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Volumn 11, Issue 8, 2010, Pages 901-910

Optimal antiretroviral therapy: HIV-1 treatment strategies to avoid and overcome drug resistance

Author keywords

Anti HIV agent; antiretroviral therapy; CCR5 antagonist; drug resistance; integrase inhibitor

Indexed keywords

1349572; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ATAZANAVIR PLUS RITONAVIR; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; EFAVIRENZ; ELVITEGRAVIR; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ENFUVIRTIDE; ETRAVIRINE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INTEGRASE INHIBITOR; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR PLUS RITONAVIR; MARAVIROC; MYELOABLATIVE AGENT; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RALTEGRAVIR; RILPIVIRINE; RITONAVIR; RITONAVIR PLUS TIPRANAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; VICRIVIROC; VIRUS DNA; ZIDOVUDINE;

EID: 77954983245     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (8)

References (65)
  • 1
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD: HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science (1996) 271(5255):1582-1586.
    • (1996) Science , vol.271 , Issue.5255 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 2
    • 0024267430 scopus 로고
    • Fidelity of HIV-1 reverse transcriptase
    • Preston BD, Poiesz BJ, Loeb LA: Fidelity of HIV-1 reverse transcriptase. Science (1988) 242(4882):1168-1171.
    • (1988) Science , vol.242 , Issue.4882 , pp. 1168-1171
    • Preston, B.D.1    Poiesz, B.J.2    Loeb, L.A.3
  • 9
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder BA, Kemp SD: Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science (1989) 246(4934):1155-1158.
    • (1989) Science , vol.246 , Issue.4934 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 10
    • 60449087073 scopus 로고    scopus 로고
    • Nine-year trends in clinically relevant reduced susceptibility of HIV-1 to antiretrovirals
    • Sista P, Rinehart A, Wasikowski B, Winters B, Pattery T, Bacheler L: Nine-year trends in clinically relevant reduced susceptibility of HIV-1 to antiretrovirals. J Clin Virol (2009) 44(3):190-194.
    • (2009) J Clin Virol , vol.44 , Issue.3 , pp. 190-194
    • Sista, P.1    Rinehart, A.2    Wasikowski, B.3    Winters, B.4    Pattery, T.5    Bacheler, L.6
  • 13
    • 0031753527 scopus 로고    scopus 로고
    • Ramey RR 2nd, Kuritzkes DR: Resistance mutations in protease and reverse transcriptase genes of human immunodeficiency virus type 1 isolates from patients with combination antiretroviral therapy failure
    • Young B, Johnson S, Bahktiari M, Shugarts D, Young RK, Allen M, Ramey RR 2nd, Kuritzkes DR: Resistance mutations in protease and reverse transcriptase genes of human immunodeficiency virus type 1 isolates from patients with combination antiretroviral therapy failure. J Infect Dis (1998) 178(5): 1497-1501.
    • (1998) J Infect Dis , vol.178 , Issue.5 , pp. 1497-1501
    • Young, B.1    Johnson, S.2    Bahktiari, M.3    Shugarts, D.4    Young, R.K.5    Allen, M.6
  • 22
    • 34247628907 scopus 로고    scopus 로고
    • UK Register of HIV Seroconverters: Evidence of a decline in transmitted HIV-1 drug resistance in the United Kingdom
    • UK Collaborative Group on HIV Drug Resistance, UK Collaborative HIV Cohort Study
    • UK Collaborative Group on HIV Drug Resistance, UK Collaborative HIV Cohort Study, UK Register of HIV Seroconverters: Evidence of a decline in transmitted HIV-1 drug resistance in the United Kingdom. AIDS (2007) 21(8):1035-1039.
    • (2007) AIDS , vol.21 , Issue.8 , pp. 1035-1039
  • 28
    • 67650694310 scopus 로고    scopus 로고
    • A4001029 Study Group: A double-blind, placebo-controlled trial of maraviroc in treatment-experienced patients infected with non-R5 HIV-1
    • Saag M, Goodrich J, Fätkenheuer G, Clotet B, Clumeck N, Sullivan J, Westby M, van der Ryst E, Mayer H, A4001029 Study Group: A double-blind, placebo-controlled trial of maraviroc in treatment-experienced patients infected with non-R5 HIV-1. J Infect Dis (2009) 199(11):1638-1647
