Lentivirus-mediated gene transfer of small interfering RNA against the chemokine receptor CXCR3 suppresses cytokine indicators of acute graft rejection in a rat model

Journal of International Medical Research

Volumn 38, Issue 3, 2010, Pages 1113-1120

  Bao, C R ^a   Tang, G Y ^b   Zhang, X P ^b   Quan, Z W ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

Acute graft rejection; Animal model; Chemokine receptors; CXCR3; Cytokines; Lentivirus; Liver transplantation; Small interfering RNA

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LENTIVIRUS VECTOR; MESSENGER RNA; SMALL INTERFERING RNA; CXCR3 PROTEIN, RAT; CYTOKINE;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG TARGETING; GENE EXPRESSION; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LYMPHOCYTE FUNCTION; MALE; MORBIDITY; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; WISTAR RAT; ANIMAL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; GRAFT REJECTION; IMMUNOLOGY; LENTIVIRINAE; METABOLISM; PATHOLOGY;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GRAFT REJECTION; LENTIVIRUS; LIVER TRANSPLANTATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR3; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 77954787372     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001003800340     Document Type: Article

References (19)

1. Verdonk RC, van den Berg AP, Slooff MJH, et al: Liver transplantation: an update. Neth J Med 2007; 65: 372-380.
2. Ma Y, Wang G, He X, et al: Clinical and pathological analysis of acute rejection following orthotopic liver transplantation. Chin Med J (Engl) 2009; 122: 1400-1403.
3. Pan TL, Chen CL, Lin CL, et al: Ceruloplasmin, a novel candidate as a diagnostic marker for liver function after liver transplantation. Transplant Proc 2000; 32: 2198.
4. Melter M, McMahon G, Fang J, et al: Current understanding of chemokine involvement in allograft transplantation. Pediatr Transplant 1999; 3: 10-21.
5. Nelson PJ, Krensky AM: Chemokines, chemokine receptors, and allograft rejection. Immunity 2001; 14: 377-386.
6. Sallusto F, Mackay CR, Lanzavecchia A: The role of chemokine receptors in primary effector, and memory responses. Annu Rev Immunol 2000; 18: 593-620.
7. Reinders ME, Laning JC, Paul LC, et al: The role of chemokines in transplant immunology. Transplant Rev 2003; 17: 87-95.
8. Schnickel GT, Hsieh GR, Garcia C, et al: Role of CXCR3 and CCR5 in allograft rejection. Transplant Proc 2006; 38: 3221-3224.
9. Hancock WW, Gao W, Faia KL, et al: Chemokines and their receptors in allograft rejection. Curr Opin Immunol 2000; 12: 511-516.
10. Abbas-Terki T, Blanco-Bose W, Deglon N, et al: Lentiviral-mediated RNA interference. Hum Gene Ther 2002; 13: 2197-2201.
11. Kamada N, Calne RY: A surgical experience with five hundred thirty liver transplants in the rat. Surgery 1983; 93: 64-69.
12. Zhi X, Chen S, Zhou P, et al: RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion. Clin Exp Metastasis 2007; 24: 439-448.
13. Nelson PJ, Krensky AM: Chemokines, chemokine receptors, and allograft rejection. Immunity 2001; 14: 377-386.
14. Baggiolini M: Chemokines in pathology and medicine. J Intern Med 2001; 250: 91-104.
15. Baggiolini M: Chemokines and leukocyte traffic. Nature 1998; 392: 565-568.
16. Baggiolini M, Dewald B, Moser B: Human chemokines: an update. Annu Rev Immunol 1997; 15: 675-705.
17. Hancock WW, Gao W, Csizmadia V, et al: Donor-derived IP-10 initiates development of acute allograft rejection. J Exp Med 2001; 193: 975-980.
18. Hancock WW, Lu B, Gao W, et al: Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 2000; 192: 1515-1520.
19. Gao W, Faia KL, Csizmadia V, et al: Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 2001; 72: 1199-1205.