guttmann B., et al. Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis. J Neurol Neurosurg Psychiatry 2009 ; 80: 620-625.
8. Lönemann JD, Tintoró M., Messmer B., et al. Elevated EBNA1 immune responses predict conversion to multiple sclerosis. Ann Neurol 2009 13 Oct; (accepted article) DOI: 10.1002/ana. 21886.
9. Cepok S., Zhou D., Srivastava R., et al. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest 2005 ; 115: 1352-1360.
10. Rand KH, Houck H., Denslow ND, Heilman KM Epstein-Barr virus nuclear antigen-1 (EBNA-1) associated oligoclonal bands in patients with multiple sclerosis. J Neuroimmunol 2000 ; 173: 32-39.
11. Pohl D., Rostasy K., Jacobi C., et al. Intrathecal antibody production against Epstein-Barr and other neurotropic viruses in pediatric and adult onset multiple sclerosis. J Neurol 2009 28 Aug; (Epub ahead of print) DOI 10.10007/s00415-009-5296-y.
12. McDonald WI, Compston A., Edan G., et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 2001 ; 50: 121-127.
13. Salden HJM, Bas BM, Hermas JT, Janson PC Analytical performance of the three commercially available nephelometers compared quantifying protein in serum and cerebrospinal fluid. Clin Chem 1988 ; 34: 1594-1596.
14. Franciotta D., Avolio C., Capello E., Lolli F., participating members AINI. Consensus recommendations of the Italian Association for Neuroimmunology for immunochemical cerebrospinal fluid examination. J Neurol Sci 2005 ; 237: 5-11.
15. Reiber H., Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem 1991 ; 37: 1153-1160.