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Volumn 2, Issue 1, 2008, Pages 51-58

Slips, leaks and channels in glutamate transporters

Author keywords

Aspartate; Chloride channel; Glutamate; Leak; Slip; Transporter

Indexed keywords

ARCHAEAL PROTEIN; ASPARTIC ACID; CHLORIDE CHANNEL; EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATE TRANSPORTER; GLUTAMATE TRANSPORTER HOMOLOG FROM PYROCOCCUS HORIKOSHII; POTASSIUM ION; PROTON; SODIUM ION; UNCLASSIFIED DRUG; COTRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2;

EID: 55749090236     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.2.1.6047     Document Type: Review
Times cited : (31)

References (46)
  • 1
    • 0019203675 scopus 로고
    • Kinetic properties of ion carriers and channels
    • Lauger P. Kinetic properties of ion carriers and channels. J Membr Biol 1980; 57:163-178
    • (1980) J Membr Biol , vol.57 , pp. 163-178
    • Lauger, P.1
  • 2
    • 0029860263 scopus 로고    scopus 로고
    • Flux coupling in a neuronal glutamate transporter
    • DOI 10.1038/383634a0
    • Zerangue N, Kavanaugh MP. Flux coupling in a neuronal glutamate transporter. Nature 1996; 383:634-637 (Pubitemid 26347587)
    • (1996) Nature , vol.383 , Issue.6601 , pp. 634-637
    • Zerangue, N.1    Kavanaugh, M.P.2
  • 3
    • 0029076899 scopus 로고
    • An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
    • Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 1995; 375:599-603.
    • (1995) Nature , vol.375 , pp. 599-603
    • Fairman, W.A.1    Vandenberg, R.J.2    Arriza, J.L.3    Kavanaugh, M.P.4    Amara, S.G.5
  • 4
    • 0029142729 scopus 로고
    • Ion fluxes associated with excitatory amino acid transport
    • Wadiche JI, Amara SG, Kavanaugh MP. Ion fluxes associated with excitatory amino acid transport. Neuron 1995; 15:721-728
    • (1995) Neuron , vol.15 , pp. 721-728
    • Wadiche, J.I.1    Amara, S.G.2    Kavanaugh, M.P.3
  • 5
    • 0031036030 scopus 로고    scopus 로고
    • Multiple ionic conductances of the human dopamine transporter: The actions of dopamine and psychostimulants
    • Sonders MS, Zhu SJ, Zahniser NR, Kavanaugh MP, Amara SG. Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J Neurosci 1997; 17:960-974
    • (1997) J Neurosci , vol.17 , pp. 960-974
    • Sonders, M.S.1    Zhu, S.J.2    Zahniser, N.R.3    Kavanaugh, M.P.4    Amara, S.G.5
  • 7
    • 0023521289 scopus 로고
    • Anion and cation permeability of a chloride channel in rat hippocampal neurons
    • DOI 10.1085/jgp.90.4.453
    • Franciolini F, Nonner W. Anion and cation permeability of a chloride channel in rat hippocampal neurons. J Gen Physiol 1987; 90:453-478 (Pubitemid 18008318)
    • (1987) Journal of General Physiology , vol.90 , Issue.4 , pp. 453-478
    • Franciolini, F.1    Nonner, W.2
  • 8
    • 1542288949 scopus 로고    scopus 로고
    • - channels
    • DOI 10.1038/nature02314
    • Accardi A, Miller C. Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Nature 2004; 427:803-807 (Pubitemid 38297735)
    • (2004) Nature , vol.427 , Issue.6977 , pp. 803-807
    • Accardi, A.1    Miller, C.2
  • 10
    • 34848821581 scopus 로고    scopus 로고
    • Extracellular glutamate concentration in hippocampul slice
    • Herman MAa, Jahr CE. Extracellular glutamate concentration in hippocampul slice. J Neurosci 2007; 27:9736-9741
    • (2007) J Neurosci , vol.27 , pp. 9736-9741
    • Herman, M.Aa.1    Jahr, C.E.2
  • 11
    • 7244254186 scopus 로고    scopus 로고
    • Structure of a glutamate transporter homologue from Pyrococcus horikoshii
    • DOI 10.1038/nature03018
    • Yernool D, Boudker O, Jin Y, Gouaux E. Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature 2004; 431:811-818 (Pubitemid 39434071)
    • (2004) Nature , vol.431 , Issue.7010 , pp. 811-818