    • (2009) J Infect Dis , vol.199 , Issue.11 , pp. 1638-1647
    • Saag, M.1    Goodrich, J.2    Fätkenheuer, G.3    Clotet, B.4    Clumeck, N.5    Sullivan, J.6    Westby, M.7    Van Der Ryst, E.8    Mayer, H.9
  • 29
    • 77749271329 scopus 로고    scopus 로고
    • Maraviroc versus efavirenz, both in combination with zidovudine- lamivudine, for the treatment of antiretroviralnave subjects with CCR5-tropic HIV-1 infection
    • Cooper DA, Heera J, Goodrich J, Tawadrous M, Saag M, Dejesus E, Clumeck N, Walmsley S, Ting N, Coakley E, Reeves JD et al: Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviralnave subjects with CCR5-tropic HIV-1 infection. J Infect Dis (2010) 201(6):803-813.
    • (2010) J Infect Dis , vol.201 , Issue.6 , pp. 803-813
    • Cooper, D.A.1    Heera, J.2    Goodrich, J.3    Tawadrous, M.4    Saag, M.5    Dejesus, E.6    Clumeck, N.7    Walmsley, S.8    Ting, N.9    Coakley, E.10    Reeves, J.D.11
  • 30
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4- using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby M, Lewis M, Whitcomb J, Youle M, Pozniak AL, James IT, Jenkins TM, Perros M, van der Ryst E: Emergence of CXCR4- using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol (2006) 80(10):4909-4920.
    • (2006) J Virol , vol.80 , Issue.10 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3    Youle, M.4    Pozniak, A.L.5    James, I.T.6    Jenkins, T.M.7    Perros, M.8    Van Der Ryst, E.9
  • 31
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitorbound receptor for entry
    • Westby M, Smith-Burchnell C, Mori J, Lewis M, Mosley M, Stockdale M, Dorr P, Ciaramella G, Perros M: Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitorbound receptor for entry. J Virol (2007) 81(5):2359-2371.
    • (2007) J Virol , vol.81 , Issue.5 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3    Lewis, M.4    Mosley, M.5    Stockdale, M.6    Dorr, P.7    Ciaramella, G.8    Perros, M.9
  • 32
    • 65249151382 scopus 로고    scopus 로고
    • Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41
    • Anastassopoulou CG, Ketas TJ, Klasse PJ, Moore JP: Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41. Proc Natl Acad Sci USA (2009) 106(13):5318-5323.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.13 , pp. 5318-5323
    • Anastassopoulou, C.G.1    Ketas, T.J.2    Klasse, P.J.3    Moore, J.P.4
  • 35
    • 72849119170 scopus 로고    scopus 로고
    • High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrugresistant HIV: Results of the ANRS 139 TRIO trial
    • Yazdanpanah Y, Fagard C, Descamps D, Taburet AM, Colin C, Roquebert B, Katlama C, Pialoux G, Jacomet C, Piketty C, Bollens D et al: High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrugresistant HIV: Results of the ANRS 139 TRIO trial. Clin Infect Dis (2009) 49(9):1441-1449.
    • (2009) Clin Infect Dis , vol.49 , Issue.9 , pp. 1441-1449
    • Yazdanpanah, Y.1    Fagard, C.2    Descamps, D.3    Taburet, A.M.4    Colin, C.5    Roquebert, B.6    Katlama, C.7    Pialoux, G.8    Jacomet, C.9    Piketty, C.10    Bollens, D.11
  • 36
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-nave patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial
    • Lennox JL, DeJesus E, Lazzarin A, Pollard RB, Madruga JV, Berger DS, Zhao J, Xu X, Williams-Diaz A, Rodgers AJ, Barnard RJ et al: Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-nave patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial. Lancet (2009) 374(9692):796-806.
    • (2009) Lancet , vol.374 , Issue.9692 , pp. 796-806
    • Lennox, J.L.1    Dejesus, E.2    Lazzarin, A.3    Pollard, R.B.4    Madruga, J.V.5    Berger, D.S.6    Zhao, J.7    Xu, X.8    Williams-Diaz, A.9    Rodgers, A.J.10    Barnard, R.J.11
  • 38
    • 77749267991 scopus 로고    scopus 로고
    • Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV type 1: Results of a phase 2, randomized, controlled, dose-ranging clinical trial
