-
1
-
-
22144491932
-
Symptomatic narcolepsy, cataplexy, and hypersomnia, and their implications in the hypothalamic hypocretin/ orexin system
-
Nishino S, Kanbayashi T: Symptomatic narcolepsy, cataplexy, and hypersomnia, and their implications in the hypothalamic hypocretin/ orexin system. Sleep Med Rev 2005, 9:269-310.
-
(2005)
Sleep Med Rev
, vol.9
, pp. 269-310
-
-
Nishino, S.1
Kanbayashi, T.2
-
2
-
-
34248149838
-
Clinical and neurobiological aspects of narcolepsy
-
The author examines the centrality of hypocretin neurotransmission impairment to the pathophysiologic mechanism in narcolepsy and the potential of ligand replacement as a relevant therapeutic option in view of the results of recent animal studies
-
• Nishino S: Clinical and neurobiological aspects of narcolepsy. Sleep Med 2007, 8:373-399. The author examines the centrality of hypocretin neurotransmission impairment to the pathophysiologic mechanism in narcolepsy and the potential of ligand replacement as a relevant therapeutic option in view of the results of recent animal studies.
-
(2007)
Sleep Med
, vol.8
, pp. 373-399
-
-
Nishino, S.1
-
3
-
-
0036791834
-
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
-
Mignot E, Lammers GJ, Ripley B, et al.: The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002, 59:1553-1562.
-
(2002)
Arch Neurol
, vol.59
, pp. 1553-1562
-
-
Mignot, E.1
Lammers, G.J.2
Ripley, B.3
-
4
-
-
0038785552
-
The hypocretin/orexin system in health and disease
-
Nishino S: The hypocretin/orexin system in health and disease. Bio Psychiatry 2003, 54:87-95.
-
(2003)
Bio Psychiatry
, vol.54
, pp. 87-95
-
-
Nishino, S.1
-
5
-
-
0030955520
-
Pharmacological aspects of human and canine narcolepsy
-
Nishino S, Mignot E: Pharmacological aspects of human and canine narcolepsy. Prog Neurobiol 1997, 52:27-78.
-
(1997)
Prog Neurobiol
, vol.52
, pp. 27-78
-
-
Nishino, S.1
Mignot, E.2
-
6
-
-
33846322228
-
The neurobiology of sleep in relation to mental illness
-
Edited by Charney DS, Nestler EJ. New York: Oxford University Press
-
Nishino S, Taheri S, Black J, et al.: The neurobiology of sleep in relation to mental illness. In Neurobiology of Mental Illness. Edited by Charney DS, Nestler EJ. New York: Oxford University Press; 2004:1160-1179.
-
(2004)
Neurobiology of Mental Illness
, pp. 1160-1179
-
-
Nishino, S.1
Taheri, S.2
Black, J.3
-
7
-
-
3042621975
-
Sleep neurobiology for the clinician
-
Espana RA, Scammell TE: Sleep neurobiology for the clinician. Sleep 2004, 27:811-820.
-
(2004)
Sleep
, vol.27
, pp. 811-820
-
-
Espana, R.A.1
Scammell, T.E.2
-
8
-
-
0030867241
-
Value of the multiple sleep latency test (MSLT) for diagnosis of narcolepsy
-
Aldrich MS, Chervin RD, Marlow BA: Value of the multiple sleep latency test (MSLT) for diagnosis of narcolepsy. Sleep 1997, 20:620-629.
-
(1997)
Sleep
, vol.20
, pp. 620-629
-
-
Aldrich, M.S.1
Chervin, R.D.2
Marlow, B.A.3
-
9
-
-
0026635816
-
Isolated sleep paralysis elicited by sleep interruption
-
Takeuchi T, Miyasist A, Sasaki Y, et al.: Isolated sleep paralysis elicited by sleep interruption. Sleep 1992, 15:217-225.
