Effects of ATRA combined with citrus and ginger-derived compounds in human SCC xenografts

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Kleiner Hancock, Heather E ^a   Shi, Runhua ^a,b   Remeika, Angela ^a   Robbins, Delira ^a   Prince, Misty ^a   Gill, Jennifer N ^a   Syed, Zanobia ^a   Adegboyega, Patrick ^a,b   Mathis, J Michael ^a   Clifford, John L ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Louisiana State University School of Medicine Shreveport   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1' ACETOXYCHAVICOL ACETATE; ANTINEOPLASTIC AGENT; AURAPTENE; B RAF KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; RETINOIC ACID; STAT3 PROTEIN; UNCLASSIFIED DRUG; 1'-ACETOXYCHAVICOL ACETATE; BENZYL ALCOHOL DERIVATIVE; COUMARIN DERIVATIVE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER PREVENTION; CITRUS FRUIT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; GINGER; HUMAN; HUMAN CELL; HUMAN TISSUE; MONOTHERAPY; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION INITIATION; TUMOR VOLUME; ANIMAL; DRUG COMBINATION; DRUG SCREENING; GENETICS; MALE; METABOLISM; MOUSE MUTANT; PATHOLOGY; SKIN TUMOR; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZYL ALCOHOLS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CITRUS; COUMARINS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; GINGER; HUMANS; LIPOPOLYSACCHARIDES; LUCIFERASES; MALE; MICE; MICE, SCID; NF-KAPPA B; PLANT EXTRACTS; SKIN NEOPLASMS; TRETINOIN; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77954876959     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-394     Document Type: Article

References (44)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics, 2009. CA Cancer J Clin 2009, 59(4):225-49. 10.3322/caac.20006, 19474385.
2. Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001, 344(13):975-983. 10.1056/NEJM200103293441306, 11274625.
3. Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006, 441(7092):431-436. 10.1038/nature04870, 16724054.
4. Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004, 6(3):203-208. 10.1016/j.ccr.2004.09.003, 15380510.
5. Kondo A, Ohigashi H, Murakami A. A potent inhibitor of tumor promoter-induced Epstein-Barr virus activation, 1'-acetoxychavicol acetate from Languas galanga, a traditional Thai condiment. Bioscience Biotechnology Biochemistry 1993, 57:1344-1345.
6. Murakami A, Ohura S, Nakamura Y, Koshimizu K, Ohigashi H. 1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin. Oncology 1996, 53(5):386-391. 10.1159/000227593, 8784473.
7. Ichikawa H, Takada Y, Murakami A, Aggarwal BB. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol 2005, 174(11):7383-7392.
8. Murakami A, Kuki W, Takahashi Y, Yonei H, Nakamura Y, Ohto Y, Ohigashi H, Koshimizu K. Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes. Jpn J Cancer Res 1997, 88(5):443-452.
9. Jun DY, Kim JS, Park HS, Han CR, Fang Z, Woo MH, Rhee IK, Kim YH. Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade. Carcinogenesis 2007, 28(6):1303-1313. 10.1093/carcin/bgm028, 17301064.
10. Yu L, Zhang DM. [Studies on chemical constituents from fruits of Paliurus ramosissimus]. Zhongguo Zhong Yao Za Zhi 2006, 31(24):2049-2052.
11. Murakami A, Ohigashi H. Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells. Biol Chem 2006, 387(4):387-392. 10.1515/BC.2006.052, 16606336.
12. Kawabata K, Murakami A, Ohigashi H. Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice. Biosci Biotechnol Biochem 2006, 70(12):3062-3065. 10.1271/bbb.60393, 17151446.
13. Kohno H, Suzuki R, Curini M, Epifano F, Maltese F, Gonzales SP, Tanaka T. Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Int J Cancer 2006, 118(12):2936-2942. 10.1002/ijc.21719, 16395701.
14. Kuroyanagi K, Kang MS, Goto T, Hirai S, Ohyama K, Kusudo T, Yu R, Yano M, Sasaki T, Takahashi N, et al. Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2008, 366(1):219-225. 10.1016/j.bbrc.2007.11.119, 18060855.
15. Takahashi Y, Inaba N, Kuwahara S, Kuki W, Yamane K, Murakami A. Rapid and convenient method for preparing aurapten-enriched product from hassaku peel oil: implications for cancer-preventive food additives. J Agric Food Chem 2002, 50(11):3193-3196. 10.1021/jf011628b, 12009985.
16. Clagett-Dame M, DeLuca HF. The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr 2002, 22:347-381. 10.1146/annurev.nutr.22.010402.102745E, 12055350.
17. Maden M, Hind M. Retinoic acid, a regeneration-inducing molecule. Dev Dyn 2003, 226(2):237-244. 10.1002/dvdy.10222, 12557202.
18. Love JM, Gudas LJ. Vitamin A, differentiation and cancer. Curr Opin Cell Biol 1994, 6(6):825-831. 10.1016/0955-0674(94)90051-5, 7880529.
19. Chen L-C, De Luca LM. Retinoid effects on skin cancer. Skin Cancer: Mechanisms and human relevance 1994, 401-424. Boca Raton: CRC Press, Mukhtar H.
