Alterations of Lewis histo-blood group antigen expression in cancer cells;Zmiany ekspresji antygenów grupowych układu Lewis w komórkach nowotworowych

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 64, Issue , 2010, Pages 87-99

  Kaczmarek, Radosław ^a,b  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^b Uniwersytetu Wrocławskiego ^*  (Poland)

Author keywords

Carcinogenesis; Fucosyltransferases; Lewis blood group system; Lewis histo blood group antigens

Indexed keywords

BLOOD; BLOOD GROUP LEWIS SYSTEM; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; NEOPLASM; REVIEW; UPREGULATION;

GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEWIS BLOOD-GROUP SYSTEM; NEOPLASMS; UP-REGULATION;

EID: 77954756382     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: None     Document Type: Review

References (92)

1. Arends J. W., Verstynen C., Bosman F. T., Hilgers J., Stȩplewski Z.: Distribution of monoclonal antibody-defined monosialoganglioside in normal and cancerous human tissues: an immunoperoxidase study. Hybridoma, 1983;2:219-229 (Pubitemid 13050954)
2. Atkinson B. F., Ernst C. S., Herlyn M., Stȩplewski Z., Sears H. F., Koprowski H.: Gastrointestinal cancer-associated antigen in immunoperoxidase assay. Cancer Res., 1982;42:4820-4823 (Pubitemid 13205999)
3. Aubert M., Panicot L., Crotte C., Gibier P., Lombardo D., Sadoulet M. O., Mas E.: Restoration of α (1, 2) fucosyltransferase activity decreases adhesive and metastatic properties of human pancreatic cancer cells. Cancer Res., 2000;60:1449-1456 (Pubitemid 30152020)
4. Ayroldi E., Cannarile L., Migliorati G., Bartoli A., Nicoletti I., Riccardi C.: CD44 (Pgp-l) inhibits CD3 and dexamethasone-induced apoptosis. Blood, 1995;86:2672-2678
5. Barthel S. R., Wiese G. K., Cho J., Opperman M. J., Hays D. L., Siddiqui J., Pienta K. J., Furie B., Dimitroff C. J.: Alpha 1, 3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc. Natl. Acad. Sci. USA, 2009;106:19491-19496
6. Becker D. J., Lowe J. B.: Fucose: biosynthesis and biological function in mammals. Glycobiology, 2003;13:41R-53R (Pubitemid 36850123)
7. Błach-Olszewska Z.: Mechanizmy kontroli odporności wrodzonej. Post. Hig. Med. Dośw., 2006;60:201-208
8. y and eliminate Lewisy-positive human carcinoma cells and xenografts. Clin. Cancer. Res., 2004;10:4538-4549 (Pubitemid 38878898)
9. Boisteau O., Gautier F., Cordel S., Henry F., Harb J., Douillard J. Y., Vallette F. M., Mefah K., Grégoire M.: Apoptosis induced by sodium butyrate treatment increases immunogenicity of a rat colon tumor cell line. Apoptosis, 1997;2:403-412 (Pubitemid 127504724)
10. Chandrasekan E. V., Chawda R., Locke R. D., Piskorz C. F., Matta K. L.: Biosynthesis of the carbohydrate antigenic determinants, Globo H., blood group H., and Lewis b: a role for prostate cancer cell a1, 2-L-fucosyltransferase. Glycobiology, 2002;12:153-162 (Pubitemid 34567861)
11. Chen G. Y., Osada H., Santamaria-Babi L. F., Kannagi R.: Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Proc. Natl. Acad. Sci. USA, 2006;103:16894-16899 (Pubitemid 44737349)
12. Chhieng D. C., Rodriguez-Burford C., Talley L. I., Sviglin H., Stockard C. R., Kleinberg M. J., Barnes M. N., Partridge E. E., Khazaeli M. B., Grizzle W. E.: Expression of CEA, Tag-72, and Lewis-Y antigen in primary and metastatic lesions of ovarian carcinoma. Hum. Pathol., 2003;34:1016-1021 (Pubitemid 37315253)
