Ghrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesity

Annals of Thoracic Medicine

Volumn 5, Issue 3, 2010, Pages 161-165

  Ursavas, Ahmet ^a   Ilcol, Yesim Ozarda ^a   Nalci, Nazan ^a   Karadag, Mehmet ^a   Ege, Ercument ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Adipokines; obesity; sleep apnea

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GHRELIN; LEPTIN; RESISTIN;

ADULT; APNEA HYPOPNEA INDEX; ARTICLE; BLOOD LEVEL; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; EPWORTH SLEEPINESS SCALE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; POLYSOMNOGRAPHY; SLEEP APNEA SYNDROME; STATISTICAL SIGNIFICANCE; VENOUS BLOOD;

EID: 77954835095     PISSN: 18171737     EISSN: 19983557     Source Type: Journal    
DOI: 10.4103/1817-1737.65050     Document Type: Article

References (32)

1. ASDA-Diagnostic Classification Steering Committee. The international classification of sleep disorders. Diagnostic and Coding Manual. 2nd ed. Lawrance, KS: Allen Press Inc; 1997.
2. Strollo PJ Jr, Rogers RM. Obstructive sleep apnea. N Engl J Med 1996;334:99-104.
3. Malhotra A, White DP. Obstructive sleep apnoea. Lancet 2002;360:237-245
4. Alam I, Lewis K, Stephens JW, Baxter JN. Obesity, metabolic syndrome and sleep apnoea: All pro-inflammatory states. Obes Rev 2007;8:119-127
5. Auwerx J, Staels B. Leptin. Lancet 1998;351:737-742
6. Masaki T, Chiba S, Tatsukawa H, Yasuda T, Noguchi H, Seike M, et al. Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. Hepatology 2004;40:177-184
7. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001;50:1714-1719
8. Lebovitz HE. The relationship of obesity to the metabolic syndrome. Int J Clin Pract Suppl 2003;134:18-27.
9. Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: An update. Clin Endocrinol (Oxf) 2006;64:355-365
10. O'Donnell CP, Tankersley CG, Polotsky VP, Schwartz AR, Smith PL. Leptin, obesity, and respiratory function. Respir Physiol 2000;119:163-170
11. Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: More than just another fat cell hormone? Diabetes Care 2003;26:2442-2450
12. Söderberg S, Ahrén B, Jansson JH, Johnson O, Hallmans G, Asplund K, et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999;246:409-418
13. Aizawa-Abe M, Ogawa Y, Masuzaki H, Ebihara K, Satoh N, Iwai H, et al. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest 2000;105:1243-1252
14. Allan Rechtschaffen In: Rechtschaffen A, Kales A, editors. A manual of standardized terminology, tecniques and scoring system for sleep stages of human subjects. 3rd ed. Los Angeles: Brain Research Institute; 1973. p. 1-13.
15. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-295
16. Ip MS, Lam KS, Ho C, Tsang KW, Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 2000;118:580-586
17. Tatsumi K, Kasahara Y, Kurosu K, Tanabe N, Takiguchi Y, Kuriyama T. Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome. Chest 2005;127:716-721 (Pubitemid 40775497)
18. Shimura R, Tatsumi K, Nakamura A, Kasahara Y, Tanabe N, Takiguchi Y, et al. Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest 2005;127:543-549 (Pubitemid 40229315)
19. Shimizu K, Chin K, Nakamura T, Masuzaki H, Ogawa Y, Hosokawa R, et al. Plasma leptin levels and cardiac sympathetic function in patients with obstructive sleep apnoea-hypopnoea syndrome. Thorax 2002;57:429-434
20. Barceló A, Barbé F, Llompart E, de la Peña M, Durán-Cantolla J, Ladaria A, et al. Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: Role of obesity. Am J Respir Crit Care Med 2005;171:183-187
21. Sharma SK, Kumpawat S, Goel A, Banga A, Ramakrishnan L, Chaturvedi P. Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep-disordered breathing. Sleep Med 2007;8:12-17
22. Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME. Adiponectin differntially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun 2004;316:924-929
23. Zhang XL, Yin KS, Wang H, Su S. Serum adiponectin levels in adult male patients with obstructive sleep apnea hypopnea syndrome. Respiration 2006;73:73-77
24. Makino S, Handa H, Suzukawa K, Fujiwara M, Nakamura M, Muraoka S, et al. Obstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance. Clin Endocrinol (Oxf) 2006;64:12-19
25. Tauman R, Serpero LD, Capdevila OS, O'Brien LM, Goldbart AD, Kheirandish-Gozal L, et al. Adipokines in children with sleep disordered breathing. Sleep 2007;30:443-449
26. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-312
27. Harsch IA, Koebnick C, Wallaschofski H, Schahin SP, Hahn EG, Ficker JH, et al. Resistin levels in patients with obstructive sleep apnoea syndrome-the link to subclinical inflammation? Med Sci Monit 2004;10:CR510-5.
28. Harsch IA, Bergmann T, Koebnick C, Wiedmann R, Ruderich F, Hahn EG, et al. Adiponectin, resistin and subclinical inflammation-the metabolic burden in Launois Bensaude syndrome, a rare form of obesity. J Physiol Pharmacol 2007;58:65-76.
29. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001;50:707-709 (Pubitemid 32242624)
30. Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. Sleep loss: A novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol 2005;99:2008-2019
31. Harsch IA, Konturek PC, Koebnick C, Kuehnlein PP, Fuchs FS, Pour Schahin S, et al. Leptin and ghrelin levels in patients with obstructive sleep apnoea: Effect of CPAP treatment. Eur Respir J 2003;22:251-257
32. Ulukavak Ciftci T, Kokturk O, Bukan N, Bilgihan A. Leptin and ghrelin levels in patients with obstructive sleep apnea syndrome. Respiration 2005;72:395-401. (Pubitemid 41160173)