Dose dependency of the pharmacokinetics and acute lipolytic actions of growth hormone

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 10, 2002, Pages 4691-4698

  Hansen, Troels Krarup ^a   Gravholt, Claus Højbjerg ^b   Rskov, Hans ^a   Rasmussen, Michael Højby ^a   Christiansen, Jens Sandahl ^b   Jørgensen, Jens Otto L ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE BINDING PROTEIN; HUMAN GROWTH HORMONE; LIPID;

ADIPOSE TISSUE; ADULT; AGE; AREA UNDER THE CURVE; ARTICLE; BODY COMPOSITION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOSE RESPONSE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; GENDER; HORMONE SENSITIVITY; HUMAN; HUMAN EXPERIMENT; IMPEDANCE; LIPOLYSIS; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ADIPOSE TISSUE; ADULT; BODY COMPOSITION; CARRIER PROTEINS; ELECTRIC IMPEDANCE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIPIDS; LIPOLYSIS; MALE; METABOLIC CLEARANCE RATE; MICRODIALYSIS; MIDDLE AGED; PLACEBOS; REGRESSION ANALYSIS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0036775478     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020563     Document Type: Article

References (45)

1. Hansen TK, Jorgensen JO, Christiansen JS 2002 Body composition and circulating levels of insulin, insulin-like growth factor-binding protein-1 and growth hormone (GH)-binding protein affect the pharmacokinetics of GH in adults independently of age. J Clin Endocrinol Metab 87:2185-2193
2. Baumann G, Amburn KD, Buchanan TA 1987 The effect of circulating growth hormone-binding protein on metabolic clearance, distribution, and degradation of human growth hormone. J Clin Endocrinol Metab 64:657-660
3. Dubey AK, Hanukoglu A, Hansen BC, Kowarski AA 1988 Metabolic clearance rates of synthetic human growth hormone in lean and obese male rhesus monkeys. J Clin Endocrinol Metab 67:1064-1067
4. Veldhuis JD, Iranmanesh A, Ho KK, Waters MJ, Johnson ML, Lizarralde G 1991 Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 72:51-59
5. Sohmiya M, Kato Y 1992 Renal clearance, metabolic clearance rate, and half-life of human growth hormone in young and aged subjects. J Clin Endocrinol Metab 75:1487-1490
6. Veldhuis JD, Johnson ML, Faunt LM, Mercado M, Baumann G 1993 Influence of the high-affinity growth hormone (GH)-binding protein on plasma profiles of free and bound GH and on the apparent half-life of GH. Modeling analysis and clinical applications. J Clin Invest 91:629-641
7. Haffner D, Schaefer F, Girard J, Ritz E, Mehls O 1994 Metabolic clearance of recombinant human growth hormone in health and chronic renal failure. J Clin Invest 93:1163-1171
8. Schaefer F, Baumann G, Haffner D, Faunt LM, Johnson ML, Mercado M, Ritz E, Mehls O, Veldhuis JD 1996 Multifactorial control of the elimination kinetics of unbound (free) growth hormone (GH) in the human: Regulation by age, adiposity, renal function, and steady state concentrations of GH in plasma. J Clin Endocrinol Metab 81:22-31
9. Vahl N, Moller N, Lauritzen T, Christiansen JS, Jorgensen JO 1997 Metabolic effects and pharmacokinetics of a growth hormone pulse in healthy adults: Relation to age, sex, and body composition. J Clin Endocrinol Metab 82:3612-3618
10. Le Roith D, Bondy C, Yakar S, Liu JL, Butler A 2001 The somatomedin hypothesis: 2001. Endocr Rev 22:53-74
11. Husman B, Gustafsson JA, Andersson G 1988 Receptor-mediated endocytosis and degradation of bovine growth hormone in rat liver. Mol Cell Endocrinol 59:13-25
12. Bullier-Picard F, Postel-Vinay MC, Kayser C 1989 In vivo uptake of human growth hormone in male rat liver. J Endocrinol 121:19-25
13. Raben M, Hollenberg C 1959 Effect of growth hormone on plasma fatty acids. J Clin Invest 38:484-488
14. Moller N, Jorgensen JO, Alberti KG, Flyvbjerg A, Schmitz O 1990 Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 70:1179-1186
15. Cersosimo E, Danou F, Persson M, Miles JM 1996 Effects of pulsatile delivery of basal growth hormone on lipolysis in humans. Am J Physiol 271:E123-E126
16. Gravholt CH, Schmitz O, Simonsen L, Bulow J, Christiansen JS, Moller N 1999 Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. Am J Physiol 277:E848-E854
17. Moller N, Schmitz O, Porksen N, Moller J, Jorgensen JO 1992 Dose-response studies on the metabolic effects of a growth hormone pulse in humans. Metabolism 41:172-175
18. Moberg E, Hagstrom-Toft E, Amer P, Bolinder J 1997 Protracted glucose fall in subcutaneous adipose tissue and skeletal muscle compared with blood during insulin-induced hypoglycaemia. Diabetologia 40:1320-1326
19. Fisker S, Ebdrup L, Orskov H 1998 Influence of growth hormone binding protein on growth hormone estimation in different immunoassays. Scand J Clin Lab Invest 58:373-381