13. Comin C. E., Novelli L., Boddi V., Paglierani M., Dini S.: Calretinin, thrombomodulin, CEA, and CD15: a useful combination of immunohistochemical markers for differentiating pleural epithelial mesothelioma from peripheral pulmonary adenocarcinoma. Hum. Pathol., 2001;32:529-536 (Pubitemid 32506524)
14. Da̧browska A., Baczyńska D., Widerak K., Laskowska A., Ugorski M.: Promoter analysis of the human α1, 3/4-fucosyltransferase gene (FUT III). Biochim. Biophys. Acta, 2005;1731:66-73 (Pubitemid 41463602)
15. Dettke M., Pàlfi G., Loibner H.: Activation-dependent expression of the blood group-related Lewis Y antigen on peripheral blood granulocytes. J. Leukoc. Biol., 2000;68:511-514
16. Elola M. T., Capurro M. I., Barrio M. M., Coombs P. J., Taylor M. E., Drickamer K., Mordoh J.: Lewis x antigen mediates adhesion of human breast carcinoma cells to activated endothelium: possible involvement of the endothelial scavenger receptor C-type lectin. Breast Cancer Res. Treat., 2007;101:161-174 (Pubitemid 46115422)
17. Engel U., McCombs R., Stranahan P., Pettijohn D., Hage E.: Decrease in Lewisx expression in esophageal adenocarcinomas arising in Barrett's Epithelium. Cancer Epidemiol. Biomarkers Prev., 1997;6:245-248 (Pubitemid 27172889)
18. Escrevente C., Machado E., Brito C., Reis C. A., Stoeck A., Runz S., Marmè A., Altevogt P., Costa J.: Different expression levels of α3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines. Int. J. Oncol., 2006;29:557-566
19. Feinberg H., Taylor M. E., Weis W. I.: Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis (x) by a novel mechanism. J. Biol. Chem., 2007;282:17250-17258 (Pubitemid 47093219)
20. Ferens-Sieczkowska M., Kossowska B.: Haptoglobin fucosylation in ascites fluids of ovarian cancer patients. Adv. Clin. Exp. Med., 2004;13:581-587 (Pubitemid 39220463)
21. Fujiwara Y., Shimada M., Takenaka K., Kajiyama K., Shirabe K., Sugimachi K.: The Sialyl Lewis X expression in hepatocarcinogenesis: potential predictor for the emergence of hepatocellular carcinoma. Hepatogastroenterology, 2002;49:213-217 (Pubitemid 34289521)
22. Fukushima K.: Expression of Lewisx, sialylated Lewisx, Lewisa, and sialylated Lewisa antigens in human lung carcinoma. Tohoku J. Exp. Med., 1991;163:17-30
23. x as a new tumor-associated antigen. Cancer Res., 1984;44:5279-5285 (Pubitemid 15204501)
24. Fuster M. M., Esko J. D.: The sweet and sour of cancer: glycans as novel therapeutic targets. Nature, 2005;5:526-542 (Pubitemid 40942829)
25. Futamura N., Nakamura S., Tatematsu M., Yamamura Y., Kannagi R., Hirose H.: Clinicopathologic significance of sialyl Lex expression in advanced gastric carcinoma. Br. J. Cancer, 2000;83:1681-1687 (Pubitemid 32001714)
26. Goła̧b J., Jakóbisiak M., Lasek W.: Immunologia, Wydawnictwo Naukowe PWN, Warszawa, 2008
27. Goupille C., Hallouin F., Meflah K., Le Pendu J.: Increase of rat colon carcinoma cells tumorigenicity by α (1-2) fucosyltransferase gene transfection. Glycobiology, 1997;7:221-229 (Pubitemid 27168777)
28. Goupille C., Marionneau S., Bureau V., Hallouin F., Meichenin M., Rocher J., Le Pendu J.: α1, 2Fucosyltransferase increases resistance to apoptosis of rat colon carcinoma cells. Glycobiology, 2000;10:375-382 (Pubitemid 30184608)
