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1
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0038387389
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Hit and lead generation: Beyond high-throughput screening
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Bleicher, K.H.1
Böhm, H.J.2
Müller, K.3
Alanine, A.I.4
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2
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67650070045
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Multi-parameter phenotypic profiling: Using cellular effects to characterize small-molecule compounds
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Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat. Rev. Drug Discov. 8(7), 567-578 (2009).
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Feng, Y.1
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Young, D.W.4
Tallarico, J.A.5
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3
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77954715762
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Primary, iPS and stem cells: Emerging tools for HTS?
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Presented at: Barcelona, Spain, 11-12 February
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Eglen RM. Primary, iPS and stem cells: emerging tools for HTS? Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Eglen, R.M.1
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5
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77954719828
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Cell based assay development -It all starts with the cell
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Presented at: Barcelona, Spain, 11-12 February
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Cawkill D. Cell based assay development -it all starts with the cell. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Cawkill, D.1
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6
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77954699925
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High-throughput screening in human embryonic stem cells for drug discovery
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Presented at: Barcelona, Spain, 11-12 February
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Desbordes SC. High-throughput screening in human embryonic stem cells for drug discovery. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Desbordes, S.C.1
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7
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44349152907
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High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
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Desbordes SC, Placantonakis DG, Ciro A et al. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2(6), 602-612 (2008).
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Cell Stem Cell
, vol.2
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Desbordes, S.C.1
Placantonakis, D.G.2
Ciro, A.3
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8
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77954746499
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SciWIFTER applications for in vitro cellular screening
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Presented at: Barcelona, Spain, 11-12 February
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Ivanov I. sciWIFTER applications for in vitro cellular screening. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Ivanov, I.1
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9
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77954702041
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Technology spotlight: Illuminating your pathway to discovery: Cell based assays for efficacy and safety profiling
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Presented at: Barcelona, Spain, 11-12 February
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Augustin M. Technology spotlight: illuminating your pathway to discovery: cell based assays for efficacy and safety profiling. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Augustin, M.1
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10
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77954727082
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Indirect inhibition assays and droplet-based microfluidics
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Presented at: Barcelona, Spain, 11-12 February
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Merten CA. Indirect inhibition assays and droplet-based microfluidics. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Merten, C.A.1
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11
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67249131907
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A competition-based assay for the screening of species-specific antibiotics
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Granieri L, Miller OJ, Griffiths AD, Merten CA. A competition-based assay for the screening of species-specific antibiotics. J. Antimicrob. Chemother. 64(1), 62-68 (2009).
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(2009)
J. Antimicrob. Chemother.
, vol.64
, Issue.1
, pp. 62-68
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Granieri, L.1
Miller, O.J.2
Griffiths, A.D.3
Merten, C.A.4
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13
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77954717445
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Validation of a zebrafish automated screening platform
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Presented at: Barcelona, Spain, 11-12 February
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Callol-Massot C. Validation of a zebrafish automated screening platform. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Callol-Massot, C.1
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14
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77954698005
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Using label-free technologies to improve screening and hit validation
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Presented at: Barcelona, Spain, 11-12 February
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Sundberg F. Using label-free technologies to improve screening and hit validation. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Sundberg, F.1
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15
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77954717444
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Rapid, label-free screening and affinity determination of fragments binding specifically to drug targets
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Presented at: Barcelona, Spain, 11-12 February
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Bomke J. Rapid, label-free screening and affinity determination of fragments binding specifically to drug targets. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Bomke, J.1
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16
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77954711726
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Challenges and successes in fragment-based lead generation: Increasing impact across drug discovery
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Presented at: Barcelona, Spain, 11-12 February
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Albert J. Challenges and successes in fragment-based lead generation: increasing impact across drug discovery. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Albert, J.1
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17
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0033576601
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The design of leadlike combinatorial libraries
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Teague, S.J.1
Davis, A.M.2
Leeson, P.D.3
Oprea, T.4
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18
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77954744799
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Screening for selectivity
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Presented at: Barcelona, Spain, 11-12 February
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Uitdehaag J. Screening for selectivity. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Uitdehaag, J.1
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19
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36148943501
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Gini coefficient: A new way to express selectivity of kinase inhibitors against a family of kinases
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Graczyk PP. Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases. J. Med. Chem. 50(23), 5773-5779 (2007).
