Selection of affibody molecules to the ligand-binding site of the insulin-like growth factor-1 receptor

Biotechnology and Applied Biochemistry

Volumn 55, Issue 2, 2010, Pages 99-109

  Li, Jingjing ^a   Lundberg, Emma ^a   Vernet, Erik ^a   Larsson, Barbro ^b   Höidén Guthenberg, Ingmarie ^b   Gräslund, Torbjörn ^a  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b Affibody AB   (Sweden)

Author keywords

Affibody molecule; Competitive elution; Insulin like growth factor 1 receptor (IGF 1R); Phage display

Indexed keywords

BIOPANNING; CELL EXTRACTS; CYTOMETRY; DISPLAY TECHNOLOGIES; DOSE-DEPENDENT; ELISA-BASED ASSAYS; INHIBITORY EFFECT; INSULIN-LIKE GROWTH FACTOR-1; INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-1R); INSULIN-LIKE GROWTH FACTOR-1 RECEPTORS; LIGAND-BINDING SITES; MCF-7 CELLS; NANOMOLAR; ON FLOW; PHAGE DISPLAY; QUALITATIVE ANALYSIS;

BINDING ENERGY; BIOACTIVITY; COMPETITION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; INSULIN; PEPTIDES; SITE SELECTION;

MOLECULES;

AFFIBODY; IMIDAZOLE; REAGENT; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIOPHAGE; BINDING AFFINITY; BINDING COMPETITION; BINDING KINETICS; BINDING SITE; BIOPANNING; BIOTINYLATION; CARCINOMA CELL; CELL GROWTH; CELL PROLIFERATION; COMPETITION; ELUTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; MOLECULAR MECHANICS; PHAGE DISPLAY; PHAGEMID; PROTEIN ANALYSIS; PROTEIN PURIFICATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MICE; RECEPTOR, IGF TYPE 1; SINGLE-CHAIN ANTIBODIES;

EID: 77954828431     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20090226     Document Type: Article

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