29. Günthert A. R., Sträter J., von Reyher U., Henne C., Joos S., Koretz K., Moldenhauer G., Krammer P. H., Möller P.: Early detachment of colon carcinoma cells during CD95 (APO-1/Fas)-mediated apoptosis I. De-adhesion from hyaluronate by shedding of CD44. J. Cell Biol., 1996;134:1089-1096 (Pubitemid 26278230)
30. Handa K., Takatani-Nakase T., Larue L., Stemmler M. P., Kemler R., Hakomori S. I.: Le (x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note. Biochem. Biophys. Res. Commun., 2007;358:247-252 (Pubitemid 46719110)
31. Hansson G. C., Karlsson K. A., Larson G., McKibbin J. M., Błaszczyk M., Herlyn M., Stȩplewski Z., Koprowski H.: Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. J. Biol. Chem., 1983;258:4091-4097
32. Hellström I., Garrigues H. J., Garrigues U., Hellström K. E.: Highly tumor-reactive, internalizing, mouse monoclonal antibodies to Leyrelated cell surface antigens. Cancer Res., 1990;50:2183-2190 (Pubitemid 20115097)
33. Inaba Y., Ohyama C., Kato T., Satoh M., Saito H., Hagisawa S., Takahashi T., Endoh M., Fukuda M. N., Arai Y., Fukuda M.: Gene transfer of alpha1, 3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells. Int. J. Cancer, 2003;107:949-957 (Pubitemid 37429836)
34. Jørgensen T., Berner A., Kaalhus O., Tveter K. J., Danielsen H. E., Bryne M.: Up-regulation of the oligosaccharide sialyl Lewisx: a new prognostic parameter in metastatic prostate cancer. Cancer Res., 1995;55:1817-1819
35. Kannagi R.: Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer. Glycoconj. J., 1997;14:577-584 (Pubitemid 27353201)
36. Kannagi R.: Molecular mechanism for cancer-associated induction of sialyl Lewis X and sialyl Lewis A expression-The Warburg effect revisited. Glycoconj. J., 2004;20:353-364 (Pubitemid 39024043)
37. Kannagi R., Izawa M., Koike T., Miyazaki K., Kimura N.: Carbohydratemediated cell adhesion in cancer metastasis and angiogenesis. Cancer Sci., 2004;95:377-384 (Pubitemid 38832679)
38. Kansas G. S.: Selectins and their ligands: current concepts and controversies. Blood, 1996;88:3259-3287 (Pubitemid 26365560)
39. Kasprzyk M., Dyszkiewicz W., Piwkowski C., Ga̧siorowski L., Kaczmarek E.: Prognostic value of DNA ploidy: 5-year follow-up of patients with resectable squamous cell carcinoma (SCC) of the lung. Lung cancer, 2006;51:201-206 (Pubitemid 43144363)
40. Kawai T., Suzuki M., Kase K., Ozeki Y.: Expression of carbohydrate antigens in human pulmonary adenocarcinoma. Cancer, 1993;72:1581-1587 (Pubitemid 23249282)
41. Kelly M. P., Lee F. T., Smyth F. E., Brechbiel M. W., Scott A. M.: Enhanced efficacy of 90Y-radiolabaled anti-Lewis Y humanized monoclonal antibody hu3S193 and Paclitaxel combined-modality radioimmunotherapy in breast cancer model. J. Nucl. Med., 2006;47:716-725 (Pubitemid 46768474)
42. Kim M. J., Kim H. S., Song K. S., Noh S. H., Kim H., Paik Y. K., Kim H. O.: Altered expression of Lewis antigen on tissue and erythrocytes in gastric cancer patients. Yonsei Med. J., 2002;43:427-434 (Pubitemid 35012387)
43. Kishimoto T., Ishikura H., Kimura C., Takahashi T., Kato H., Yoshiki T.: Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis (a) antigen. Int. J. Cancer, 1996;69:290-294 (Pubitemid 26298293)
44. Klinger M., Farhan H., Just H., Drobny H., Himmler G., Loibner H., Mudde G. C., Freissmuth M., Sexl V.: Antibodies directed against Lewis-Y antigen inhibit signaling of Lewis-Y modifed ErbB receptors. Cancer Res., 2004;64:1087-1093 (Pubitemid 38176914)
