Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells

Toxicon

Volumn 55, Issue 7, 2010, Pages 1263-1273

  Lin, Kuei Li ^a   Su, Jung Chen ^a   Chien, Ching Ming ^a   Chuang, Pei Wen ^a,b   Chang, Long Sen ^c   Lin, Shinne Ren ^a,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b Kaohsiung Municipal Min Sheng Hospital   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Akt; Cardiotoxin; Cobra venom; JAK2; MDA MB 231 cells; PI3K; STAT3

Indexed keywords

CARDIOTOXIN; CARDIOTOXIN 3; CASPASE 3; CASPASE 9; CYTOCHROME C; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLSERINE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE B; SNAKE VENOM; STAT3 PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; WORTMANNIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SNAKE; TAIWAN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; COBRA CARDIOTOXIN PROTEINS; COBRA VENOMS; CYTOCHROMES C; CYTOSOL; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; GENES, BCL-2; HUMANS; JANUS KINASE 2; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TAIWAN;

NAJA ATRA;

EID: 77951652643     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2010.01.017     Document Type: Article

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