    • Yernool, D.1    Boudker, O.2    Jin, Y.3    Gouaux, E.4
  • 13
    • 0242424106 scopus 로고    scopus 로고
    • Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus
    • Yernool D, Boudker O, Folta-Stogniew E, Gouaux E. Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus. Biochem 2003; 42:12981-12988
    • (2003) Biochem , vol.42 , pp. 12981-12988
    • Yernool, D.1    Boudker, O.2    Folta-Stogniew, E.3    Gouaux, E.4
  • 14
    • 33846505059 scopus 로고    scopus 로고
    • Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
    • DOI 10.1038/nature05455, PII NATURE05455
    • Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter. Nature 2007; 445:387-393 (Pubitemid 46160902)
    • (2007) Nature , vol.445 , Issue.7126 , pp. 387-393
    • Boudker, O.1    Ryan, R.M.2    Yernool, D.3    Shimamoto, K.4    Gouaux, E.5
  • 15
    • 0034529012 scopus 로고    scopus 로고
    • Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter
    • DOI 10.1074/jbc.M006536200
    • Bendahan A, Armon A, Madani N, Kavanaugh MP, Kanner BI. Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter. J Biol Chem 2000; 275:37436-37442 (Pubitemid 32004848)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.48 , pp. 37436-37442
    • Bendahan, A.1    Armon, A.2    Madani, N.3    Kavanaugh, M.P.4    Kanner, B.I.5
  • 16
    • 0032434691 scopus 로고    scopus 로고
    • A reentrant loop domain in the glutamate carrier EAAT1 participates in substrate binding and translocation
    • Seal RP, Amara SG. A reentrant loop domain in the glutamate carrier EAAT1 participates in substrate binding and translocation. Neuron 1998; 21:1487-1498
    • (1998) Neuron , vol.21 , pp. 1487-1498
    • Seal, R.P.1    Amara, S.G.2
  • 17
    • 0029023101 scopus 로고
    • Constitutive ion fluxes and substrate binding domains of human glutamate transporters
    • Vandenberg RJ, Arriza JL, Amara SG, Kavanaugh MP. Constitutive ion fluxes and substrate binding domains of human glutamate transporters. J Biol Chem 1995; 270:17668-17671
    • (1995) J Biol Chem , vol.270 , pp. 17668-17671
    • Vandenberg, R.J.1    Arriza, J.L.2    Amara, S.G.3    Kavanaugh, M.P.4
  • 18
    • 0032511029 scopus 로고    scopus 로고
    • Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2
    • Mitrovic AD, Amara SG, Johnston GA, Vandenberg RJ. Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J Biol Chem 1998; 273:14698-14706
    • (1998) J Biol Chem , vol.273 , pp. 14698-14706
    • Mitrovic, A.D.1    Amara, S.G.2    Johnston, G.A.3    Vandenberg, R.J.4
  • 19
    • 33947308773 scopus 로고    scopus 로고
    • The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits
    • Leary GP, Stone EF, Holley DC, Kavanaugh MP. The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits. J Neurosci 2007; 27:2938-2942
    • (2007) J Neurosci , vol.27 , pp. 2938-2942
    • Leary, G.P.1    Stone, E.F.2    Holley, D.C.3    Kavanaugh, M.P.4
  • 20
    • 33947318986 scopus 로고    scopus 로고
    • The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits
    • Koch HP, Brown RL, Larsson HP. The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits. J Neurosci 2007; 27:2943-2947
    • (2007) J Neurosci , vol.27 , pp. 2943-2947
    • Koch, H.P.1    Brown, R.L.2    Larsson, H.P.3
  • 21
    • 2442693929 scopus 로고    scopus 로고
    • The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway
    • Ryan RM, Mitrovic AD, Vandenberg RJ. The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway. J Biol Chem 2004; 279:20742-20751
    • (2004) J Biol Chem , vol.279 , pp. 20742-20751
    • Ryan, R.M.1    Mitrovic, A.D.2    Vandenberg, R.J.3
  • 22
    • 33744518437 scopus 로고    scopus 로고
    • + to the glutamate free form and cycling of the glutamate transporter EAAC1
