Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

Molecular Endocrinology

Volumn 24, Issue 5, 2010, Pages 1062-1076

  Argetsinger, Lawrence S ^a   Stuckey, Jeanne A ^a   Robertson, Scott A ^a   Koleva, Rositsa I ^b,c   Cline, Joel M ^a   Marto, Jarrod A ^b,c   Myers Jr , Martin G ^a   Carter Su, Christin ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GROWTH HORMONE; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; PHOSPHOPEPTIDE; PROTEIN TYROSINE PHOSPHATASE 1B; SRC HOMOLOGY 2B1BETA; STAT3 PROTEIN; STAT5B PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CHIMERA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; MASS SPECTROMETRY; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CELL LINE; GROWTH HORMONE; HUMANS; IMMUNOPRECIPITATION; JANUS KINASE 2; MICE; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TANDEM MASS SPECTROMETRY; TYROSINE;

EID: 77954845356     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0355     Document Type: Article

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