45. Kłopocki A. G., Laskowska A., Antoniewicz-Papis J., Duk M., Lisowska E., Ugorski M.: Role of sialosyl Lewisa in adhesion of colon cancer cells. The antisense RNA approach. Eur. J. Biochem., 1998;253:309-318
46. Kobata A., Amano J.: Altered glycosylation of proteins produced by malignant cells, and application for the diagnosis and immunotherapy of tumours. Immunol. Cell Biol., 2005;83:429-439 (Pubitemid 41044621)
47. Koda Y., Soejima M., Kimura H.: Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA. J. Biol. Chem., 1997;272:7501-7505 (Pubitemid 27166464)
48. Koda Y., Soejima M., Wang B., Kimura H.: Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2). Eur. J. Biochem., 1997;246:750-755 (Pubitemid 27252919)
49. Koga H., Naito S., Nakashima M., Hasegawa S., Watanabe T., Kumazawa J.: A fow cytometric analysis of the expression of adhesion molecules on human renal cell carcinoma cells with different metastatic potentials. Eur. Urol., 1997;31:86-91 (Pubitemid 27058110)
50. Koike T., Kimura N., Miyazaki K., Yabuta T., Kumamoto K., Takenoshita S., Chen J., Kobayashi M., Hosokawa M., Taniguchi A., Kojima T., Ishida N., Kawakita M., Yamamoto H., Takematsu H., Suzuki A., Kozutsumi Y., Kannagi R.: Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc. Natl. Acad. Sci. USA, 2004;101:8132-8137 (Pubitemid 38698066)
51. Konety B. R.: Molecular markers in bladder cancer: a critical appraisal. Urol. Oncol., 2006;24:326-337 (Pubitemid 43963409)
52. Kurebayashi J., Nomura T., Hirono M., Okubo S., Udagawa K., Shiiki S., Ikeda M., Nakashima K., Tanaka K., Sonoo H.: Combined measurement of serum sialyl Lewis X with serum CA15-3 in breast cancer patients. Jpn. J. Clin. Oncol., 2006;36:150-153
53. Labarrière N., Piau J. P., Otry C., Denis M., Lustenberger P., Meflah K., Le Pendu J.: H blood group antigen carried by CD44V modulates tumorigenicity of rat colon carcinoma cells. Cancer Res., 1994;54:6275-6281 (Pubitemid 24378665)
54. Madjd Z., Parsons T., Watson N. F., Spendlove I., Ellis I., Durrant L. G.: High expression of Lewisy/b antigens is associated with decreased survival in lymph node negative breast carcinoma. Breast Cancer Res., 2005;7:R780-R787
55. Magnani J. L.: The discovery, biology, and drug development of sialyl Lea and sialyl Lex. Arch. Biochem. Biophys., 2004;426:122-131 (Pubitemid 38684162)
56. Mariano A., Di Carlo A., Santonastaso C., Oliva A., D'Armiento M., Macchia V.: Expression of Lewis carbohydrate antigens and chromogranin A in human prostatic cancer. Int. J. Oncol., 2000;17:167-171
57. Martín-Statué M., Marrugat R., Cancelas J. A., Blanco J.: Enhanced expression of α (1, 3)-fucosyltransferase genes correlates with E-selectinmediated adhesion and metastatic potential of human lung adenocarcinoma cells. Cancer Res., 1998;58:1544-1550 (Pubitemid 28193622)
58. Mas E., Pasqualini E., Caillol N., El Battari A., Crotte C., Lombardo D., Sadoulet M. O.: Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines. Glycobiology, 1998;8:605-613 (Pubitemid 28270582)
59. Matsui T., Kojima H., Suzuki H., Hamajima H., Nakazato H., Ito K., Nakao A., Sakamoto J.: Sialyl Lewisa expression as a predictor of the prognosis of colon carcinoma patients in a prospective randomized clinical trial. Jpn. J. Clinic. Oncol., 2004;34:588-593 (Pubitemid 40662713)
60. Mehdi S. A., Tatum A. H., Newman N. B., Imperato A., Daucher J., Kohman L. J., Graziano S. L.: Prognostic significance of Lewis y antigen in resected stage I and II non-small cell lung cancer. Chest, 1998;114:1309-1315 (Pubitemid 28527404)
