Substrate-induced changes in protease active site conformation impact on subsequent reactions with substrates

Journal of Biological Chemistry

Volumn 285, Issue 30, 2010, Pages 22950-22956

  Pan, Rong ^a   Zhang, Xue Jing ^a,b   Zhang, Zi Jian ^a,c   Zhou, Yuan ^a,c   Tian, Wei Xi ^c   He, Rong Qiao ^a,c  

^a INSTITUTE OF BIOPHYSICS   (China)

^b INSTITUTE OF PSYCHOLOGY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ADAPTIVE VALUE; BIOCHEMICAL REACTIONS; CHROMOGENIC SUBSTRATE; CONFORMATIONAL CHANGE; EISENIA FETIDA; ENZYMATIC CATALYSIS; ENZYMATIC REACTION; HIGH EFFICIENCY; INDUCED FIT; INTRINSIC FLUORESCENCE; LIVING SYSTEMS; LOCK-AND-KEY; LOW CONCENTRATIONS; NATIVE ENZYMES;

CONFORMATIONS; ENZYME ACTIVITY; ENZYMES; FLUORESCENCE; KEYS (FOR LOCKS);

SUBSTRATES;

PROTEINASE; PROTEINASE 1; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EARTHWORM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CATALYTIC DOMAIN; OLIGOCHAETA; OLIGOPEPTIDES; PEPTIDE HYDROLASES; SUBSTRATE SPECIFICITY;

EISENIA FETIDA;

EID: 77954900239     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.103549     Document Type: Article

References (24)

1. Fischer, E. (1894) Ber. Dt. Chem. Ges. 27, 2985-2993
2. Koshland, D. E. (1958) Proc. Natl. Acad. Sci. U.S.A. 44, 98-104
3. Yao, Q. Z., Tian, M., and Tsou, C. L. (1984) Biochemistry 23, 2740-2744
4. Davies, D. R., and Cohen, G. H. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 7-12
5. Sundberg, E. J., and Mariuzza, R. A. (2000) Structure 8, R137-R142
6. Tsou, C. L. (1993) Science 262, 380-381
7. Somorjai, G. A. (2004) Nature 430, 730
8. Anderson, C. M., Zucker, F. H., and Steitz, T. A. (1979) Science 204, 375-380
9. Hritz, J., de Ruiter, A., and Oostenbrink, C. (2008) J. Med. Chem. 51, 7469-7477
10. Koska, J., Spassov, V. Z., Maynard, A. J., Yan, L., Austin, N., Flook, P. K., and Venkatachalam, C. M. (2008) J. Chem. Inf. Model 48, 1965-1973
11. Matsushima, N., Yoshida, H., Kumaki, Y., Kamiya, M., Tanaka, T., Izumi, Y., and Kretsinger, R. H. (2008) Curr. Protein Pept. Sci. 9, 591-610
12. Bakan, A., and Bahar, I. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 14349-14354
13. Swift, R. V., and McCammon, J. A. (2009) J. Am. Chem. Soc. 131, 5126-5133
14. Weikl, T. R., and von Deuster, C. (2009) Proteins 75, 104-110
15. Sullivan, S. M., and Holyoak, T. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 13829-13834
16. Okazaki, K., and Takada, S. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 11182-11187
17. Boehr, D. D., Nussinov, R., and Wright, P. E. (2009) Nat. Chem. Biol. 5, 789-796
18. Wu, J. X., Zhao, X. Y., Pan, R., and He, R. Q. (2007) Int. J. Biol. Macromol. 40, 399-406
19. Zhao, J., Pan, R., He, J., Liu, Y., Li, D. F., and He, R. Q. (2007) J. Biomed. Biotechnol. 40, 97654
20. Zhao, J., Xiao, R., He, J., Pan, R., Fan, R., Wu, C., Liu, X., Liu, Y., and He, R. Q. (2007) Int. J. Biol. Macromol. 40, 67-75
21. Nelson, D. L., and Cox, M. M. (2000) Lehninger Principles of Biochemistry 3/e Version, Freeman, New York
22. Li, Y. C., Chiang, C. W., Yeh, H. C., Hsu, P. Y., Whitby, F. G., Wang, L. H., and Chan, N. L. (2008) J. Biol. Chem. 283, 2917-2926
23. Yaremchuk, A., Tukalo, M., Grøtli, M., and Cusack, S. (2001) J. Mol. Biol. 309, 989-1002
24. Berger, C., Weber-Bornhauser, S., Eggenberger, J., Hanes, J., Plückthun, A., and Bosshard, H. R. (1999) FEBS Lett. 450, 149-153