Chemotherapeutic agents targeting the tubulin cytoskeleton modify lps-induced cytokine secretion by dendritic cells and increase antigen presentation

Journal of Immunotherapy

Volumn 33, Issue 4, 2010, Pages 364-370

  Marin Esteban, Viviana ^a,b   Charron, Dominique ^a   Gelin, Catherine ^a   Mooney, Nuala ^a  

^a UNIVERSITÉ PARIS DIDEROT   (France)

^b INSERM   (France)

Author keywords

Antigen presentation; Dendritic cell; Tubulin cytoskeleton

Indexed keywords

ANTIINFECTIVE AGENT; COLCHICINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PACLITAXEL; TUBULIN; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSKELETON; DENDRITIC CELL; DOWN REGULATION; DRUG ACTIVITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MICROTUBULE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 77954953909     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181cd1094     Document Type: Article

References (26)

1. Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature. 2007;449:419-426.
2. Geiger B, Rosen D, Berke G. Spatial relationships of microtubule- organizing centers and the contact area of cytotoxic T lymphocytes and target cells. J Cell Biol. 1982;95:137-143.
3. Kupfer A, Dennert G, Singer SJ. Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. Proc Natl Acad Sci U S A. 1983;80:7224-7228.
4. Martin-Cofreces NB, Robles-Valero J, Cabrero JR, et al. MTOC translocation modulates IS formation and controls sustained T cell signaling. J Cell Biol. 2008;182:951-962.
5. Al-Alwan MM, Rowden G, Lee TD, et al. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J Immunol. 2001;166:1452-1456.
6. Delaguillaumie A, Marin-Esteban V, Setterblad N, et al. Contrasting cytoskeletal regulation of MHC class II peptide presentation by human B cells or dendritic cells. Eur J Immunol. 2008;38:1096-1105.
7. Kaneno R, Shurin GV, Tourkova IL, et al. Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations. J Transl Med. 2009;7:58.
8. Shurin GV, Tourkova IL, Kaneno R, et al. Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism. J Immunol. 2009;183:137-144.
9. Mizumoto N, Tanaka H, Matsushima H, et al. Colchicine promotes antigen cross-presentation by murine dendritic cells. J Invest Dermatol. 2007;127:1543-1546.
10. Manthey CL, Vogel SN. Interactions of lipopolysaccharide with macrophages. Immunol Ser. 1994;60:63-81.
11. Marin-Esteban V, Abdul M, Charron D, et al. Dendritic cells differentiated in the presence of a single-stranded viral RNA sequence conserve their ability to activate CD4 T lymphocytes but lose their capacity for Th1 polarization. Clin Vaccine Immunol. 2008;15:954-962.
12. Setterblad N, Becart S, Charron D, et al. B cell lipid rafts regulate both peptide-dependent and peptide-independent APC-T cell interaction. J Immunol. 2004;173:1876-1886.
13. Billadeau DD, Nolz JC, Gomez TS. Regulation of T-cell activation by the cytoskeleton. Nat Rev Immunol. 2007;7:131-143.
14. Ben-Chetrit E, Levy M. Colchicine: 1998 update. Semin Arthritis Rheum. 1998;28:48-59.
15. Kubik NJ III, Katz JD. Familial Mediterranean fever. Am J Orthop. 2000;29:553-555.
16. Yurdakul S, Mat C, Tuzun Y, et al. A double-blind trial of colchicine in Behcet's syndrome. Arthritis Rheum. 2001;44:2686-2692.
17. Entzian P, Schlaak M, Seitzer U, et al. Antiinflammatory and antifibrotic properties of colchicine: implications for idiopathic pulmonary fibrosis. Lung. 1997;175:41-51.
18. Ferrua B, Manie S, Doglio A, et al. Stimulation of human interleukin 1 production and specific mRNA expression by microtubule-disrupting drugs. Cell Immunol. 1990;131:391-397.
19. Zimmer SM, Liu J, Clayton JL, et al. Paclitaxel binding to human and murine MD-2. J Biol Chem. 2008;283:27916-27926.
20. Kawasaki K, Akashi S, Shimazu R, et al. Mouse toll-like receptor 4. MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem. 2000;275:2251-2254.
21. Carta S, Tassi S, Semino C, et al. Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood. 2006;108:1618-1626.
22. Hoffmann A, Levchenko A, Scott ML, et al. The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science. 2002;298:1241-1245.
23. Arrighi JF, Rebsamen M, Rousset F, et al. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J Immunol. 2001;166:3837-3845.
24. Mizumoto N, Hui F, Edelbaum D, et al. Differential activation profiles of multiple transcription factors during dendritic cell maturation. J Invest Dermatol. 2005;124:718-724.
25. Peachman KK, Rao M, Palmer DR, et al. Functional microtubules are required for antigen processing by macrophages and dendritic cells. Immunol Lett. 2004;95:13-24.
26. Bloom O, Unternaehrer JJ, Jiang A, et al. Spinophilin participates in information transfer at immunological synapses. J Cell Biol. 2008;181:203-211.