-
(1992)
Sleep
, vol.15
, pp. 217-225
-
-
Takeuchi, T.1
Miyasist, A.2
Sasaki, Y.3
-
10
-
-
20244380014
-
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behavior
-
Sakurai T, Amemiya A, Ishii M, et al.: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
-
11
-
-
0008390266
-
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
-
De Lecca L, Kilduff TS, Peyron C, et al.: The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998, 95:322-327.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 322-327
-
-
De Lecca, L.1
Kilduff, T.S.2
Peyron, C.3
-
12
-
-
0032402181
-
Neurons containing hypocretin (orexin) project to multiple neuronal systems
-
Peyron C, Tighe DK, van den Pol AN, et al.: Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998, 18:9996-10015.
-
(1998)
J Neurosci
, vol.18
, pp. 9996-10015
-
-
Peyron, C.1
Tighe, D.K.2
Van Den Pol, A.N.3
-
13
-
-
0033529520
-
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
-
Lin L, Faraco J, Li R, et al.: The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999, 98:365-376.
-
(1999)
Cell
, vol.98
, pp. 365-376
-
-
Lin, L.1
Faraco, J.2
Li, R.3
-
14
-
-
0033588184
-
Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
-
Chemelli RM, Willie JT, Sinton CM, et al.: Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999, 98:437-451.
-
(1999)
Cell
, vol.98
, pp. 437-451
-
-
Chemelli, R.M.1
Willie, J.T.2
Sinton, C.M.3
-
15
-
-
0033971611
-
Hypocretin (orexin) deficiency in human narcolepsy
-
Nishino S, Ripley B, Overeem S, et al.: Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000, 355:39-40.
-
(2000)
Lancet
, vol.355
, pp. 39-40
-
-
Nishino, S.1
Ripley, B.2
Overeem, S.3
-
16
-
-
0033826856
-
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
-
Peyron C, Faraco J, Rogers W, et al.: A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000, 6:991-997.
-
(2000)
Nat Med
, vol.6
, pp. 991-997
-
-
Peyron, C.1
Faraco, J.2
Rogers, W.3
-
17
-
-
0034846670
-
Low CSF hypocretin (orexin) and altered energy homeostasis in human narcolepsy
-
Nishino S, Ripley B, Overeen S, et al.: Low CSF hypocretin (orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 2001, 50:381-388.
-
(2001)
Ann Neurol
, vol.50
, pp. 381-388
-
-
Nishino, S.1
Ripley, B.2
Overeen, S.3
-
19
-
-
0002920546
-
Clinical features of narcolepsy: Japanese experience
-
Edited by Honda Y, Juji T. New York: Springer-Verlag
-
Honda Y: Clinical features of narcolepsy: Japanese experience. In HLA in Narcolepsy. Edited by Honda Y, Juji T. New York: Springer-Verlag; 1988:24-57.
-
(1988)
HLA in Narcolepsy
, pp. 24-57
-
-
Honda, Y.1
-
20
-
-
0036119164
-
CSF hypocretin-1 (orexin- A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia
-
Kanbayashi T, Inoue Y, Chiba S, et al.: CSF hypocretin-1 (orexin- A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res 2002, 11:91-93.
-
(2002)
J Sleep Res
, vol.11
, pp. 91-93
-
-
Kanbayashi, T.1
Inoue, Y.2
Chiba, S.3
-
21
-
-
24944512531
-
Narp immunostaining of human hypocretin (orexin) neurons: Loss in narcolepsy
-
Blouin AM, Thannickal TC, Worley PF, et al.: Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy. Neurology 2005, 65:11189-11192.
-
(2005)
Neurology
, vol.65
, pp. 11189-11192
-
-
Blouin, A.M.1
Thannickal, T.C.2
Worley, P.F.3
-
22
-
-
24944518715
-
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
-
Crocker A, Espana RE, Papdopoulou M, et al.: Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology 2005, 65:1184-1188.
