Highly enantioselective michael addition of cyclic 1,3-Dicarbonyl compounds to β,γ-Unsaturated α-Keto esters

Advanced Synthesis and Catalysis

Volumn 352, Issue 10, 2010, Pages 1648-1652

  Chen, Xing Kuan ^a,b   Zheng, Chang Wu ^b   Zhao, Sheng Li ^b   Chai, Zhuo ^b   Yang, Ying Quan ^b   Zhao, Gang ^b   Cao, Wei Guo ^a  

^a SHANGHAI UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

, unsaturated keto esters; 1,3 dicarbonyl compounds; Michael addition; Organocatalysis; Thioureas

Indexed keywords

EID: 77954798320     PISSN: 16154150     EISSN: 16154169     Source Type: Journal    
DOI: 10.1002/adsc.201000045     Document Type: Article

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72. Two acyclic 1,3-dicarbonyl compounds were also tested but with inferior results: acetylacetone (48 h, 41% yield, 83% ee) and ethyl acetoacetate (48 h, trace conversion).