메뉴 건너뛰기




Volumn 10, Issue 5, 2010, Pages 559-563

Screening Europe 2010: An update about the latest technologies and applications in high-throughput screening

Author keywords

cell based assays; cytotoxicity; fragment based screening; high throughput screening; label free screening; microfluidics

Indexed keywords

PENICILLIN G; STREPTOMYCIN; VANILLOID RECEPTOR 1; DRUG;

EID: 77954735319     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.10.42     Document Type: Conference Paper
Times cited : (4)

References (32)
  • 2
    • 67650070045 scopus 로고    scopus 로고
    • Multi-parameter phenotypic profiling: Using cellular effects to characterize small-molecule compounds
    • Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat. Rev. Drug Discov. 8(7), 567-578 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , Issue.7 , pp. 567-578
    • Feng, Y.1    Mitchison, T.J.2    Bender, A.3    Young, D.W.4    Tallarico, J.A.5
  • 3
    • 77954715762 scopus 로고    scopus 로고
    • Primary, iPS and stem cells: Emerging tools for HTS?
    • Presented at: Barcelona, Spain, 11-12 February
    • Eglen RM. Primary, iPS and stem cells: emerging tools for HTS? Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Eglen, R.M.1
  • 4
    • 49449104663 scopus 로고    scopus 로고
    • An overview of drug screening using primary and embryonic stem cells
    • Eglen RM, Gilchrist A, Reisine T. An overview of drug screening using primary and embryonic stem cells. Comb. Chem. High Throughput Screen. 11(7), 566-572 (2008).
    • (2008) Comb. Chem. High Throughput Screen. , vol.11 , Issue.7 , pp. 566-572
    • Eglen, R.M.1    Gilchrist, A.2    Reisine, T.3
  • 5
    • 77954719828 scopus 로고    scopus 로고
    • Cell based assay development -It all starts with the cell
    • Presented at: Barcelona, Spain, 11-12 February
    • Cawkill D. Cell based assay development -it all starts with the cell. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Cawkill, D.1
  • 6
    • 77954699925 scopus 로고    scopus 로고
    • High-throughput screening in human embryonic stem cells for drug discovery
    • Presented at: Barcelona, Spain, 11-12 February
    • Desbordes SC. High-throughput screening in human embryonic stem cells for drug discovery. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Desbordes, S.C.1
  • 7
    • 44349152907 scopus 로고    scopus 로고
    • High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
    • Desbordes SC, Placantonakis DG, Ciro A et al. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2(6), 602-612 (2008).
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 602-612
    • Desbordes, S.C.1    Placantonakis, D.G.2    Ciro, A.3
  • 8
    • 77954746499 scopus 로고    scopus 로고
    • SciWIFTER applications for in vitro cellular screening
    • Presented at: Barcelona, Spain, 11-12 February
    • Ivanov I. sciWIFTER applications for in vitro cellular screening. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Ivanov, I.1
  • 9
    • 77954702041 scopus 로고    scopus 로고
    • Technology spotlight: Illuminating your pathway to discovery: Cell based assays for efficacy and safety profiling
    • Presented at: Barcelona, Spain, 11-12 February
    • Augustin M. Technology spotlight: illuminating your pathway to discovery: cell based assays for efficacy and safety profiling. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Augustin, M.1
  • 10
    • 77954727082 scopus 로고    scopus 로고
    • Indirect inhibition assays and droplet-based microfluidics
    • Presented at: Barcelona, Spain, 11-12 February
    • Merten CA. Indirect inhibition assays and droplet-based microfluidics. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Merten, C.A.1
  • 13
    • 77954717445 scopus 로고    scopus 로고
    • Validation of a zebrafish automated screening platform
    • Presented at: Barcelona, Spain, 11-12 February
    • Callol-Massot C. Validation of a zebrafish automated screening platform. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Callol-Massot, C.1
  • 14
    • 77954698005 scopus 로고    scopus 로고
    • Using label-free technologies to improve screening and hit validation
    • Presented at: Barcelona, Spain, 11-12 February
    • Sundberg F. Using label-free technologies to improve screening and hit validation. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Sundberg, F.1
  • 15
    • 77954717444 scopus 로고    scopus 로고
    • Rapid, label-free screening and affinity determination of fragments binding specifically to drug targets
    • Presented at: Barcelona, Spain, 11-12 February
    • Bomke J. Rapid, label-free screening and affinity determination of fragments binding specifically to drug targets. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Bomke, J.1
  • 16
    • 77954711726 scopus 로고    scopus 로고
    • Challenges and successes in fragment-based lead generation: Increasing impact across drug discovery
    • Presented at: Barcelona, Spain, 11-12 February
    • Albert J. Challenges and successes in fragment-based lead generation: increasing impact across drug discovery. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Albert, J.1
  • 18
    • 77954744799 scopus 로고    scopus 로고
    • Screening for selectivity
    • Presented at: Barcelona, Spain, 11-12 February