20. Frystyk J, Dinesen B, Orskov H 1995 Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II. Growth Regul 5:169-176
21. Lloyd B, Burrin J, Smythe P, Alberti KG 1978 Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem 24:1724-1729
22. Fisker S, Frystyk J, Skriver L, Vestbo E, Ho KK, Orskov H 1996 A simple, rapid immunometric assay for determination of functional and growth hormone-occupied growth hormone-binding protein in human serum. Eur J Clin Invest 26:779-785
23. Deurenberg P, Tagliabue A, Schouten FJ 1995 Multi-frequency impedance for the prediction of extracellular water and total body water. Br J Nutr 73:349-358
24. Lam TK, Leung DT 1988 More on simplified calculation of body-surface area. N Engl J Med 318:1130
25. Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI 1987 Growth hormone receptor and serum binding protein: Purification, cloning and expression. Nature 330:537-543
26. Sotiropoulos A, Goujon L, Simonin G, Kelly PA, Postel VM, Finidori J 1993 Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor. Endocrinology 132:1863-1865
27. Harrison SM, Barnard R, Ho KY, Rajkovic I, Waters MJ 1995 Control of growth hormone (GH) binding protein release from human hepatoma cells expressing full-length GH receptor. Endocrinology 136:651-659
28. Tonshoff B, Cronin MJ, Reichert M, Haffner D, Wingen AM, Blum WF, Mehls O 1997 Reduced concentration of serum growth hormone (GH)-binding protein in children with chronic renal failure: Correlation with GH insensitivity. The European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. The German Study Group for Growth Hormone Treatment in Chronic Renal Failure. J Clin Endocrinol Metab 82:1007-1013
29. Baumann G 2001 Growth hormone binding protein 2001. J Pediatr Endocrinol Metab 14:355-375
30. Baumann G, Amburn K, Shaw MA 1988 The circulating growth hormone (GH)-binding protein complex: A major constituent of plasma GH in man. Endocrinology 122:976-984
31. Leung KC, Doyle N, Ballesteros M, Waters MJ, Ho KK 2000 Insulin regulation of human hepatic growth hormone receptors: Divergent effects on biosynthesis and surface translocation. J Clin Endocrinol Metab 85:4712-4720
32. Frystyk J, Skjaerbaek C, Vestbo E, Fisker S, Orskov H 1999 Circulating levels of free insulin-like growth factors in obese subjects: The impact of type 2 diabetes. Diabetes Metab Res Rev 15:314-322
33. Mercado M, Molitch ME, Baumann G 1992 Low plasma growth hormone binding protein in IDDM. Diabetes 41:605-609
34. Brismar K, Femqvist-Forbes E, Wahren J, Hall K 1994 Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. J Clin Endocrinol Metab 79:872-878
35. Amiel SA, Sherwin RS, Hintz RL, Gertner JM, Press CM, Tamborlane WV 1984 Effect of diabetes and its control on insulin-like growth factors in the young subject with type I diabetes. Diabetes 33:1175-1179
36. Hanaire-Broutin H, Sallerin-Caute B, Poncet MF, Tauber M, Bastide R, Chale JJ, Rosenfeld R, Tauber JP 1996 Effect of intraperitoneal insulin delivery on growth hormone binding protein, insulin-like growth factor (IGF)-I, and IGF-binding protein-3 in IDDM. Diabetologia 39:1498-1504
37. Iranmanesh A, Lizarralde G, Veldhuis JD 1991 Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 73:1081-1088
38. Fisker S, Vahl N, Jorgensen JO, Christiansen JS, Orskov H 1997 Abdominal fat determines growth hormone-binding protein levels in healthy nonobese adults. J Clin Endocrinol Metab 82:123-128
39. Roelen CA, Koppeschaar HP, de-Vries WR, Snel YE, Doerga ME, Zelissen PM, Thijssen JH, Blankenstein MA 1997 Visceral adipose tissue is associated with circulating high affinity growth hormone-binding protein. J Clin Endocrinol Metab 82:760-764
40. Rasmussen MH, Ho KK, Kjems L, Hilsted J 1996 Serum growth hormone-binding protein in obesity: Effect of a short-term, very low calorie diet and diet-induced weight loss. J Clin Endocrinol Metab 81:1519-1524
41. Moller N, Jorgensen JO, Moller J, Orskov L, Ovesen P, Schmitz O, Christiansen JS, Orskov H 1995 Metabolic effects of growth hormone in humans. Metabolism 44:33-36
42. Butler P, Kryshak E, Rizza R 1991 Mechanism of growth hormone-induced postprandial carbohydrate intolerance in humans. Am J Physiol 260:E513-E520
43. Hartman ML, Faria AC, Vance ML, Johnson ML, Thorner MO, Veldhuis JD 1991 Temporal structure of in vivo growth hormone secretory events in humans. Am J Physiol 260:E101-E110
44. Goodman HM 1970 Permissive effects of hormones on lipolysis. Endocrinology 86:1064-1074
45. Marcus C, Bolme P, Micha-Johansson G, Margery V, Bronnegard M 1994 Growth hormone increases the lipolytic sensitivity for catecholamines in adipocytes from healthy adults. Life Sci 54:1335-1341