    • Zolopa AR, Berger DS, Lampiris H, Zhong L, Chuck SL, Enejosa JV, Kearney BP, Cheng AK: Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV type 1: Results of a phase 2, randomized, controlled, dose-ranging clinical trial. J Infect Dis (2010) 201(6):814-822.
    • (2010) J Infect Dis , vol.201 , Issue.6 , pp. 814-822
    • Zolopa, A.R.1    Berger, D.S.2    Lampiris, H.3    Zhong, L.4    Chuck, S.L.5    Enejosa, J.V.6    Kearney, B.P.7    Cheng, A.K.8
  • 39
    • 77954989605 scopus 로고    scopus 로고
    • Single-tablet, fixed-dose regimen of elvitegravir/emtricitabine/tenofovir disoproxil fumarate/GS-9350 achieves a high rate of virologic suppression and GS-9350 is an effective booster
    • San Francisco, CA, USA Abs 58LB
    • Cohen C, Shamblaw D, Ruane P, Elion R, DeJesus E, Liu H, Zhong L, Warren D, Kearney B, Chuck S: Single-tablet, fixed-dose regimen of elvitegravir/ emtricitabine/tenofovir disoproxil fumarate/GS-9350 achieves a high rate of virologic suppression and GS-9350 is an effective booster. Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, USA (2010) 17:Abs 58LB.
    • (2010) Conference on Retroviruses and Opportunistic Infections , pp. 17
    • Cohen, C.1    Shamblaw, D.2    Ruane, P.3    Elion, R.4    Dejesus, E.5    Liu, H.6    Zhong, L.7    Warren, D.8    Kearney, B.9    Chuck, S.10
  • 40
    • 75149175071 scopus 로고    scopus 로고
    • Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): Two multicentre, double-blind, randomised controlled trials
    • Eron JJ, Young B, Cooper DA, Youle M, Dejesus E, Andrade- Villanueva J, Workman C, Zajdenverg R, Fätkenheuer G, Berger DS, Kumar PN et al: Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir- based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): Two multicentre, double-blind, randomised controlled trials. Lancet (2010) 375(9712):396-407.
    • (2010) Lancet , vol.375 , Issue.9712 , pp. 396-407
    • Eron, J.J.1    Young, B.2    Cooper, D.A.3    Youle, M.4    Dejesus, E.5    Andrade-Villanueva, J.6    Workman, C.7    Zajdenverg, R.8    Fätkenheuer, G.9    Berger, D.S.10    Kumar, P.N.11
  • 42
    • 33746576313 scopus 로고    scopus 로고
    • Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials
    • Hicks CB, Cahn P, Cooper DA, Walmsley SL, Katlama C, Clotet B, Lazzarin A, Johnson MA, Neubacher D, Mayers D, Valdez H et al: Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials. Lancet (2006) 368(9534): 466-475.
    • (2006) Lancet , vol.368 , Issue.9534 , pp. 466-475
    • Hicks, C.B.1    Cahn, P.2    Cooper, D.A.3    Walmsley, S.L.4    Katlama, C.5    Clotet, B.6    Lazzarin, A.7    Johnson, M.A.8    Neubacher, D.9    Mayers, D.10    Valdez, H.11
  • 43
    • 34347329093 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial
    • Madruga JV, Berger D, McMurchie M, Suter F, Banhegyi D, Ruxrungtham K, Norris D, Lefebvre E, de Béthune MP, Tomaka F, De Pauw M et al: Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial. Lancet (2007) 370(9581):49-58.
    • (2007) Lancet , vol.370 , Issue.9581 , pp. 49-58
    • Madruga, J.V.1    Berger, D.2    McMurchie, M.3    Suter, F.4    Banhegyi, D.5    Ruxrungtham, K.6    Norris, D.7    Lefebvre, E.8    De Béthune, M.P.9    Tomaka, F.10    De Pauw, M.11
  • 44
    • 34047207229 scopus 로고    scopus 로고
    • Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
    • Clotet B, Bellos N, Molina JM, Cooper D, Goffard JC, Lazzarin A, Wöhrmann A, Katlama C, Wilkin T, Haubrich R, Cohen C et al: Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials. Lancet (2007) 369(9568): 1169-1178.
    • (2007) Lancet , vol.369 , Issue.9568 , pp. 1169-1178
    • Clotet, B.1    Bellos, N.2    Molina, J.M.3    Cooper, D.4    Goffard, J.C.5    Lazzarin, A.6    Wöhrmann, A.7    Katlama, C.8    Wilkin, T.9    Haubrich, R.10    Cohen, C.11
  • 46
    • 34247869104 scopus 로고    scopus 로고
    • Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials
    • Hill A, Moyle G: Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials. HIV Med (2007) 8(4):259-264.
    • (2007) HIV Med , vol.8 , Issue.4 , pp. 259-264
    • Hill, A.1    Moyle, G.2
  • 47
    • 77952659138 scopus 로고    scopus 로고
    • Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: An independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors
    • Talbot A, Grant P, Taylor J, Baril JG, Liu TF, Charest H, Brenner B, Roger M, Shafer R, Cantin R, Zolopa A: Predicting tipranavir and darunavir resistance using genotypic, phenotypic, and virtual phenotypic resistance patterns: An independent cohort analysis of clinical isolates highly resistant to all other protease inhibitors. Antimicrob Agents Chemother (2010) 54(6):2473-2479.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.6 , pp. 2473-2479
    • Talbot, A.1    Grant, P.2    Taylor, J.3    Baril, J.G.4    Liu, T.F.5    Charest, H.6    Brenner, B.7    Roger, M.8    Shafer, R.9    Cantin, R.10    Zolopa, A.11
  • 48
    • 56749184934 scopus 로고    scopus 로고
    • Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ ritonavir: Review of cases from the FDA's Adverse Event Reporting System
    • Chan-Tack KM, Struble KA, Birnkrant DB: Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ ritonavir: Review of cases from the FDA's Adverse Event Reporting System. AIDS Patient Care STDS (2008) 22(11): 843-850.
    • (2008) AIDS Patient Care STDS , vol.22 , Issue.11 , pp. 843-850
    • Chan-Tack, K.M.1    Struble, K.A.2    Birnkrant, D.B.3
  • 58
    • 0034069732 scopus 로고    scopus 로고
    • The role of abacavir (ABC, 1592) in antiretroviral therapy-experienced patients: Results from a randomized, double-blind, trial
    • CNA3002 European Study Team
    • Katlama C, Clotet B, Plettenberg A, Jost J, Arasteh K, Bernasconi E, Jeantils V, Cutrell A, Stone C, Ait-Khaled M, Purdon S: The role of abacavir (ABC, 1592) in antiretroviral therapy-experienced patients: Results from a randomized, double-blind, trial. CNA3002 European Study Team. AIDS (2000) 14(7):781-789.
    • (2000) AIDS , vol.14 , Issue.7 , pp. 781-789
    • Katlama, C.1    Clotet, B.2    Plettenberg, A.3    Jost, J.4    Arasteh, K.5    Bernasconi, E.6    Jeantils, V.7    Cutrell, A.8    Stone, C.9    Ait-Khaled, M.10    Purdon, S.11
  • 60
    • 27144549662 scopus 로고    scopus 로고
    • Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection
    • Deeks SG, Hoh R, Neilands TB, Liegler T, Aweeka F, Petropoulos CJ, Grant RM, Martin JN: Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection. J Infect Dis (2005) 192(9):1537-1544.
    • (2005) J Infect Dis , vol.192 , Issue.9 , pp. 1537-1544
    • Deeks, S.G.1    Hoh, R.2    Neilands, T.B.3    Liegler, T.4    Aweeka, F.5    Petropoulos, C.J.6    Grant, R.M.7    Martin, J.N.8
  • 61
    • 46349112103 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel
    • Recommendations of an International AIDS Society-USA panel 2008
    • Hirsch MS, Günthard HF, Schapiro JM, Brun-Vézinet F, Clotet B, Hammer SM, Johnson VA, Kuritzkes DR, Mellors JW, Pillay D, Yeni PG et al: Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Clin Infect Dis (2008) 47(2):266-285.
    • (2008) Clin Infect Dis , vol.47 , Issue.2 , pp. 266-285
    • Hirsch Ms, G.1
  • 64
    • 77951284541 scopus 로고    scopus 로고
    • Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women
    • Sturt AS, Dokubo EK, Sint TT: Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women. Cochrane Database Syst Rev (2010) (3):CD008440.
    • (2010) Cochrane Database Syst Rev , vol.3
    • Sturt, A.S.1    Dokubo, E.K.2    Sint, T.T.3
  • 65
    • 77952573336 scopus 로고    scopus 로고
    • Optimal monitoring strategies for guiding when to switch first-line antiretroviral therapy regimens for treatment failure in adults and adolescents living with HIV in low-resource settings
    • Chang LW, Harris J, Humphreys E: Optimal monitoring strategies for guiding when to switch first-line antiretroviral therapy regimens for treatment failure in adults and adolescents living with HIV in low-resource settings. Cochrane Database Syst Rev (2010) (4):CD008494.
    • (2010) Cochrane Database Syst Rev , vol.4
    • Chang, L.W.1    Harris, J.2    Humphreys, E.3


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