    • 10.1074/jbc.M510739200.
    • + to the glutamate free form and cycling of the glutamate transporter EAAC1. J Biol Chem 2006; 10.1074/jbc.M510739200.
    • (2006) J Biol Chem
    • Tao, Z.1    Zhang, Z.2    Grewer, C.3
  • 23
    • 33947726549 scopus 로고    scopus 로고
    • + binding to the glutamate transporter EAAC1
    • + binding to the glutamate transporter EAAC1. J Gen Physiol 2007; 129:331-344
    • (2007) J Gen Physiol , vol.129 , pp. 331-344
    • Tao, Z.1    Grewer, C.2
  • 25
    • 0023856913 scopus 로고
    • A presynaptic action of glutamate at the cone output synapse
    • DOI 10.1038/332451a0
    • Sarantis M, Everett K, Attwell D. A presynaptic action of glutamate at the cone output synapse. Nature 1988; 332:451-453 (Pubitemid 18090247)
    • (1988) Nature , vol.332 , Issue.6163 , pp. 451-453
    • Sarantis, M.1    Everett, K.2    Attwell, D.3
  • 26
    • 0028786382 scopus 로고
    • Glutamate-gated chloride channel with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander
    • Picaud SA, Larsson HP, Grant GB, Lecar H, Werblin FS. Glutamate-gated chloride channel with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander. J Neurophysiol 1995; 74:1760-1771
    • (1995) J Neurophysiol , vol.74 , pp. 1760-1771
    • Picaud, S.A.1    Larsson, H.P.2    Grant, G.B.3    Lecar, H.4    Werblin, F.S.5
  • 27
    • 0029025867 scopus 로고
    • A glutamate-activated chloride current in cone-driven on bipolar cells of the white perch retina
    • Grant GB, Dowling JE. A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina. J Neurosci 1995; 15:3852-3862
    • (1995) J Neurosci , vol.15 , pp. 3852-3862
    • Grant, G.B.1    Dowling, J.E.2
  • 29
    • 0032189020 scopus 로고    scopus 로고
    • Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel
    • Wadiche JI, Kavanaugh MP. Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J Neurosci 1998; 18:7650-7661
    • (1998) J Neurosci , vol.18 , pp. 7650-7661
    • Wadiche, J.I.1    Kavanaugh, M.P.2
  • 32
    • 34247648737 scopus 로고    scopus 로고
    • The uncoupled chloride conductance of a bacterial glutamate transporter homolog
    • Ryan RM, Mindell JA. The uncoupled chloride conductance of a bacterial glutamate transporter homolog. Nat Struct Mol Biol 2007; 14:365-371
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 365-371
    • Ryan, R.M.1    Mindell, J.A.2
  • 33
    • 0346118920 scopus 로고    scopus 로고
    • Glutamate Modifies Ion Conduction and Voltage-dependent Gating of Excitatory Amino Acid Transporter-associated Anion Channels
    • DOI 10.1074/jbc.M307990200
    • Melzer N, Biela A, Fahlke C. Glutamate modifies ion conduction and voltage-dependent gating of excitatory amino acid transporter-associated anion channels. J Biol Chem 2003; 278:50112-50119 (Pubitemid 37548848)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.50 , pp. 50112-50119
    • Melzer, N.1    Biela, A.2    Fahlke, C.3
  • 34
    • 34548286807 scopus 로고    scopus 로고
    • Mutations in transmembrane domains 5 and 7 of the human excitatory amino acid transporter 1 affect the substrate-activated anion channel
    • DOI 10.1021/bi700647f
    • Huang S, Vandenberg RJ. Mutations in transmembrane domains 5 and 7 of the human excitatory amino acid transporter 1 affect the substrate-activated anion channel. Biochemistry 2007; 46:9685-9692 (Pubitemid 47328574)
    • (2007) Biochemistry , vol.46 , Issue.34 , pp. 9685-9692
    • Huang, S.1    Vandenberg, R.J.2
  • 35
    • 33644664236 scopus 로고    scopus 로고
    • Arachidonic acid elicits a substrategated proton current associated with the glutamate transporter EAAT4
    • Fairman WA, Sonders MS, Murdoch GH, Amara SG. Arachidonic acid elicits a substrate- gated proton current associated with the glutamate transporter EAAT4. Nature Neuroscience 1998; 1:105-113 (Pubitemid 128652656)
