Intravenous infusion of n-3 polyunsaturated fatty acids and inducibility of ventricular tachycardia in patients with implantable cardioverter defibrillator

Europace

Volumn 12, Issue 7, 2010, Pages 941-946

  Madsen, Trine ^a   Christensen, Jeppe Hagstrup ^a   Thøgersen, Anna Margrethe ^a   Schmidt, Erik Berg ^a   Toft, Egon ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

Author keywords

Electrophysiological study; Fish oil; Implantable cardioverter defibrillator; Inducibility; n 3 Polyunsaturated fatty acids; Ventricular tachycardia

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; PLACEBO; CARDIOTONIC AGENT; OMEGA 3 FATTY ACID;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEFIBRILLATOR; DOUBLE BLIND PROCEDURE; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE TACHYCARDIA; HUMAN; ISCHEMIC HEART DISEASE; LIPID COMPOSITION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; INTRAVENOUS DRUG ADMINISTRATION; PLACEBO EFFECT; TACHYCARDIA, VENTRICULAR; TREATMENT OUTCOME;

CARDIOTONIC AGENTS; CROSS-OVER STUDIES; DEFIBRILLATORS, IMPLANTABLE; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; PLACEBO EFFECT; TACHYCARDIA, VENTRICULAR; TREATMENT OUTCOME;

EID: 77954968566     PISSN: 10995129     EISSN: 15322092     Source Type: Journal    
DOI: 10.1093/europace/euq085     Document Type: Article

References (18)

1. Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. N Engl J Med 2001;345:1473-1482
2. Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M et al. ACC/ AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J 2006;27:2099-2140
3. Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J et al. Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA 1995;274:1363-1367
4. Albert CM, Campos H, Stampfer MJ, Ridker PM, Manson JE, Willett WC et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med 2002;346:1113-1118
5. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999;354:447-455
6. Schrepf R, Limmert T, Claus WP, Theisen K, Sellmayer A. Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia. Lancet 2004;363:1441-1442
7. Metcalf RG, Sanders P, James MJ, Cleland LG, Young GD. Effect of dietary n-3 polyunsaturated fatty acids on the inducibility of ventricular tachycardia in patients with ischemic cardiomyopathy. Am J Cardiol 2008;101:758-761
8. Christensen JH, Riahi S, Schmidt EB, Molgaard H, Kirstein PA, Heath F et al. n-3 Fatty acids and ventricular arrhythmias in patients with ischaemic heart disease and implantable cardioverter defibrillators. Europace 2005;7:338-344 (Pubitemid 40790418)
9. Raitt MH, Connor WE, Morris C, Kron J, Halperin B, Chugh SS et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293:2884-2891
10. Leaf A, Albert CM, Josephson M, Steinhaus D, Kluger J, Kang JX et al. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation 2005;112:2762-2768 (Pubitemid 41641669)
11. Brouwer IA, Zock PL, Camm AJ, Bocker D, Hauer RN, Wever EF et al. Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. JAMA 2006;295:2613-2619
12. Jenkins DJ, Josse AR, Beyene J, Dorian P, Burr ML, LaBelle R et al. Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis. CMAJ 2008;178:157-164
13. Carpentier YA, Hacquebard M. Intravenous lipid emulsions to deliver omega 3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 2006;75:145-148
14. Elmadfa I, Stroh S, Brandt K, Schlotzer E. Influence of a single parenteral application of a 10% fish oil emulsion on plasma fatty acid pattern and the function of thrombocytes in young adult men. Ann Nutr Metab 1993;37:8-13.
15. Portois L, Deckelbaum RJ, Malaisse WJ, Carpentier YA. Accumulation rapide d'eicosapentaénoate dans les phospholipids cellularies après injection intraveineuse d'une émulsion d'huile de poisson et de triglycérides à châne moyenne à des sujets normaux. Nutr Clin Metabol 2004;18:S53.
16. Weylandt KH, Kang JX, Leaf A. Polyunsaturated fatty acids exert antiarrhythmic actions as free acids rather than in phospholipids. Lipids 1996;31:977-982
17. Nair SS, Leitch J, Falconer J, Garg ML. Cardiac (n-3) non-esterified fatty acids are selectively increased in fish oil-fed pigs following myocardial ischemia. J Nutr 1999; 129:1518-1523
18. Billman GE, Kang JX, Leaf A. Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. Circulation 1999;99:2452-2457