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J. Med. Chem.
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Graczyk, P.P.1
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20
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38049018155
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A quantitative analysis of kinase inhibitor selectivity
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Nat. Biotechnol.
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Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
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21
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66449111715
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B-arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice
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Walters RW, Shukla AK, Kovacs JJ et al. b-arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. J. Clin. Invest. 119(5), 1312-1321 (2009).
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J. Clin. Invest.
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Walters, R.W.1
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22
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(D)-b-hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G
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Taggart, A.K.1
Kero, J.2
Gan, X.3
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23
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77954718496
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What are the right assays to select? Studies with receptors for free fatty acids
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Presented at: Barcelona, Spain, 11-12 February
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Milligan SE. What are the right assays to select? Studies with receptors for free fatty acids. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Milligan, S.E.1
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24
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43149111583
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Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms
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Clausell-Tormos J, Lieber D, Baret JC et al. Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms. Chem. Biol. 15(5), 427-437 (2008).
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Chem. Biol.
, vol.15
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, pp. 427-437
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Clausell-Tormos, J.1
Lieber, D.2
Baret, J.C.3
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25
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77954695348
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Multiplex target screening by high throughput flow cytometry
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Presented at: Barcelona, Spain, 11-12 February
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Sklar L. Multiplex target screening by high throughput flow cytometry. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Sklar, L.1
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26
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77949552684
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High-throughput screening of enzymes by retroviral display using droplet-based microfluidics
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Granieri L, Baret J-C, Griffiths AD, Merten CA. High-throughput screening of enzymes by retroviral display using droplet-based microfluidics. Chem. Biol. 17(3), 229-235 (2010).
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Chem. Biol.
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Granieri, L.1
Baret, J.-C.2
Griffiths, A.D.3
Merten, C.A.4
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27
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77951899852
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An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries
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DOI: 10.1039/b921754a (Epub ahead of print)
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Clausell-Tormos J, Griffiths AD, Merten CA. An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries. Lab. Chip DOI: 10.1039/b921754a (2010) (Epub ahead of print).
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(2010)
Lab. Chip
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Clausell-Tormos, J.1
Griffiths, A.D.2
Merten, C.A.3
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28
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77954698364
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Total assay assembly enabled with acoustic droplet ejection
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Presented at: Barcelona, Spain, 11-12 February
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Ellson R. Total assay assembly enabled with acoustic droplet ejection. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Ellson, R.1
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29
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77954730285
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I-doT (immediate drop on demand technology) fast and direct sample handling for MWPs
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Presented at: Barcelona, Spain, 11-12 February
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Brode T. i-doT (immediate drop on demand technology) fast and direct sample handling for MWPs. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Brode, T.1
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30
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77954741336
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Thermo-TRP ion channels as drug targets
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Presented at: Barcelona, Spain, 11-12 February
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McNaughton P. Thermo-TRP ion channels as drug targets. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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McNaughton, P.1
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31
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77954728634
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A high-throughput approach for identification of candidate general anesthetics
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Presented at: Barcelona, Spain, 11-12 February
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Lea W. A high-throughput approach for identification of candidate general anesthetics. Presented at: 7th Annual Screening Europe Conference. Barcelona, Spain, 11-12 February 2010.
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(2010)
7th Annual Screening Europe Conference
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Lea, W.1
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32
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69949157213
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A unitary anesthetic binding site at high resolution
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J. Biol. Chem.
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Vedula, L.S.1
Brannigan, G.2
Economou, N.J.3
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