61. Miyake M., Taki T., Hitomi S., Hakomori S.: Correlation of expression of H/Le (y)/Le (b) antigens with survival in patients with carcinoma of the lung. N. Eng. J. Med., 1992;327:14-18
62. x predict multilevel N2 disease in non-small-cell lung cancer. Ann. Surg. Oncol., 2006;13:1010-1018
63. Narita T., Funahashi H., Satoh Y., Watanabe T., Sakamoto J., Takagi H.: Association of expression of blood group-related carbohydrate antigens with prognosis in breast cancer. Cancer, 1993;71:3044-3053 (Pubitemid 23145537)
64. Nishihara S., Hiraga T., Ikehara Y., Kudo T., Iwasaki H., Morozumi K., Akamatsu S., Tachikawa T., Narimatsu H.: Molecular mechanisms of expression of Lewis b antigen and other Type I Lewis antigens in human colorectal cancer. Glycobiology, 1999;6:607-616 (Pubitemid 29250928)
65. Numahata K., Satoh M., Handa K., Saito S., Ohyama C., Ito A., Takahashi T., Hoshi S., Orikasa S., Hakomori S.: Sialosyl-Lex expression defines invasive and metastatic properties of bladder carcinoma. Cancer, 2002;94:673-685 (Pubitemid 34132295)
66. Ogawa J., Inoue H., Koide S.: Expression of α-1, 3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer. Cancer Res., 1996;56:325-329 (Pubitemid 26026361)
67. Ogawa J., Sano A., Inoue H., Koide S.: Expression of Lewis-related antigen and prognosis in stage I non-small cell lung cancer. Ann. Thorac. Surg., 1995;59:412-415
68. Ohyama C., Tsuboi S., Fukuda M.: Dual roles of sialyl Lewis X oligosaccharides in tumor metastasis and rejection by natural killer cells. EMBO J., 1999;18:1516-1525 (Pubitemid 29127065)
69. Okada Y., Jin-no K., Ikeda H., Sakai N., Sotozono M., Yonei T., Nakanishi S., Moriwaki S., Tsuji T.: Changes in the expression of sialyl-Lewisx, a hepatic necroinflammation-associated carbohydrate neoantigen, in human hepatocellular carcinomas. Cancer, 1994;73:1811-1816
70. Olding L. B., Thurin J., Svalander C., Koprowski H.: Expression of gastrointestinal carcinoma-associated antigen (GICA) detected in human fetal tissues by monoclonal antibody NS-19-9. Int. J. Cancer, 1984;34:187-192 (Pubitemid 14053139)
71. Orczyk-Pawiłowicz M.: Znaczenie fukozylacji glikokoniugatów w zdrowiu i chorobie. Post. Hig. Med. Dośw., 2007;61:240-252
72. Ordōñez N. G.: The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study. Hum. Pathol., 2004;35:697-710 (Pubitemid 38881080)
73. Peracaula R., Tabarés G., López-Ferrer A., Brossmer R., de Bolós C., de Llorens R.: Role of sialyltransferases involved in the biosynthesis of Lewis antigens in human pancreatic tumour cells. Glycoconj. J., 2005;22:135-144 (Pubitemid 41160332)
74. Petretti T., Kemner W., Schulze B., Schlag M.: Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases. Gut, 2000;46:359-366 (Pubitemid 30313387)
75. Powlesland A. S., Hitchen P. G., Parry S., Graham S. A., Barrio M. M., Elola M. T., Mordoh J., Dell A., Drickamer K., Taylor M. E.: Targeted glycoproteomic identification of cancer cell glycosylation. Glycobiology, 2009;19:899-909
76. Serpa J., Mesquita P., Mendes N., Oliveira C., Almeida R., Santos-Silva F., Reis C. A., Le Pendu J., David L.: Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation. Cancer Lett., 2006;242:191-197 (Pubitemid 44485309)