-
(2005)
Neurology
, vol.65
, pp. 1184-1188
-
-
Crocker, A.1
Espana, R.E.2
Papdopoulou, M.3
-
23
-
-
64249130693
-
IGFBP3 colocalizes with and regulates hypocretin (orexin)
-
This article discusses the recent identification of IGFBP3, thereby underscoring selective hypocretin cell death, as opposed to transcription/ biosynthesis or hypocretin peptide processing problems, as the cause of hypocretin deficiency
-
• Honda M, Eriksson KS, Zhang S, et al.: IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS One 2009, 4:e4254. This article discusses the recent identification of IGFBP3, thereby underscoring selective hypocretin cell death, as opposed to transcription/biosynthesis or hypocretin peptide processing problems, as the cause of hypocretin deficiency.
-
(2009)
PLoS One
, vol.4
-
-
Honda, M.1
Eriksson, K.S.2
Zhang, S.3
-
24
-
-
0142025765
-
Elevated antibodies to streptococcal antigens in narcoleptic subjects
-
Billiard M, Laaberki MF, Reygrobellet C, et al.: Elevated antibodies to streptococcal antigens in narcoleptic subjects. Sleep Res 1989, 18:201.
-
(1989)
Sleep Res
, vol.18
, pp. 201
-
-
Billiard, M.1
Laaberki, M.F.2
Reygrobellet, C.3
-
25
-
-
33846840794
-
Narcolepsy with cataplexy
-
This article discusses the possibility that transient autoimmune reaction in the CNS coincides with disease onset despite the failure to find typical autoimmune pathologies or to implicate neuron-specific/organ-specific autoimmune antibodies or IgG reactive to prepro-hypocretin or cleavage products in narcoleptic patients
-
• Dauvilliers Y, Arnulf I, Mignot E: Narcolepsy with cataplexy. Lancet 2007, 369:499-511. This article discusses the possibility that transient autoimmune reaction in the CNS coincides with disease onset despite the failure to find typical autoimmune pathologies or to implicate neuron-specific/organ- specific autoimmune antibodies or IgG reactive to prepro-hypocretin or cleavage products in narcoleptic patients.
-
(2007)
Lancet
, vol.369
, pp. 499-511
-
-
Dauvilliers, Y.1
Arnulf, I.2
Mignot, E.3
-
26
-
-
70349161242
-
Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset
-
This recent, significant study evaluated Streptococcus pyogenes and Helicobacter pylori infections as triggers for narcolepsy. The study compared 200 hypocretin-deficient narcolepsy patients with 200 age-matched controls to find that patients exhibited significantly higher immune response markers close to narcolepsy onset. These findings underscore the probability that streptococcal infections are significant environmental triggers for narcolepsy
-
• Aran A, Lin L, Nevsimalova S, et al.: Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep 2009, 32 (8):979-983. This recent, significant study evaluated Streptococcus pyogenes and Helicobacter pylori infections as triggers for narcolepsy. The study compared 200 hypocretin-deficient narcolepsy patients with 200 age-matched controls to find that patients exhibited significantly higher immune response markers close to narcolepsy onset. These findings underscore the probability that streptococcal infections are significant environmental triggers for narcolepsy.
-
(2009)
Sleep
, vol.32
, Issue.8
, pp. 979-983
-
-
Aran, A.1
Lin, L.2
Nevsimalova, S.3
-
27
-
-
0031912090
-
Genetic and familial aspects of narcolepsy
-
Mignot E: Genetic and familial aspects of narcolepsy. Neurology 1998, 50:S16-S22.
-
(1998)
Neurology
, vol.50
-
-
Mignot, E.1
-
28
-
-
0033673374
-
Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy
-
Hohjoh H, Nakayama T, Ohashi J, et al.: Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy. Tissue Antigens 2000, 56:446-448.
-
(2000)
Tissue Antigens
, vol.56
, pp. 446-448
-
-
Hohjoh, H.1
Nakayama, T.2
Ohashi, J.3
-
29
-
-
0034972378
-
MAO-A and COMT polymorphisms and gene effects in narcolepsy
-
Dauvilliers Y, Neidhart E, Lecendreux M, et al.: MAO-A and COMT polymorphisms and gene effects in narcolepsy. Mol Psychiatry 2001, 6:367-372.