    • (1998) Nature Neuroscience , vol.1 , Issue.2 , pp. 105-113
    • Fairman, W.A.1    Sonders, M.S.2    Murdoch, G.H.3    Amara, S.G.4
  • 36
    • 0032504238 scopus 로고    scopus 로고
    • Arachidonic acid activates a proton current in the rat glutamate transporter EAAT4
    • Tzingounis AV, Lin CL, Rothstein JD, Kavanaugh MP. Arachidonic acid activates a proton current in the rat glutamate transporter EAAT4. J Biol Chem 1998; 273:17315-17317
    • (1998) J Biol Chem , vol.273 , pp. 17315-17317
    • Tzingounis, A.V.1    Lin, C.L.2    Rothstein, J.D.3    Kavanaugh, M.P.4
  • 37
    • 0035395177 scopus 로고    scopus 로고
    • Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4
    • Lond
    • Poulsen MV, Vandenberg RJ. Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4. J Physiol (Lond) 2001; 534:159-167
    • (2001) J Physiol , vol.534 , pp. 159-167
    • Poulsen, M.V.1    Vandenberg, R.J.2
  • 38
    • 0028911077 scopus 로고
    • Differential modulation of human glutamate transporter subtypes by arachidonic acid
    • Zerangue N, Arriza JL, Amara SG, Kavanaugh MP. Differential modulation of human glutamate transporter subtypes by arachidonic acid. J Biol Chem 1995; 270:6433-6435
    • (1995) J Biol Chem , vol.270 , pp. 6433-6435
    • Zerangue, N.1    Arriza, J.L.2    Amara, S.G.3    Kavanaugh, M.P.4
  • 39
    • 0029114107 scopus 로고
    • Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry
    • Chaudhry FA, Lehre KP, van Lookeren Campagne M, Ottersen OP, Danbolt NC, Storm- Mathisen J. Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron 1995; 15:711-720
    • (1995) Neuron , vol.15 , pp. 711-720
    • Chaudhry, F.A.1    Lehre, K.P.2    Van Lookeren Campagne, M.3    Ottersen, O.P.4    Danbolt, N.C.5    Storm- Mathisen, J.6
  • 40
    • 0032531028 scopus 로고    scopus 로고
    • Anion currents and predicted glutamate flux through a neuronal glutamate transporter
    • Otis TS, Jahr CE. Anion currents and predicted glutamate flux through a neuronal glutamate transporter. J Neurosci 1998; 18:7099-7110
    • (1998) J Neurosci , vol.18 , pp. 7099-7110
    • Otis, T.S.1    Jahr, C.E.2
  • 41
    • 33750470835 scopus 로고    scopus 로고
    • Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling
    • DOI 10.1038/nn1793, PII NN1793
    • Veruki ML, Morkve SH, Hartveit E. Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling. Nat Neurosci 2006; 9:1388-1396 (Pubitemid 44646211)
    • (2006) Nature Neuroscience , vol.9 , Issue.11 , pp. 1388-1396
    • Veruki, M.L.1    Morkve, S.H.2    Hartveit, E.3
  • 42
    • 0036784803 scopus 로고    scopus 로고
    • Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons
    • Ingram SL, Prasad BM, Amara SG. Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neurons. Nat Neurosci 2002; 5:971-978
    • (2002) Nat Neurosci , vol.5 , pp. 971-978
    • Ingram, S.L.1    Prasad, B.M.2    Amara, S.G.3
  • 44
    • 0037134466 scopus 로고    scopus 로고
    • Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1
    • Ryan RM, Vandenberg RJ. Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1. J Biol Chem 2002; 277:13494-13500
    • (2002) J Biol Chem , vol.277 , pp. 13494-13500
    • Ryan, R.M.1    Vandenberg, R.J.2
  • 45
    • 0037134479 scopus 로고    scopus 로고
    • Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter
    • DOI 10.1074/jbc.M110861200
    • Borre L, Kavanaugh MP, Kanner BI. Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter. J Biol Chem 2002; 277:13501-13507 (Pubitemid 34967947)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.16 , pp. 13501-13507
    • Borre, L.1    Kavanaugh, M.P.2    Kanner, B.I.3


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