Next generation OP-bioscavengers: A circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 253-258

  Kronman, Chanoch ^a   Cohen, Ofer ^a   Mazor, Ohad ^a   Ordentlich, Arie ^a   Raveh, Lily ^a   Velan, Baruch ^a   Shafferman, Avigdor ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Acetylcholinesterase; Hypolysine AChE; OP bioscavenger; Pharmacokinetics; Polyethylene glycol

Indexed keywords

ACETYLCHOLINESTERASE ANTIBODY; ALANINE; ANTIDOTE; DRUG ANTIBODY; EPITOPE; MACROGOL; MUTANT PROTEIN; ORGANOPHOSPHATE; PHENYLALANINE; RECOMBINANT HUMAN ACETYLCHOLINESTERASE; RECOMBINANT HYPOLYSINE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG ELIMINATION; DRUG FORMULATION; DRUG MEGADOSE; EMBRYO; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTOXICATION; MACACA; MALE; MOUSE; NONHUMAN;

ANIMALIA; MACACA MULATTA; MUS; RODENTIA;

EID: 77954867337     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.12.004     Document Type: Article

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