Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells

Toxicon

Volumn 56, Issue 4, 2010, Pages 508-520

  Chien, Ching Ming ^a   Chang, Shang Yu ^a   Lin, Kuei Li ^a   Chiu, Chien Chih ^a   Chang, Long Sen ^b   Lin, Shinne Ren ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; COBROTOXIN; COBROTOXIN III; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN KINASE B; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SQUAMOUS CELL CARCINOMA;

NAJA ATRA;

EID: 77954957743     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.05.007     Document Type: Article

References (44)

1. Adams J.M., Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998, 281:1322-1326.
2. Ang K.K., Berkey B.A., Tu X., Zhang H.Z., Katz R., Hammond E.H., Fu K.K., Milas L. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res. 2002, 62:7350-7356.
3. Antonsson B., Martinou J.C. The Bcl-2 protein family. Exp. Cell Res. 2000, 256:50-57.
4. Arteaga C.L. Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin. Oncol 2002, 29:S3-S9.
5. Benati D., Baldari C.T. Src family kinases as potential therapeutic targets for malignancies and immunological disorders. Curr. Med. Chem. 2008, 15:1154-1165.
6. Biscardi J.S., Maa M.C., Tice D.A., Cox M.E., Leu T.H., Parsons S.J. c-Src mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J. Biol. Chem. 1999, 274:8335-8343.
7. Biscardi J.S., Ishizawar R.C., Silva C.M., Parsons S.J. Tyrosine kinase signaling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res. 2000, 2:203-210.
8. Chen K.C., Chiou Y.L., Kao P.H., Lin S.R., Chang L.S. Taiwan cobra cardiotoxins induce apoptotic death of human neuroblastoma SK-N-SH cells mediated by reactive oxygen species generation and mitochondrial depolarization. Toxicon 2008, 51:624-634.
9. Chen X., Lv P., Liu J., Xu K. Apoptosis of human hepatocellular carcinoma cell (HepG2) induced by cardiotoxin III through S-phase arrest. Exp. Toxicol. Pathol 2009, 61:307-315.
10. Chien C.M., Yang S.H., Lu M.C., Chang L.S., Lin S.R. Cardiotoxin III induces apoptosis in T24 cells via reactive oxygen species-independent mitochondrial death pathway. Drug Develop. Res. 2004, 63:219-224.
11. Chien C.M., Yang S.H., Chang L.S., Lin S.R. Involvement of both endoplasmic reticulum- and mitochondria-dependent pathway in cardiotoxin III-induced apoptosis in HL-60 cells. Clin. Exp. Pharm. Physiol 2008, 35:1059-1064.
12. Chien C.M., Lin K.L., Su J.C., Chang L.S., Lin S.R. Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin from Naja naja atra. J. Nat. Prod. 2009, 72:1735-1740.
13. Chiu C.C., Lin K.L., Chien C.M., Chang L.S., lin S.R. Effects of cardiotoxin III on NFκB function, proliferation and apoptosis in human breast MCF-7 cancer cells. Oncol. Res. 2009, 17:311-321.
14. Datta S.R., Brunet A., Greenberg M.E. Cellular survival: a play in three Akts. Gene Dev. 1999, 13:2905-2927.
15. Deveraux Q.L., Reed J.C. IAP family proteins: suppressors of apoptosis. Gene Dev. 1999, 13:239-252.
16. Dufton M.J., Hider R.C. The structure and pharmacology of Elapid cytotoxins. Snake Toxins 1991, 259-302. Pergamon Press, New York. A.L. Harvey (Ed.).
17. Forastiere A.A., Koch W., Trotti A., Sidransky D. Head and neck cancer. N. Engl. J. Med. 2002, 345:1890-1900.
18. Frame M.C. Src in cancer: deregulation and consequences for cell behaviour. Biochem. Biophys. Acta 2002, 1602:114-130.
19. Gross A., McDonnell J.M., Korsmeyer S.J. Bcl-2 family members and the mitochondria in apoptosis. Gene Dev. 1999, 13:1899-1991.
20. Hauck C.R., Hsia D.A., Puente X.S., Cheresh D.A., Schlaepfer D.D. FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J. 2002, 21:6289-6302.
21. Jefferies S., Foulkes W.D. Genetic mechanisms in squamous cell carcinoma. Oral Oncol. 2001, 37:115-126.
