Synthesis and evaluation of a 3-position diastereomer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 8050-8056

  Hatakeyama, Susumi ^a   Nagashima, Satoshi ^a   Imai, Naoko ^a   Takahashi, Keisuke ^a   Ishihara, Jun ^a   Sugita, Atsuko ^b   Nihei, Takeshi ^b   Saito, Hitoshi ^b   Takahashi, Fumiaki ^b   Kubodera, Noboru ^b  

^a NAGASAKI UNIVERSITY   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

1 ,25 Dihydroxy 2 (3 hydroxypropoxy)vitamin D3; 1 ,25 Dihydroxyvitamin D3; 3 epi ED 71; ED 71

Indexed keywords

2BETA (3 HYDROXYPROPOXY)CALCITRIOL; 3 EPI 2BETA (3 HYDROXYPROPOXY) 1ALPHA,25 DIHYDROXYVITAMIN D3; CALCITRIOL; COLECALCIFEROL DERIVATIVE; PARATHYROID HORMONE; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HORMONE RELEASE; IN VITRO STUDY; NONHUMAN; PARATHYROID CELL;

ANIMALS; CATTLE; CHOLECALCIFEROL; PARATHYROID GLANDS; PARATHYROID HORMONE; PROTEIN BINDING; RECEPTORS, CALCITRIOL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BOS TAURUS;

EID: 33750035196     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.039     Document Type: Article

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