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Volumn 1704, Issue 2, 2004, Pages 49-57

RANKL/RANK/OPG: New therapeutic targets in bone tumours and associated osteolysis

Author keywords

OPG; RANK; Tumour

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN; RECEPTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B PROTEIN; RECOMBINANT OSTEOPROTEGERIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 4444257291     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbcan.2004.05.002     Document Type: Review
Times cited : (211)

References (67)
  • 2
    • 0018120428 scopus 로고
    • Direct resorption of bone by human breast cancer cells in vitro
    • Eilon G., Mundy G.R. Direct resorption of bone by human breast cancer cells in vitro. Nature. 276:1978;726-728
    • (1978) Nature , vol.276 , pp. 726-728
    • Eilon, G.1    Mundy, G.R.2
  • 8
    • 0001076087 scopus 로고    scopus 로고
    • Osteoprotegerin: A new therapeutic agent for the treatment of bone disease
    • Grimaud E., Rédini F., Heymann D. Osteoprotegerin: a new therapeutic agent for the treatment of bone disease. Drug Discov. Today. 6:2001;1241-1242
    • (2001) Drug Discov. Today , vol.6 , pp. 1241-1242
    • Grimaud, E.1    Rédini, F.2    Heymann, D.3
  • 9
    • 0036200116 scopus 로고    scopus 로고
    • Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors
    • Good C.R., O'Keefe R.J., Puzas J.E., Schwarz E.M., Rosier R.N. Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors. J. Surg. Oncol. 79:2002;174-179
    • (2002) J. Surg. Oncol. , vol.79 , pp. 174-179
    • Good, C.R.1    O'Keefe, R.J.2    Puzas, J.E.3    Schwarz, E.M.4    Rosier, R.N.5
  • 11
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N., Bataille R., Mancini C., Lazzaretti M., Barillé S. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood. 98:2001;3527-3533
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3    Lazzaretti, M.4    Barillé, S.5
  • 13
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia A.N., Atkins G.J., To L.B., Pan B., Horvath N., Kostakis P., Findlay D.M., Bardy P., Zannettino A.C. Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res. 63:2003;5438-5445
    • (2003) Cancer Res. , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3    Pan, B.4    Horvath, N.5    Kostakis, P.6    Findlay, D.M.7    Bardy, P.8    Zannettino, A.C.9
  • 21
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB ligand- osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E., Szydlo R., Apperley J.F., Hatjiharissi E., Politou M., Meletis J., Viniou N., Yataganas X., Goldman J.M., Rahemtulla A. Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood. 102:2003;1064-1069
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3    Hatjiharissi, E.4    Politou, M.5    Meletis, J.6    Viniou, N.7    Yataganas, X.8    Goldman, J.M.9    Rahemtulla, A.10
  • 22
    • 0037079719 scopus 로고    scopus 로고
    • Mechanism of hypercalcemia in adult T-cell leukemia: Overexpression of receptor activator of nuclear factor kB ligand on adult T-cell leukemia cells
    • Nosaka K., Miyamoto T., Sakai T., Mitsuya H., Suda T., Matsuoka M. Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kB ligand on adult T-cell leukemia cells. Blood. 99:2002;634-640
    • (2002) Blood , vol.99 , pp. 634-640
    • Nosaka, K.1    Miyamoto, T.2    Sakai, T.3    Mitsuya, H.4    Suda, T.5    Matsuoka, M.6
  • 23
    • 0036845366 scopus 로고    scopus 로고
    • Tumour cells produce receptor activator of NF-kB ligand (RANKL) in skeletal metastases
    • Huang L., Cheng Y.Y., Chow L.T.C., Zheng M.H., Kumta S.M. Tumour cells produce receptor activator of NF-kB ligand (RANKL) in skeletal metastases. J. Clin. Pathol. 55:2002;877-878
    • (2002) J. Clin. Pathol. , vol.55 , pp. 877-878
    • Huang, L.1    Cheng, Y.Y.2    Chow, L.T.C.3    Zheng, M.H.4    Kumta, S.M.5
  • 24
