Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71]

Journal of Steroid Biochemistry and Molecular Biology

Volumn 121, Issue 1-2, 2010, Pages 25-28

  Hatakeyama, Susumi ^a   Yoshino, Madoka ^a   Eto, Kohei ^a   Takahashi, Keisuke ^a   Ishihara, Jun ^a   Ono, Yoshiyuki ^b   Saito, Hitoshi ^b   Kubodera, Noboru ^b  

^a NAGASAKI UNIVERSITY   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

1 ,25 Dihydroxy 2 (3 hydroxypropoxy)vitamin D3; 1 ,25 Dihydroxyvitamin D3; 20 Epi eldecalcitol; Active vitamin D3; ED 71; Eldecalcitol

Indexed keywords

1 EPI ELDECALCITOL; 1,3 DIEPI ELDECALCITOL; 3 EPI ELDECALCITOL; [20 EPI 1 ALPHA,25 DIHYDROXY 2 BETA (3 HYDROXYPROPOXY)VITAMIN D3; CALCITRIOL; COLECALCIFEROL DERIVATIVE; METHYL GROUP; OSTEOCALCIN; UNCLASSIFIED DRUG; 2-(3-HYDROXYPROPOXY)-1,25-DIHYDROXYVITAMIN D3; CALCITRIOL RECEPTOR; ELDECALCITOL; VITAMIN D;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMICAL REACTION; CONTROLLED STUDY; DIASTEREOISOMER; DRUG ACTIVITY; DRUG SYNTHESIS; HISTIOCYTIC LYMPHOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; MYELOID LEUKEMIA; OSTEOSARCOMA CELL; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; HL 60 CELL LINE; MEDICINAL CHEMISTRY; OSTEOPOROSIS; SYNTHESIS; TUMOR CELL LINE; U937 CELL LINE;

CALCITRIOL; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HL-60 CELLS; HUMANS; MODELS, CHEMICAL; OSTEOCALCIN; OSTEOPOROSIS; RECEPTORS, CALCITRIOL; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS; VITAMIN D;

EID: 77954757628     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.03.041     Document Type: Article

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