20. Verma AK. Inhibition of both stage I and stage II mouse skin tumour promotion by retinoic acid and the dependence of inhibition of tumor promotion on the duration of retinoic acid treatment. Cancer Res 1987, 47(19):5097-5101.
21. Cheepala SB, Yin W, Syed Z, Gill JN, McMillian A, Kleiner HE, Lynch M, Loganantharaj R, Trutschl M, Cvek U, et al. Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion. Mol Cancer 2009, 8:27. 10.1186/1476-4598-8-27, 2685120, 19432991.
22. Syed Z, Cheepala SB, Gill JN, Stein J, Nathan CA, DiGiovanni J, Batra V, Adegboyega P, Kleiner HE, Clifford JL. All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis. Cancer Prevention Research 2009, 2:903-911. 10.1158/1940-6207.CAPR-09-0041, 19789299.
23. Carlsen H, Moskaug JO, Fromm SH, Blomhoff R. In vivo imaging of NF-kappa B activity. J Immunol 2002, 168(3):1441-1446.
24. Barwick T, Bencherif B, Mountz JM, Avril N. Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation. Nucl Med Commun 2009, 30(12):908-917. 10.1097/MNM.0b013e32832ee93b, 19794320.
25. Martin SJ, Eisenbarth JA, Wagner-Utermann U, Mier W, Henze M, Pritzkow H, Haberkorn U, Eisenhut M. A new precursor for the radiosynthesis of [18F]FLT. Nucl Med Biol 2002, 29(2):263-273. 10.1016/S0969-8051(01)00289-X, 11823132.
26. Habig WH, Jakoby WB. Assays for differentiation of glutathione S-transferases. Methods Enzymol 1981, 77:398-405. full_text, 7329316.
27. Kleiner HE, Vulimiri SV, Miller L, Johnson WH, Whitman CP, DiGiovanni J. Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice. Carcinogenesis 2001, 22(1):73-82. 10.1093/carcin/22.1.73, 11159744.
28. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.
29. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249(22):7130-7139.
30. Prochaska HJ, Talalay P. Purification and characterization of two isofunctional forms of NAD(P)H: quinone reductase from mouse liver. J Biol Chem 1986, 261(3):1372-1378.
31. Kawabata K, Tanaka T, Yamamoto T, Ushida J, Hara A, Murakami A, Koshimizu K, Ohigashi H, Stoner GD, Mori H. Suppression of N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis by dietary feeding of 1'-acetoxychavicol acetate. Jpn J Cancer Res 2000, 91(2):148-155.
32. Nakamura Y, Murakami A, Ohto Y, Torikai K, Tanaka T, Ohigashi H. Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate. Cancer Res 1998, 58(21):4832-4839.
33. Tanaka T, Kawabata K, Kakumoto M, Makita H, Matsunaga K, Mori H, Satoh K, Hara A, Murakami A, Koshimizu K, et al. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate. Jpn J Cancer Res 1997, 88(9):821-830.
34. Ohnishi M, Tanaka T, Makita H, Kawamori T, Mori H, Satoh K, Hara A, Murakami A, Ohigashi H, Koshimizu K. Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis. Jpn J Cancer Res 1996, 87(4):349-356.
35. Prince M, Li Y, Childers A, Itoh K, Yamamoto M, Kleiner HE. Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice. Toxicol Lett 2009, 185(3):180-186. 10.1016/j.toxlet.2008.12.014, 2676710, 19150646.
36. Murakami A, Wada K, Ueda N, Sasaki K, Haga M, Kuki W, Takahashi Y, Yonei H, Koshimizu K, Ohigashi H. In vitro absorption and metabolism of a citrus chemopreventive agent, auraptene, and its modifying effects on xenobiotic enzyme activities in mouse livers. Nutr Cancer 2000, 36(2):191-199. 10.1207/S15327914NC3602_8, 10890030.
37. Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995, 30(6):445-600. 10.3109/10409239509083491, 8770536.
38. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003, 3(10):768-780. 10.1038/nrc1189, 14570043.
39. Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 2007, 21(11):1396-1408. 10.1101/gad.1553707, 1877751, 17510282.
40. Lee H, Herrmann A, Deng JH, Kujawski M, Niu G, Li Z, Forman S, Jove R, Pardoll DM, Yu H. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 2009, 15(4):283-293. 10.1016/j.ccr.2009.02.015, 2777654, 19345327.
41. Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 2009, 15(10):3423-3432. 10.1158/1078-0432.CCR-08-2822, 19417020.
42. Wang XJ, Hayes JD, Henderson CJ, Wolf CR. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc Natl Acad Sci USA 2007, 104(49):19589-19594. 10.1073/pnas.0709483104, 2148333, 18048326.
43. Hu L, Miao W, Loignon M, Kandouz M, Batist G. Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies. Cancer Chemother Pharmacol 2010, 66(3):467-74. 10.1007/s00280-009-1182-7, 19940992.
44. Tan KP, Kosuge K, Yang M, Ito S. NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity. Free Radic Biol Med 2008, 45(12):1663-1673. 10.1016/j.freeradbiomed.2008.09.010, 18845239.