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Relative binding affinity of calcitriol, ED-71 and l-epi-ED-71 for DBP and vitamin D receptor (VDR) are as follows; DBP: calcitriol: 100, ED-71: 410, l-epi-ED-71: 670 (normalized by the potency of calcitriol=100). VDR: calcitriol: 100, ED-71: 70, l-epi-ED-71: 0.3 (normalized by the potency of calcitriol=100).
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