    • Uitdehaag J. Screening for selectivity. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Uitdehaag, J.1
  • 19
    • 36148943501 scopus 로고    scopus 로고
    • Gini coefficient: A new way to express selectivity of kinase inhibitors against a family of kinases
    • Graczyk PP. Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases. J. Med. Chem. 50(23), 5773-5779 (2007).
    • (2007) J. Med. Chem. , vol.50 , Issue.23 , pp. 5773-5779
    • Graczyk, P.P.1
  • 20
    • 38049018155 scopus 로고    scopus 로고
    • A quantitative analysis of kinase inhibitor selectivity
    • Karaman MW, Herrgard S, Treiber DK et al. A quantitative analysis of kinase inhibitor selectivity. Nat. Biotechnol. 26(1), 127-132 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , Issue.1 , pp. 127-132
    • Karaman, M.W.1    Herrgard, S.2    Treiber, D.K.3
  • 21
    • 66449111715 scopus 로고    scopus 로고
    • B-arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice
    • Walters RW, Shukla AK, Kovacs JJ et al. b-arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. J. Clin. Invest. 119(5), 1312-1321 (2009).
    • (2009) J. Clin. Invest. , vol.119 , Issue.5 , pp. 1312-1321
    • Walters, R.W.1    Shukla, A.K.2    Kovacs, J.J.3
  • 22
    • 22844439234 scopus 로고    scopus 로고
    • (D)-b-hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G
    • Taggart AK, Kero J, Gan X et al. (D)-b-hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J. Biol. Chem. 280(29), 26649-26652 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.29 , pp. 26649-26652
    • Taggart, A.K.1    Kero, J.2    Gan, X.3
  • 23
    • 77954718496 scopus 로고    scopus 로고
    • What are the right assays to select? Studies with receptors for free fatty acids
    • Presented at: Barcelona, Spain, 11-12 February
    • Milligan SE. What are the right assays to select? Studies with receptors for free fatty acids. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Milligan, S.E.1
  • 24
    • 43149111583 scopus 로고    scopus 로고
    • Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms
    • Clausell-Tormos J, Lieber D, Baret JC et al. Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms. Chem. Biol. 15(5), 427-437 (2008).
    • (2008) Chem. Biol. , vol.15 , Issue.5 , pp. 427-437
    • Clausell-Tormos, J.1    Lieber, D.2    Baret, J.C.3
  • 25
    • 77954695348 scopus 로고    scopus 로고
    • Multiplex target screening by high throughput flow cytometry
    • Presented at: Barcelona, Spain, 11-12 February
    • Sklar L. Multiplex target screening by high throughput flow cytometry. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Sklar, L.1
  • 26
    • 77949552684 scopus 로고    scopus 로고
    • High-throughput screening of enzymes by retroviral display using droplet-based microfluidics
    • Granieri L, Baret J-C, Griffiths AD, Merten CA. High-throughput screening of enzymes by retroviral display using droplet-based microfluidics. Chem. Biol. 17(3), 229-235 (2010).
    • (2010) Chem. Biol. , vol.17 , Issue.3 , pp. 229-235
    • Granieri, L.1    Baret, J.-C.2    Griffiths, A.D.3    Merten, C.A.4
  • 27
    • 77951899852 scopus 로고    scopus 로고
    • An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries
    • DOI: 10.1039/b921754a (Epub ahead of print)
    • Clausell-Tormos J, Griffiths AD, Merten CA. An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries. Lab. Chip DOI: 10.1039/b921754a (2010) (Epub ahead of print).
    • (2010) Lab. Chip
    • Clausell-Tormos, J.1    Griffiths, A.D.2    Merten, C.A.3
  • 28
    • 77954698364 scopus 로고    scopus 로고
    • Total assay assembly enabled with acoustic droplet ejection
    • Presented at: Barcelona, Spain, 11-12 February
    • Ellson R. Total assay assembly enabled with acoustic droplet ejection. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Ellson, R.1
  • 29
    • 77954730285 scopus 로고    scopus 로고
    • I-doT (immediate drop on demand technology) fast and direct sample handling for MWPs
    • Presented at: Barcelona, Spain, 11-12 February
    • Brode T. i-doT (immediate drop on demand technology) fast and direct sample handling for MWPs. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Brode, T.1
  • 30
    • 77954741336 scopus 로고    scopus 로고
    • Thermo-TRP ion channels as drug targets
    • Presented at: Barcelona, Spain, 11-12 February
    • McNaughton P. Thermo-TRP ion channels as drug targets. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • McNaughton, P.1
  • 31
    • 77954728634 scopus 로고    scopus 로고
    • A high-throughput approach for identification of candidate general anesthetics
    • Presented at: Barcelona, Spain, 11-12 February
    • Lea W. A high-throughput approach for identification of candidate general anesthetics. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
    • (2010) 7th Annual Screening Europe Conference
    • Lea, W.1
  • 32
    • 69949157213 scopus 로고    scopus 로고
    • A unitary anesthetic binding site at high resolution
    • Vedula LS, Brannigan G, Economou NJ et al. A unitary anesthetic binding site at high resolution. J. Biol. Chem. 284(36), 24176-24184 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.36 , pp. 24176-24184
    • Vedula, L.S.1    Brannigan, G.2    Economou, N.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.