22. Jia H.Y., Wu J.X., Zhu X.F., Chen J.M., Yang S.P., Yan H.J., Tan L., Zeng Y.X., Huang W. ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells. Leukemia Res. 2009, 33:1512-1519.
23. 2 with cardiotoxin-like activities from Bungarus fasciatus venom. Toxicon 1989, 27:247-257.
24. Johnson F.M., Sagal B., Talpaz M., Donato N.J. Dasatinib (BMS-354825) tyrosine kinase inhibitor suppressed invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin. Cancer Res. 2005, 11:6924-6932.
25. Kotha A., Sekharam M., Cilenti L., Siddiquee K., Khaled A., Zervos A.S., Carter B., Turkson J., Jove R. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated protein. Mol. Cancer Ther. 2006, 5:621-629.
26. Kuo P.L., Ni E.C., Tsai E.M., Hsu Y.L. Dehydrocostuslactone disrupts signal transducers ans activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells. Mol. Cancer Ther. 2009, 8:1328-1339.
27. Kurebayashi J., Okubo S., Yamamoto Y., Ikeda M., Tanaka K., Otsuki T., Sonoo H. Additive anti-tumor effects of gefitinib and imatinib on anaplastic thyroid cancer cells. Cancer Chemother. Pharmacol. 2006, 58:460-470.
28. Lin S.R., Chang L.S., Chang K.L. Separation and structure-function studies of Taiwan cobra cardiotoxins. J. Protein Chem. 2002, 21:81-86.
29. Lin K.L., Su J.C., Chien C.M., Chuang P.W., Chang L.S., Lin S.R. Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells. Toxicon 2010, 55:1263-1273.
30. Lu Y., Yu Q., Liu J.H., Zhang J., Wang H., Koul D., McMurray J.S., Fang X., Yung W.K.A., Siminovitch K.A., Mills G.B. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/Akt cascades. J. Biol. Chem. 2003, 278:40057-40066.
31. Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
32. Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J. Clin. Oncol 2002, 20:S1-S13.
33. Nautiyal J., Majumder P., Patel B.B., Lee F.Y., Majumdar A.P.N. Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling. Cancer Lett. 2009, 283:143-151.
34. Niu G., Bowman T., Huang M., Shivers S., Reintgen D., Daud A., Chang A., Kraker A., Jove R., Yu H. Roles of activated and Stat3 signaling in melanoma tumor cell growth. Oncogene 2002, 21:7001-7010.
35. Park E.J., Min H.Y., Chung H.J., Hong J.Y., Kang Y.J., Hung T.M., Youn U.J., Kim Y.S., Bae K., Kang S.S., Lee S.K. Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett. 2009, 277:133-140.
36. Parsons J.T., Parsons S.J. Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. Curr. Opin. Cell Biol. 1997, 9:187-192.
37. Sato K., Nagao T., Iwasaki T., Nishihira Y., Fukami Y. Src-dependent phosphorylation of the EGF redeptor Tyr-845 mediates Stat-p21 Waf1 pathway in A431 cells. Genes Cells 2003, 8:95-103.
38. Stevens-Truss R., Messer W.S., Hinman C.L. Heart and T-lymphocyte cell surfaces both exhibit positive cooperativity in binding a membrane-lytic toxin. J. Membrane Biol. 1996, 150:113-122.
39. + T lymphocytes. Toxicol. Appl. Pharm. 2003, 193:97-105.
40. Tsai C.H., Yang S.H., Chien C.M., Lu M.C., Lo C.S., Lin Y.H., Hu X.W., Lin S.R. Mechanism of cardiotoxin III-induced apoptosis in human colorectal cancer Colo205 cells. Clin. Exp.Pharm. Physiol. 2006, 33:177-182.
41. Tsao A.S., He D., Saigal B., Liu S., Lee J.J., Bakkannagari S., Ordonez N.G., Hong W.K., Wistuba I., Johnson F.M. Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion. Mol. Cancer Ther. 2007, 6:1962-1972.
42. Xi S., Zhang Q., Dyer K.F., Lerner E.C., Smithgall T.E., Gooding W.E., Kamens J., Grandis J.R. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J. Biol. Chem. 2003, 278:31574-31583.
43. Yang S.H., Chien C.M., Chang L.S., Lin S.R. Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells. Toxicon 2007, 49:966-974.
44. Yip K.W., Reed J.C. Bcl-2 family proteins and cancer. Oncogene 2008, 27:6398-6406.