-
(2001)
Mol Psychiatry
, vol.6
, pp. 367-372
-
-
Dauvilliers, Y.1
Neidhart, E.2
Lecendreux, M.3
-
30
-
-
55049121064
-
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
-
These familial and twin studies examining gene polymorphisms associated with narcolepsy specifically indicate that the predictive genes of narcolepsy may exacerbate narcolepsy sleep phenotype and/or engage mechanisms of hypocretin cell death
-
• Miyagawa T, Kawashima M, Nishida N, et al.: Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. Nat Genet 2008, 40:1324-1328. These familial and twin studies examining gene polymorphisms associated with narcolepsy specifically indicate that the predictive genes of narcolepsy may exacerbate narcolepsy sleep phenotype and/or engage mechanisms of hypocretin cell death.
-
(2008)
Nat Genet
, vol.40
, pp. 1324-1328
-
-
Miyagawa, T.1
Kawashima, M.2
Nishida, N.3
-
31
-
-
75749099551
-
Association of TNF-alpha gene promoter polymorphism with narcolepsy-cataplexy in Koreans
-
Park MH, Roh EY, Park H, et al.: Association of TNF-alpha gene promoter polymorphism with narcolepsy-cataplexy in Koreans. Hum Immunol 2004, 65:S110.
-
(2004)
Hum Immunol
, vol.65
-
-
Park, M.H.1
Roh, E.Y.2
Park, H.3
-
33
-
-
0032906867
-
Intracerebroventricular injection of TNF-alpha promotes sleep and is recovered in cervical lymph
-
Dickenstein JB, Moldofsky H, Lue FA, et al.: Intracerebroventricular injection of TNF-alpha promotes sleep and is recovered in cervical lymph. Am J Physiol 1999, 276:R1018-R1022.
-
(1999)
Am J Physiol
, vol.276
-
-
Dickenstein, J.B.1
Moldofsky, H.2
Lue, F.A.3
-
34
-
-
33746472884
-
Genomewide association analysis of human narcolepsy and a new resistance gene
-
Kawashima M, Tamiya G, Oka A, et al.: Genomewide association analysis of human narcolepsy and a new resistance gene. Am J Hum Genet 2006, 79:252-263.
-
(2006)
Am J Hum Genet
, vol.79
, pp. 252-263
-
-
Kawashima, M.1
Tamiya, G.2
Oka, A.3
-
35
-
-
0038757817
-
Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep
-
Tafti M, Petit B, Chollet D, et al.: Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Nat Genet 2003, 34:320-325.
-
(2003)
Nat Genet
, vol.34
, pp. 320-325
-
-
Tafti, M.1
Petit, B.2
Chollet, D.3
-
36
-
-
66649111903
-
Narcolepsy is strongly associated with the T-cell receptor alpha locus
-
Hallmayer J, Faraco J, Lin L, et al.: Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet 2009, 41:708-711.
-
(2009)
Nat Genet
, vol.41
, pp. 708-711
-
-
Hallmayer, J.1
Faraco, J.2
Lin, L.3
-
37
-
-
34250812623
-
Sleep disorders in chronic traumatic brain injury
-
This article identifies percentages of US patients among several million with chronic brain injury who report sleep problems and symptomatic EDS, underscoring the clinical relevance of symptomatic EDS
-
• Verma A, Anand V, Verma NP: Sleep disorders in chronic traumatic brain injury. J Clin Sleep Med 2007, 3:357-362. This article identifies percentages of US patients among several million with chronic brain injury who report sleep problems and symptomatic EDS, underscoring the clinical relevance of symptomatic EDS.
-
(2007)
J Clin Sleep Med
, vol.3
, pp. 357-362
-
-
Verma, A.1
Anand, V.2
Verma, N.P.3
-
38
-
-
0035954346
-
Narcolepsy and low CFS orexin (hypocretin) concentration after diencephalic stroke
-
Scammell TE, Nishino S, Mignot E, et al.: Narcolepsy and low CFS orexin (hypocretin) concentration after diencephalic stroke. Neurology 2001, 56:1751-1753.
