Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay

Toxicology in Vitro

Volumn 24, Issue 3, 2010, Pages 1026-1031

  Wille, T ^a   Thiermann, H ^a   Worek, F ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; Automated assay; Detoxification; High throughput; Organophosphorus compounds; Screening

Indexed keywords

ACETYLCHOLINESTERASE; CYCLODEXTRIN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; SARIN;

ARTICLE; AUTOMATION; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; GUINEA PIG; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; RABBIT; RAT; REPRODUCIBILITY; RHESUS MONKEY; ROBOTICS;

ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL MARKERS; BIOLOGICAL WARFARE AGENTS; CHOLINESTERASE REACTIVATORS; CYCLODEXTRINS; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; GUINEA PIGS; HUMANS; MACACA MULATTA; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHORIC TRIESTER HYDROLASES; RABBITS; RATS; ROBOTICS; SARIN; SOFTWARE; SPECIES SPECIFICITY; SWINE;

EID: 77649192492     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.11.023     Document Type: Article

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