    • 0037303695 scopus 로고    scopus 로고
    • Bone markers in the management of patients with skeletal metastases
    • Demers L.M. Bone markers in the management of patients with skeletal metastases. Cancer. 97:2003;874-879
    • (2003) Cancer , vol.97 , pp. 874-879
    • Demers, L.M.1
  • 25
    • 0036773564 scopus 로고    scopus 로고
    • RANK ligand is a prerequesite for cancer-associated osteolytic lesions
    • Kitazawa S., Kitazawa R. RANK ligand is a prerequesite for cancer-associated osteolytic lesions. J. Pathol. 198:2002;228-236
    • (2002) J. Pathol. , vol.198 , pp. 228-236
    • Kitazawa, S.1    Kitazawa, R.2
  • 26
  • 27
    • 0345831221 scopus 로고    scopus 로고
    • Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic and osteolytic lesions in bone
    • Lee Y., Schwarz E., Davies M., Jo M., Gates J., Wu J., Zhang X., Lieberman J.R. Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic and osteolytic lesions in bone. J. Orthop. Res. 21:2003;62-72
    • (2003) J. Orthop. Res. , vol.21 , pp. 62-72
    • Lee, Y.1    Schwarz, E.2    Davies, M.3    Jo, M.4    Gates, J.5    Wu, J.6    Zhang, X.7    Lieberman, J.R.8
  • 30
    • 0037086077 scopus 로고    scopus 로고
    • Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells
    • Holen I., Croucher P.I., Hamdy F.C., Eaton C.L. Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells. Cancer Res. 62:2002;1619-1623
    • (2002) Cancer Res. , vol.62 , pp. 1619-1623
    • Holen, I.1    Croucher, P.I.2    Hamdy, F.C.3    Eaton, C.L.4
  • 31
    • 0034771689 scopus 로고    scopus 로고
    • Osteoprotegerin in serum as a novel marker of bone metastatic spread in prostate cancer
    • Jung K., Lein M., von Hösslin K., Brux B., Schnorr D., Loening S.A., Sinha P. Osteoprotegerin in serum as a novel marker of bone metastatic spread in prostate cancer. Clin. Chem. 47:2001;2061-2063
    • (2001) Clin. Chem. , vol.47 , pp. 2061-2063
    • Jung, K.1    Lein, M.2    Von Hösslin, K.3    Brux, B.4    Schnorr, D.5    Loening, S.A.6    Sinha, P.7
  • 32
    • 0242440212 scopus 로고    scopus 로고
    • Serum osteoprotegerin and receptor activator of nuclear factor-kappa B Ligand as indicators of disturbed osteoclastogenesis in patients with prostate cancer
    • Jung K., Stephan C., Semjonow A., Lein M., Schnorr D., Loening A. Serum osteoprotegerin and receptor activator of nuclear factor-kappa B Ligand as indicators of disturbed osteoclastogenesis in patients with prostate cancer. J. Urol. 170:2003;2302-2305
    • (2003) J. Urol. , vol.170 , pp. 2302-2305
    • Jung, K.1    Stephan, C.2    Semjonow, A.3    Lein, M.4    Schnorr, D.5    Loening, A.6
  • 33
    • 0037374460 scopus 로고    scopus 로고
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
    • Shipman C.M., Croucher P.I. Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res. 63:2003;912-916
    • (2003) Cancer Res. , vol.63 , pp. 912-916
    • Shipman, C.M.1    Croucher, P.I.2
  • 35
    • 0033873632 scopus 로고    scopus 로고
    • Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kB in giant cell tumor of bone
    • Huang L., Xu J., Wood D.J., Zheng M.H. Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kB in giant cell tumor of bone. Am. J. Pathol. 156:2000;761-767
    • (2000) Am. J. Pathol. , vol.156 , pp. 761-767
    • Huang, L.1    Xu, J.2    Wood, D.J.3    Zheng, M.H.4
  • 37
    • 0037395314 scopus 로고    scopus 로고
    • Receptor activator of NF-kappaB ligand (RANKL) is expressed in chondroblastoma: Possible involvement in osteoclastic giant cell recruitment
    • Huang L., Cheng Y.Y., Chow L.T., Zheng M.H., Kumta S.M. Receptor activator of NF-kappaB ligand (RANKL) is expressed in chondroblastoma: possible involvement in osteoclastic giant cell recruitment. Mol. Pathol. 56:2003;116-120
    • (2003) Mol. Pathol. , vol.56 , pp. 116-120
    • Huang, L.1    Cheng, Y.Y.2    Chow, L.T.3    Zheng, M.H.4    Kumta, S.M.5
