Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants

Journal of Biological Chemistry

Volumn 282, Issue 49, 2007, Pages 35491-35501

  Cohen, Ofer ^a   Kronman, Chanoch ^a   Lazar, Arie ^a   Velan, Baruch ^a   Shafferman, Avigdor ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE HYPOLYSINE MUTANTS; BIOSCAVENGERS; CIRCULATORY LONGEVITY; SIALIC ACID;

ANTIBODIES; ENZYME ACTIVITY; IMMUNOLOGY;

POLYETHYLENE GLYCOLS;

ACETYLCHOLINESTERASE; HYPOLYSINE; MACROGOL; MUTANT PROTEIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CLEARANCE; CONTROLLED STUDY; EMBRYO; ENZYME ASSAY; ENZYME MECHANISM; HUMAN; HUMAN CELL; IMMUNOGENICITY; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN;

ACETYLCHOLINESTERASE; ANIMALS; ANTIBODIES; ASIALOGLYCOPROTEIN RECEPTOR; CELL LINE; HUMANS; MICE; MICE, INBRED ICR; MUTATION; PHOSPHORIC ACID ESTERS; POLYETHYLENE GLYCOLS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIALIC ACIDS;

EID: 37249059261     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704785200     Document Type: Article

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