77. Sheinfeld J., Reuter V. E., Sarkis A. S., Cordon-Cardo C.: Blood group antigens in normal and neoplastic urothelium. J. Cell. Biochem. Suppl., 1992;16 I: 50-55 (Pubitemid 23109028)
78. Shitara K., Hanai N., Yoshida H.: Distribution of lung adenocarcinoma-associated antigens in human tissues and sera defned by monoclonal antibodies KM-52 and KM-93. Cancer Res., 1987;47:1267-1272 (Pubitemid 17023193)
79. Smolarek D., Krop-Wa̧torek A., Waśniowska K., Czerwiński M.: Molekularne podstawy układu grupowego ABO. Post. Hig. Med. Dośw., 2008;62:4-17
80. Soejima M., Koda Y.: Molecular mechanisms of Lewis antigen expression. Legal Medicine, 2005;7:266-269 (Pubitemid 40828868)
81. St Hill C. A., Farooqui M., Mitcheltree G., Gulbahce H. E., Jessurun J., Cao Q., Walcheck B.: The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2β1, 6-N-acetylglucosaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas. BMC Cancer. 2009;9:79
82. Tei K., Kawakami-Kimura N., Taguchi O., Kumamoto K., Higashiyama S., Taniguchi N., Toda K., Kawata R., Hisa Y., Kannagi R.: Roles of cell adhesion molecules in tumor angiogenesis induced by cotransplantation of cancer and endothelial cells to nude rats. Cancer Res., 2002;62:6289-6296 (Pubitemid 35244483)
83. Torrado J., Plummer M., Vivas J., Garay J., Lopez G., Peraza S., Carillo E., Oliver W., Muñoz N.: Lewis antigen alterations in a population at high risk of stomach cancer. Cancer Epidemiol. Biomarkers Prev., 2000;9:671-674 (Pubitemid 30482697)
84. Tozawa K., Okamoto T., Kawai N., Hashimoto Y., Hayashi Y., Kohri K.: Positive correlation between sialyl Lewis X expression and pathologic findings in renal cell carcinoma. Kidney Int., 2005;67:1391-1396 (Pubitemid 40463115)
85. Ugorski M., Kłopocki A. G.: Udział antygenów sjalo-Lea i sjaloLex w adhezji i progresywnym wzroście nowotworowym. Post. Hig. Med. Dośw., 1996;50:209-231
86. Ugorski M., Laskowska A.: Sialyl Lewisa: a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells. Acta Biochim. Pol., 2002;49:303-311 (Pubitemid 135686776)
87. Walz G., Aruffo A., Kolanus W., Bevilacqua M., Seed B.: Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science, 1990;250:1132-1135 (Pubitemid 120031821)
88. Yago K., Zenita K., Ginya H., Sawada M., Ohmori K., Okuma M., Kannagi R., Lowe J. B.: Expression of α-(1, 3)-fucosyltransferases which synthesize sialyl Lex and sialyl Lea, the carbohydrate ligands for E-and P-selectins, in human malignant cell lines. Cancer Res., 1993;53:5559-5565 (Pubitemid 23342184)
89. Yazawa S., Nishimura T., Ide M., Asao T., Okamura A., Tanaka S., Takai I., Yagihashi Y., Saniabadi A. R., Kochibe N.: Tumor-related expression of α;1, 2fucosylated antigens on colorectal carcinoma cells and its suppression by cell-mediated priming using sugar acceptors for α1, 2fucosyltransferase. Glycobiology, 2002;12:545-553
90. Yu Q., Toole B. P., Stamenkovic I.: Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J. Exp. Med., 1997;186:1985-1996 (Pubitemid 28013682)
91. Yuan K., Kucik D., Singh R. K., Listinsky C. M., Listinsky J. J., Siegal G. P.: Alterations in human breast cancer adhesion-motility in response to changes in cell surface glycoproteins displaying alpha-L-fucose moieties. Int. J. Oncol., 2008;32:797-807 (Pubitemid 351780590)
92. Zhang Z., Sun P., Liu J., Fu L., Yan J., Liu Y., Yu L., Wang X., Yan Q.: Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth. Biochim. Biophys. Acta, 2008;1783:287-296