  • 38
    • 0035009069 scopus 로고    scopus 로고
    • Osteolysis and cancer
    • Goltzman D. Osteolysis and cancer. J. Clin. Invest. 107:2001;1219-1220
    • (2001) J. Clin. Invest. , vol.107 , pp. 1219-1220
    • Goltzman, D.1
  • 39
    • 0033757999 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor-bone interactions in osteolytic metastases
    • Chirgwin J.M., Guise T.A. Molecular mechanisms of tumor-bone interactions in osteolytic metastases. Crit. Rev. Eukaryot. Gene Expr. 10:2000;159-178
    • (2000) Crit. Rev. Eukaryot. Gene Expr. , vol.10 , pp. 159-178
    • Chirgwin, J.M.1    Guise, T.A.2
  • 40
    • 0034684978 scopus 로고    scopus 로고
    • Interactions between cancer and bone marrow cells induce osteoclast differentiation factor expression and osteoclast-like cell formation in vitro
    • Chikatsu N., Takeuchi Y., Tamura Y., Fukumoto S., Yano K., Tsuda E., Ogata E., Fujita T. Interactions between cancer and bone marrow cells induce osteoclast differentiation factor expression and osteoclast-like cell formation in vitro. Biochem. Biophys. Res. Commun. 267:2000;632-637
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , pp. 632-637
    • Chikatsu, N.1    Takeuchi, Y.2    Tamura, Y.3    Fukumoto, S.4    Yano, K.5    Tsuda, E.6    Ogata, E.7    Fujita, T.8
  • 43
    • 0034861109 scopus 로고    scopus 로고
    • Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells
    • Mancino A.T., Klimberg V.S., Yamamoto M., Manolagas S.C., Abe E. Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells. J. Surg. Res. 100:2001;18-24
    • (2001) J. Surg. Res. , vol.100 , pp. 18-24
    • Mancino, A.T.1    Klimberg, V.S.2    Yamamoto, M.3    Manolagas, S.C.4    Abe, E.5
  • 44
    • 0038485707 scopus 로고    scopus 로고
    • Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis
    • Ohshiba T., Miyaura C., Inada M., Ito A. Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis. Br. J. Cancer. 88:2003;1318-1326
    • (2003) Br. J. Cancer , vol.88 , pp. 1318-1326
    • Ohshiba, T.1    Miyaura, C.2    Inada, M.3    Ito, A.4
  • 47
    • 0034673525 scopus 로고    scopus 로고
    • Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation
    • Nagai M., Kyakumoto S., Sato N. Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation. Biochem. Biophys. Res. Commun. 269:2000;532-536
    • (2000) Biochem. Biophys. Res. Commun. , vol.269 , pp. 532-536
    • Nagai, M.1    Kyakumoto, S.2    Sato, N.3
  • 48
    • 0035866399 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma
    • Michigami T., Ihara-Watanabe M., Yamazaki M., Ozono K. Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma. Cancer Res. 61:2001;1637-1644
    • (2001) Cancer Res. , vol.61 , pp. 1637-1644
    • Michigami, T.1    Ihara-Watanabe, M.2    Yamazaki, M.3    Ozono, K.4
  • 49
    • 0142250340 scopus 로고    scopus 로고
    • Transforming growth factor-beta in osteolytic breast cancer bone metastases
    • Guise T.A., Chirgwin J.M. Transforming growth factor-beta in osteolytic breast cancer bone metastases. Clin. Orthop. 415:2003;S32-38
    • (2003) Clin. Orthop. , vol.415 , pp. 32-38
    • Guise, T.A.1    Chirgwin, J.M.2
  • 50
    • 0742306404 scopus 로고    scopus 로고
    • Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix
    • Blum B., Moseley J., Miller L., Richelsoph K., Haggard W. Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix. Orthopedics. 27:2004;S161-S165
    • (2004) Orthopedics , vol.27
    • Blum, B.1    Moseley, J.2    Miller, L.3    Richelsoph, K.4    Haggard, W.5
  • 51
    • 4444237576 scopus 로고
    • Un modèle experimental d'ostéosarcome chez le rat: II. L'ostéosarcome greffable du rat
    • Thiéry J.-P., Perdereau B., Gongora R., Gongora G., Mazabraud A. Un modèle experimental d'ostéosarcome chez le rat: II. L'ostéosarcome greffable du rat. Sem. Hôp. Paris. 58:1982;1686-1689
