Validated LC-MS (ESI) assay for the simultaneous determination of amitriptyline and its metabolite nortriptyline in rat plasma: Application to a pharmacokinetic comparison

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 3, 2010, Pages 735-739

  Shen, Yuan ^a   Zhu, Rong Hua ^a   Li, Huan De ^a   Liu, Yan Wen ^a   Xu, Ping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Amitriptyline; HPLC MS ESI; Nortriptyline; Pharmacokinetics; Rat plasma

Indexed keywords

ACETONITRILE; AMITRIPTYLINE; AMMONIUM ACETATE; DRUG METABOLITE; FORMIC ACID; NORTRIPTYLINE; SODIUM HYDROXIDE; TERT BUTYL METHYL ETHER; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; NORTRIPTYLINE; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77954860341     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.04.031     Document Type: Article

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