-
(2001)
Neurology
, vol.56
, pp. 1751-1753
-
-
Scammell, T.E.1
Nishino, S.2
Mignot, E.3
-
39
-
-
0037096058
-
Secondary narcolepsy in children with brain tumors
-
Marcus CL, Trescher WH, Halbower AC, et al.: Secondary narcolepsy in children with brain tumors. Sleep 200, 25:435-459.
-
Sleep
, vol.200
, Issue.25
, pp. 435-459
-
-
Marcus, C.L.1
Trescher, W.H.2
Halbower, A.C.3
-
40
-
-
10744229433
-
CSF hypocretin levels in Guillain-Barre syndrome and other inflammatory neuropathies
-
Nishino S, Kanbayashi T, Fujiki N, et al.: CSF hypocretin levels in Guillain-Barre syndrome and other inflammatory neuropathies. Neurology 2003, 61:823-825.
-
(2003)
Neurology
, vol.61
, pp. 823-825
-
-
Nishino, S.1
Kanbayashi, T.2
Fujiki, N.3
-
41
-
-
0012149803
-
Secondary narcolepsy in patients with paraneoplastic anti-Ma2 antibodies is associated with hypocretin deficiency
-
Overeem S, Dalmau J, Bataller L, et al.: Secondary narcolepsy in patients with paraneoplastic anti-Ma2 antibodies is associated with hypocretin deficiency. J Sleep Res 2001, 11(Suppl.1):166-167.
-
(2001)
J Sleep Res
, vol.11
, Issue.SUPPL.1
, pp. 166-167
-
-
Overeem, S.1
Dalmau, J.2
Bataller, L.3
-
42
-
-
73549112697
-
Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: New neurochemical and immunological implications
-
The authors report a significant recent study of symptomatic narcolepsy in patients diagnosed with immune-mediated neurologic condition MS with bilateral hypothalamic inflammatory lesions. The findings specifically link the presence of anti-AQP4 antibody and the probability of immuno-attack in hypothalamic periventricular regions to reduced CSF hypocretin-1 levels. Further, they suggest that additional antibody-mediated mechanisms also contribute to secondary hypocretin system impairment, manifesting in EDS symptoms
-
• Kanbayashi T, Shimohata T, Nakashima I, et al.: Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications. Arch Neurol 2009, 66(12):1563-1566. The authors report a significant recent study of symptomatic narcolepsy in patients diagnosed with immune-mediated neurologic condition MS with bilateral hypothalamic inflammatory lesions. The findings specifically link the presence of anti-AQP4 antibody and the probability of immuno-attack in hypothalamic periventricular regions to reduced CSF hypocretin-1 levels. Further, they suggest that additional antibody-mediated mechanisms also contribute to secondary hypocretin system impairment, manifesting in EDS symptoms.
-
(2009)
Arch Neurol
, vol.66
, Issue.12
, pp. 1563-1566
-
-
Kanbayashi, T.1
Shimohata, T.2
Nakashima, I.3
-
43
-
-
0035956531
-
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
-
Ripley B, Fujiki N, Okura M, et al.: CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. Neurology 2001, 57:2253-2258.
-
(2001)
Neurology
, vol.57
, pp. 2253-2258
-
-
Ripley, B.1
Fujiki, N.2
Okura, M.3
-
45
-
-
0344430036
-
The molecular basis of water transport in the brain
-
Amiry-Moghaddam M, Ottersen, OP: The molecular basis of water transport in the brain. Nat Rev Neurosci 2003, 4:991-1001.
-
(2003)
Nat Rev Neurosci
, vol.4
, pp. 991-1001
-
-
Amiry-Moghaddam, M.1
Ottersen, O.P.2
-
46
-
-
23944444890
-
IgG marker of opticspinal multiple sclerosis binds to the aquaporin-4 water channel
-
Lennon VA, Kryzer TJ, Pittock SJ, et al.: IgG marker of opticspinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005, 202:473-477.
