Sulfhydryl modification of cysteine mutants of a neuronal glutamate transporter reveals an inverse relationship between sodium dependent conformational changes and the glutamate-gated anion conductance

Neuropharmacology

Volumn 49, Issue 6, 2005, Pages 862-871

  Shachnai, Liat ^a   Shimamoto, Keiko ^b   Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

Anion conductance; Coupled flux; Glutamate transporters; Mutants; Sulfhydryl modification

Indexed keywords

ANION; CHLORIDE; CYSTEINE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; MUTANT PROTEIN; SODIUM; SULFONIC ACID DERIVATIVE; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE CONDUCTANCE; CHEMICAL MODIFICATION; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; ION CONDUCTANCE; ISOTOPE LABELING; MEMBRANE CURRENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; WILD TYPE;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASPARTIC ACID; CELL LINE; CLONING, MOLECULAR; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; GLUTAMATES; HUMANS; ION CHANNEL GATING; LITHIUM; MEMBRANE POTENTIALS; MESYLATES; MICROINJECTIONS; MUTAGENESIS; MUTATION; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SODIUM; SULFHYDRYL COMPOUNDS; TRANSFECTION; XENOPUS;

EID: 26944479295     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.07.005     Document Type: Article

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