Efficient on-column conversion of IgG1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography

Journal of Chromatography A

Volumn 1217, Issue 32, 2010, Pages 5225-5232

  Aono, Hiromasa ^a   Wen, Dingy ^a   Zang, Li ^a   Houde, Damian ^a   Pepinsky, R Blake ^a   Evans, David R H ^a  

^a BIOGEN   (United States)

Author keywords

Affinity chromatography; Cysteine; Disulfide; IgG1; Peptide mapping; Trisulfide

Indexed keywords

AFFINITY COLUMN; CYSTEINE; DISULFIDE BONDS; HEAVY AND LIGHT CHAINS; HIGH EFFICIENCY; HYDROGEN/DEUTERIUM EXCHANGE; IN-VITRO; MOLECULAR HETEROGENEITY; MONOCLONAL ANTIBODIES (MAB); PEPTIDE MAPPING; PROTEIN A; SULFUR ATOMS;

AFFINITY CHROMATOGRAPHY; DIFFERENTIAL SCANNING CALORIMETRY; ELECTROPHORESIS; MAPPING; MONOCLONAL ANTIBODIES; PEPTIDES; PROTEIN FOLDING; SULFUR;

COLUMN CHROMATOGRAPHY;

CYSTEINE; DEUTERIUM; DISULFIDE; HYDROGEN; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; SULFIDE; THIOL DERIVATIVE; TRISULFIDE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G; STAPHYLOCOCCUS PROTEIN A;

AFFINITY CHROMATOGRAPHY; ANTIGEN BINDING; ARTICLE; BINDING KINETICS; CAPILLARY ELECTROPHORESIS; CHEMICAL MODIFICATION; CHO CELL; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISULFIDE BOND; HEAVY CHAIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIGHT CHAIN; MASS SPECTROMETRY; PEPTIDE MAPPING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN A AFFINITY CHROMATOGRAPHY; PROTEIN FOLDING; PURIFICATION; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; DEUTERIUM HYDROGEN EXCHANGE; HAMSTER; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; OXIDATION REDUCTION REACTION; PROCEDURES; TIME;

ANIMALS; ANTIBODIES, MONOCLONAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CRICETINAE; CRICETULUS; CYSTEINE; DEUTERIUM EXCHANGE MEASUREMENT; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; OXIDATION-REDUCTION; PEPTIDE MAPPING; STAPHYLOCOCCAL PROTEIN A; SULFIDES; TIME FACTORS;

EID: 77954761601     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.06.029     Document Type: Article

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