-
(2005)
J Exp Med
, vol.202
, pp. 473-477
-
-
Lennon, V.A.1
Kryzer, T.J.2
Pittock, S.J.3
-
47
-
-
1642382070
-
Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin ligand deficient narcoleptic dog
-
Fujiki N, Ripley B, Yoshida Y, et al.: Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin ligand deficient narcoleptic dog. Sleep 2003, 6:953-959.
-
(2003)
Sleep
, vol.6
, pp. 953-959
-
-
Fujiki, N.1
Ripley, B.2
Yoshida, Y.3
-
48
-
-
1842584959
-
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
-
Mieda M, Willie JT, Hara J, et al.: Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A 2004, 101:4649-4654.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4649-4654
-
-
Mieda, M.1
Willie, J.T.2
Hara, J.3
-
49
-
-
48949095544
-
Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy
-
This study demonstrated that supplementation of hypocretin-1 by central administration normalized sleep/wake patterns and behavioral arrest episodes in hypocretin cell-ablated narcoleptic (orexin/ataxin-3) mice. It further demonstrated that exogenous expression of the prepro-hypocretin gene rescued sleep fragmentation and cataplexy in the mice, thus supporting further research aimed toward developing cell transplantation and gene therapy treatment options
-
• Mishima K, Fujiki N, Yoshida Y, et al.: Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. Sleep 2008, 31:1119-1126. This study demonstrated that supplementation of hypocretin-1 by central administration normalized sleep/wake patterns and behavioral arrest episodes in hypocretin cell-ablated narcoleptic (orexin/ataxin-3) mice. It further demonstrated that exogenous expression of the prepro-hypocretin gene rescued sleep fragmentation and cataplexy in the mice, thus supporting further research aimed toward developing cell transplantation and gene therapy treatment options.
-
(2008)
Sleep
, vol.31
, pp. 1119-1126
-
-
Mishima, K.1
Fujiki, N.2
Yoshida, Y.3
-
50
-
-
0034984017
-
Hypocretin levels in sporadic and familial cases of canine narcolepsy
-
Ripley B, Fujiki N, Okura M, et al.: Hypocretin levels in sporadic and familial cases of canine narcolepsy. Neurobiol Dis 2001, 8:525-534.
-
(2001)
Neurobiol Dis
, vol.8
, pp. 525-534
-
-
Ripley, B.1
Fujiki, N.2
Okura, M.3
-
51
-
-
4243122995
-
Case study: Effect of hypocretin ligand replacement therapy in a 3-year-old Weimaraner with narcolepsy
-
Schatzberg SJ, Cutter-Schatzberg K, Nydam D, et al.: Case study: effect of hypocretin ligand replacement therapy in a 3-year-old Weimaraner with narcolepsy. J Vet Intern Med 2004, 18:586-588.
-
(2004)
J Vet Intern Med
, vol.18
, pp. 586-588
-
-
Schatzberg, S.J.1
Cutter-Schatzberg, K.2
Nydam, D.3
-
52
-
-
53149147775
-
Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice
-
Liu M, Thankachan S, Kaur S, et al.: Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice. Eur J Neurosci 2008, 28:1382-1393.
-
(2008)
Eur J Neurosci
, vol.28
, pp. 1382-1393
-
-
Liu, M.1
Thankachan, S.2
Kaur, S.3
-
53
-
-
11144348186
-
Transplant of hypocretin neurons into the pontine reticular formation: Primary results
-
Arias-Carrion O, Murillo-Rodriguez E, Xu M, et al.: Transplant of hypocretin neurons into the pontine reticular formation: primary results. Sleep 2004, 27:1465-1470.
-
(2004)
Sleep
, vol.27
, pp. 1465-1470
-
-
Arias-Carrion, O.1
Murillo-Rodriguez, E.2
Xu, M.3
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