Vane's discovery of the mechanism of action of aspirin changed our understanding of its clinical pharmacology

Pharmacological Reports

Volumn 62, Issue 3, 2010, Pages 518-525

  Botting, Regina M ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Analgesia; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 3; Diclofenac; Hypothermia; Paracetamol

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYCLOOXYGENASE 3; DICLOFENAC; FLURBIPROFEN; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; TOLFENAMIC ACID; TUMOR NECROSIS FACTOR ALPHA; CYCLOOXYGENASE 1; CYCLOOXYGENASE-3; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; CEREBROVASCULAR ACCIDENT; CLINICAL PHARMACOLOGY; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; DRUG PROTEIN BINDING; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME STRUCTURE; HEART INFARCTION; HUMAN; IMMUNE RESPONSE; LOW DRUG DOSE; MOLECULAR WEIGHT; NEPHROTOXICITY; NONHUMAN; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS INHIBITION; REVIEW; STOMACH MUCOSA LESION; THROMBOCYTE AGGREGATION INHIBITION; ANIMAL; GENETICS; INTRON; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; HUMANS; INTRONS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 77954850148     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(10)70308-X     Document Type: Review

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