    • (1982) Sem. Hôp. Paris , vol.58 , pp. 1686-1689
    • Thiéry, J.-P.1    Perdereau, B.2    Gongora, R.3    Gongora, G.4    Mazabraud, A.5
  • 53
    • 0032404069 scopus 로고    scopus 로고
    • Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy
    • Akatsu T., Murakami T., Ono K., Nishikawa M., Tsuda E., Mochizuki S.I., Fujise N., Higashio K., Motoyoshi K., Yamamoto M., Nagata N. Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy. Bone. 23:1998;495-498
    • (1998) Bone , vol.23 , pp. 495-498
    • Akatsu, T.1    Murakami, T.2    Ono, K.3    Nishikawa, M.4    Tsuda, E.5    Mochizuki, S.I.6    Fujise, N.7    Higashio, K.8    Motoyoshi, K.9    Yamamoto, M.10    Nagata, N.11
  • 55
    • 0034319084 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice
    • Clohisy D.R., Ramnaraine M.L., Scully S., Qi M., Van G., Tan H.L., Lacey D.L. Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice. J. Orthop. Res. 18:2000;967-976
    • (2000) J. Orthop. Res. , vol.18 , pp. 967-976
    • Clohisy, D.R.1    Ramnaraine, M.L.2    Scully, S.3    Qi, M.4    Van, G.5    Tan, H.L.6    Lacey, D.L.7
  • 56
    • 0037303261 scopus 로고    scopus 로고
    • Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease
    • Croucher P.I., Shipman C.M., Van Camp B., Vanderkerken K. Bisphosphonates and osteoprotegerin as inhibitors of myeloma bone disease. Cancer. 97:2003;818-824
    • (2003) Cancer , vol.97 , pp. 818-824
    • Croucher, P.I.1    Shipman, C.M.2    Van Camp, B.3    Vanderkerken, K.4
  • 58
    • 0037728969 scopus 로고    scopus 로고
    • Osteoprotegerin/osteoclastogenesis inhibitory factor decreases human prostate cancer burden in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice
    • Yonou H., Kanomata N., Goya M., Kamijo T., Yokose T., Hasebe T., Nagai K., Hatano T., Ogawa Y., Ochiai A. Osteoprotegerin/osteoclastogenesis inhibitory factor decreases human prostate cancer burden in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice. Cancer Res. 63:2003;2096-2102
    • (2003) Cancer Res. , vol.63 , pp. 2096-2102
    • Yonou, H.1    Kanomata, N.2    Goya, M.3    Kamijo, T.4    Yokose, T.5    Hasebe, T.6    Nagai, K.7    Hatano, T.8    Ogawa, Y.9    Ochiai, A.10
  • 64
    • 0344844468 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone
    • Zhang J., Dai J., Yao Z., Lu Y., Dougall W., Keller E.T. Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone. Cancer Res. 63:2003;7883-7890
    • (2003) Cancer Res. , vol.63 , pp. 7883-7890
    • Zhang, J.1    Dai, J.2    Yao, Z.3    Lu, Y.4    Dougall, W.5    Keller, E.T.6
  • 65
    • 0037303260 scopus 로고    scopus 로고
    • RANK-Fc: A therapeutic antagonist for RANKL in myeloma
    • Sordillo E.M., Pearse R.N. RANK-Fc: a therapeutic antagonist for RANKL in myeloma. Cancer. 97:2003;802-812
    • (2003) Cancer , vol.97 , pp. 802-812
    • Sordillo, E.M.1    Pearse, R.N.2
  • 66
    • 0037302195 scopus 로고    scopus 로고
    • Receptor activator of NF-kB ligand, macrophage inflammatory protein-1alpha, and the proteasome: Novel therapeutic targets in myeloma
    • Oyajobi B.O., Mundy G.R. Receptor activator of NF-kB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma. Cancer. 97:2003;813-817
    • (2003) Cancer , vol.97 , pp. 813-817
    • Oyajobi, B.O.1    Mundy, G.R.2
  • 67
    • 4444293930 scopus 로고    scopus 로고
    • Disabling of RANK receptor complex by novel osteoprotegerin like peptidomimetics restores bone loss in-vivo
    • Cheng X., Kinosaki M., Takami M., Choi Y., Zhang H., Murali R. Disabling of RANK receptor complex by novel osteoprotegerin like peptidomimetics restores bone loss in-vivo. J. Biol. Chem. 84:2004;274-277
    • (2004) J. Biol. Chem. , vol.84 , pp. 274-277
    • Cheng, X.1    Kinosaki, M.2    Takami, M.3    Choi, Y.4    Zhang, H.5    Murali, R.6


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