Osteoprotegerin and nuclear factor-kappaB ligand are associated with leptin and adiponectin levels, in apparently healthy women

Journal of Musculoskeletal Neuronal Interactions

Volumn 10, Issue 2, 2010, Pages 174-179

  Tenta, R ^a   Panagiotakos, D B ^a   Fragopoulou, E ^a   Nomikos, T ^a   Pitsavos, C ^b   Chrysohoou, C ^b   Antonopoulou, S ^a   Stefanadis, C ^b  

^a HAROKOPIO UNIVERSITY   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Adipokines; Metabolism; Opg; Physiology; RANKL

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; LEPTIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

ADULT; AGE; AGED; ARTICLE; BLOOD ANALYSIS; BODY MASS; BONE TURNOVER; CONTROLLED STUDY; CORRELATIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; NORMAL HUMAN; PHYSIOLOGICAL PROCESS; POSTMENOPAUSE; PREMENOPAUSE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; WOMEN'S HEALTH;

ADIPONECTIN; ADOLESCENT; ADULT; AGE FACTORS; AGED; BODY MASS INDEX; DATABASES, FACTUAL; DIET; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LEPTIN; LIFE STYLE; MIDDLE AGED; OSTEOPROTEGERIN; RANK LIGAND;

EID: 77954828807     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Hadjidakis DJ, Androulakis, II. Bone remodeling. Ann N Y Acad Sci 2006;1092:385-96.
2. Martin RB. Is all cortical bone remodeling initiated by microdamage? Bone 2002;30:8-13.
3. Gori F, Hofbauer LC, Dunstan CR, Spelsberg TC, Khosla S, Riggs BL. The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated. Endocrinology 2000;141:4768-76.
4. Wittrant Y, Theoleyre S, Chipoy C, et al. RANKL/ RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis. Biochim Biophys Acta 2004;1704:49-57.
5. Hamrick MW, Ferrari SL. Leptin and the sympathetic connection of fat to bone. Osteoporos Int 2007.
6. Takeda S, Karsenty G. Central control of bone formation. J Bone Miner Metab 2001;19:195-8.
7. Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003;148:293-300.
8. Berner HS, Lyngstadaas SP, Spahr A, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004;35:842-9.
9. Pitsavos C, Panagiotakos DB, Chrysohoou C, Stefanadis C. Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study. BMC Public Health 2003;3:32.
10. Craig CL, Marshall AL, Sjostrom M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35:1381-95.
11. Pedrera-Zamorano JD, Lavado-Garcia JM, Roncero-Martin R, Calderon-Garcia JF, Rodriguez-Dominguez T, Canal-Macias ML. Effect of beer drinking on ultrasound bone mass in women. Nutrition 2009;25:1057-63.
12. Ilich JZ, Brownbill RA, Tamborini L, Crncevic-Orlic Z. To drink or not to drink: how are alcohol, caffeine and past smoking related to bone mineral density in elderly women? J Am Coll Nutr 2002;21:536-44.
13. Uemura H, Yasui T, Miyatani Y, et al. Circulating osteoprotegerin is associated with age and systolic blood pressure, but not with lipid profile or fasting glucose, in postmenopausal women. Menopause 2008;15:180-4.
14. Zhong N, Wu XP, Xu ZR, et al. Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta 2005;351:161-8.
15. Peng XD, Xie H, Zhao Q, Wu XP, Sun ZQ, Liao EY. Relationships between serum adiponectin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in Chinese men. Clin Chim Acta 2008;387:31-5.
16. Samelson EJ, Broe KE, Demissie S, et al. Increased plasma osteoprotegerin concentrations are associated with Metab 2008;93:1789-95.
17. Gordeladze JO, Reseland JE. A unified model for the action of leptin on bone turnover. J Cell Biochem 2003;88:706-12.
18. Martin A, David V, Malaval L, Lafage-Proust MH, Vico L, Thomas T. Opposite effects of leptin on bone metabolism: a dose-dependent balance related to energy intake and insulin-like growth factor-I pathway. Endocrinology 2007;148:3419-25.
19. Siepi D, Marchesi S, Vaudo G, et al. Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin. Metabolism 2008;57:321-5.
20. Kontogianni MD, Dafni UG, Routsias JG, Skopouli FN. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res 2004;19:546-51.
21. Richards JB, Valdes AM, Burling K, Perks UC, Spector TD. Serum adiponectin and bone mineral density in women. J Clin Endocrinol Metab 2007;92:1517-23.
22. Luo XH, Guo LJ, Xie H, et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 2006;21:1648-56.
23. Gannage-Yared MH, Yaghi C, Habre B, et al. Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study. Eur J Endocrinol 2008;158:353-9.
24. Oshima K, Nampei A, Matsuda M, et al. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005;331:520-6.
25. Yamaguchi N, Kukita T, Li YJ, et al. Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans. FEMS Immunol Med Microbiol 2007;49:28-34.
26. Hamdy NA. Targeting the RANK/RANKL/OPG signaling pathway: a novel approach in the management of osteoporosis. Curr Opin Investig Drugs 2007;8:299-303.
27. Hofbauer LC, Schoppet M. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. Jama 2004;292:490-5.
28. Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 2002;147:173-80.
29. Diamond FB Jr, Cuthbertson D, Hanna S, Eichler D. Correlates of adiponectin and the leptin/adiponectin ratio in obese and non-obese children. J Pediatr Endocrinol Metab 2004;17:1069-75.
30. Inoue M, Maehata E, Yano M, Taniyama M, Suzuki S. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism 2005;54:281-6.