An attempt to investigate the presence of Epstein Barr virus in multiple sclerosis and normal control brain tissue

Journal of Neurology

Volumn 254, Issue 4, 2007, Pages 425-430

  Opsahl, Margaret L ^a   Kennedy, Peter G E ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

EBV; mRNA (F)ISH; Multiple sclerosis

Indexed keywords

MESSENGER RNA;

ARTICLE; AUTOPSY; BRAIN TISSUE; CONTROLLED STUDY; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; HEALTH CARE FACILITY; HUMAN; HUMAN TISSUE; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RNA ANALYSIS; SAMPLE; VIRUS DETECTION; VIRUS GENE;

AGED; AGED, 80 AND OVER; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VIRAL PROTEINS;

EID: 34249088905     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-006-0316-7     Document Type: Article

References (32)

1. Alliel PM, F. A. U., Perin JP, Pierig, R, Rieger F (1998) An endogenous retrovirus with nucleic acid sequences similar to those of the multiple sclerosis associated retrovirus at the human T-cell receptor alpha, delta gene locus.- Cell Mol Biol 44(6):927-931
2. Alotaibi S, Kennedy J, Tellier R, Stephens D, Banwell B (2004) Epstein- Barr virus in pediatric multiple sclerosis. JAMA 291:1875-1879
3. Alvarez-Lafuente R, De las Heras V, Bartolome M, Picazo JJ, Arroyo R (2004) Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection. Arch Neurol 61:1523-1527
4. Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernan MA, Olek MJ, Hankinson SE, Hunter DJ (2001) Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA 286:3083-3088
5. Berti R, Brennan MB, Soldan SS, Ohayon JM, Casareto L, McFarland HF, Jacobson S (2002) Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression. J Neurovirol 8(3):250-6250-256
6. Bloom DC (2004) HSV LAT and neuronal survival. Int Rev Immunol 23:187-198
7. Blumberg BM, Mock DJ, Powers JM, Ito M, Assouline JG, Baker JV, Chen B, Goodman AD, (2000) The HHV6 paradox: ubiquitous commensal or insidious pathogen? A two-step in situ PCR approach. J Clin Virol 16(3):159-178
8. Bray PF, Bloomer LC, Salmon VC, Bagley MH, Larsen PD (1983) Epstein-Barr virus infection and antibody synthesis in patients with multiple sclerosis. Arch Neurol 40:406-408
9. Bray PF, Culp KW, McFarlin DE, Panitch HS, Torkelson RD, Schlight JP (1992) Demyelinating disease after neurologically complicated primary Epstein-Barr virus infection. Neurology 42:278-282
10. Bray PF, Luka J, Bray PF, Culp KW, Schlight JP, (1992) Antibodies against Epstein-Barr nuclear antigen (EBNA) in multiple sclerosis CSF, and two pentapeptide sequence identities between EBNA and myelin basic protein. Neurology 42:1798-1804
11. Buljevac D, van Doornum GJ, Flach HZ, Groen J, Osterhaus AD, Hop W, van Doorn PA, van der Meche FG, Hintzen RQ (2005) Epstein-Barr virus and disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 76:1377-1381
12. Cepok S, Zhou D, Srivastava R, Nessler S, Stei S, Bussow K, Sommer N, Hemmer B (2005) Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest 115:1352-1360
13. Challoner PB, Smith KT, Parker JD, MacLeod DL, Coulter SN, Rose TM, Schultz ER, Bennett JL, Garber RL, Chang M (1995) Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci U S A 92(16):7440-7444
14. Chapenko S, Millers A, Nora Z, Logina I, Kukaine R, Murovska M (2003) Correlation between HHV-6 reactivation and multiple sclerosis disease activity. J Med Virol 69:111-117
15. Cohrs RJ, Gilden DH, Mahalingam R (2004) Varicella zoster virus latency, neurological disease and experimental models: an update. Front Biosci 9:751-762
16. Ferrante P, Omodeo-Zorini E, Zuffolato MR, Mancuso R, Caldarelli-Stefano R, Puricelli S, Mediati M, Losciale L, Caputo D (1997) Human T-cell lymphotropic virus tax and Epstein-Barr virus DNA in peripheral blood of multiple sclerosis patients during acute attack. Acta Neurol Scand Suppl 169:79-85
17. Friedman JE, Lyons MJ, Cu G. FAU, Ablashl DV, Whitman JE, Edgar M, Koskiniemi M, Vaheri A, Zabriskie JB (1999) The association of the human herpesvirus-6 and MS. Mult Scler 5(5):355-362
18. Goodman AD, Mock DJ, Powers JM, Baker JV, Blumberg BM (2003) Human herpesvirus 6 genome and antigen in acute multiple sclerosis lesions. J InfectDis 187:1365-1376
19. Haahr S, Plesner AM, Vestergaard BF, Hollsberg P, (2004) A role of late Epstein-Barr virus infection in multiple sclerosis. Acta Neurol Scand 109:270-275
20. Herndon RM (1996) Herpesviruses in multiple sclerosis. Arch Neurol 53(2):123-124
21. Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L (2002) A functional and structural basis for TCR crossreactivity in multiple sclerosis. Nat Immunol 3:940-943
22. Larsen PD, Bloomer LC, Bray PF (1985) Epstein-Barr nuclear antigen and viral capsid antigen antibody titers in multiple sclerosis. Neurology 35:435-438
23. Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A (2005) Temporal relationship between elevation of epstein-barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA 293:2496-2500
24. Opsahl ML, Kennedy PG (2005) Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter. Brain 128:516-527
25. Opsahl ML, Kennedy PG (2006) Investigating the presence of human herpesvirus 7 and 8 in multiple sclerosis and normal control brain tissue. J Neurol Sci 240:37-44
26. Perry VH, Newman TA, Cunningham C (2003) The impact of systemic infection on the progression of neurodegenerative disease. Nat Rev Neurosci 4:103-112
27. Stuve O, Racke M, Hemmer B (2004) Viral pathogens in multiple sclerosis: an intriguing (hi)story. Arch Neuro l61:1500-1502
28. Su JM, Perlaky L, Li XN, Leung HC, Antalffy B, Armstrong D, Lau CC (2004) Comparison of ethanol versus formalin fixation on preservation of histology and RNA in laser capture microdissected brain tissues. Brain Pathol 14:175-182
29. Tienari PJ, Wikstrom J, Sajantila A, Palo J, Peltonen L (1992) Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene. Lancet 340:987-991
30. Villoslada P, Juste C, Tintore M, Llorenc V, Codina G, Pozo-Rosich P, Montalban X (2003) The immune response against herpesvirus is more prominent in the early stages of MS. Neurology 60:1944-1948
31. Wagner HJ, Hennig H, Jabs WJ, Siekhaus A, Wessel K, Wandinger KP (2000) Altered prevalence and reactivity of anti-Epstein-Barr virus antibodies in patients with multiple sclerosis. Viral Immunol 13:497-502
32. Wagner HJ, Munger KL, Ascherio A (2004) Plasma viral load of Epstein- Barr virus and risk of multiple sclerosis. Eur J Neurol 11:833-834