Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines

Molecular Diversity

Volumn 14, Issue 2, 2010, Pages 307-320

  Zohrabi Kalantari, Vida ^a   Heidler, Philipp ^a   Kaiser, Marcel ^b   Brun, Reto ^b   Kamper, Christoph ^c   Link, Andreas ^c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Anti plasmodial activity; Anti trypanosomal activity; Modified nucleosides; Polymer bound reagents

Indexed keywords

5' AMINO 5' DEOXY N 6 (4 METHOXYBENZYL)ADENOSINE; 5' AMINO 5' DEOXY N 6 [2 (3,4 DIMETHOXYPHENYL)ETHYL]ADENOSINE; 5' AMINO 5' DEOXYADENOSINE; 5' AMINO N 6 (CYCLOPROPYLMETHYL) 5' DEOXY ADENOSINE; 5' DEOXY 5' [(3,3 DIMETHYL)ACRYLAMIDO] N 6 (4 METHOXYBENZYL)ADENOSINE; 5' DEOXY 5' [(3,4 DIETHOXY)BENZAMIDO] N 6 (4 METHOXYBENZYL)ADENOSINE; 5' DEOXY 5' [(3,5 DICHLORO)BENZAMIDO] N 6 (4 METHOXYBENZYL)ADENOSINE; 5' DEOXY 5' [(4 ETHOXY)BENZAMIDO] N 6 (4 METHOXYBENZYL)ADENOSINE; 5' DEOXY N 6 (4 METHOXYBENZYL) 5' PHTHALIMIDO 1 YL ADENOSINE; 5' DEOXY N 6 (4 METHOXYBENZYL) 5' [(1 PHENYL)CYCLOPENTYLAMIDO] ADENOSINE; 5' DEOXY N 6 (4 METHOXYBENZYL) 5' [(3 TRIFLUOROMETHOXY)BENZAMIDO] ADENOSINE; 5' DEOXY N 6 (4 METHOXYBENZYL) 5' [(4 PHENYL)BUTANAMIDO]ADENOSINE; 5' DEOXY N 6 [2 (3,4 DIMETHOXYPHENYL)ETHYL] 5' PHTHALIMIDO 1 YL ADENOSINE; 5' [(4 ACETYLAMINO)BENZAMIDO] 5' DEOXY N 6 (4 METHOXYBENZYL)ADENOSINE; 5' [(4 ACETYLAMINO)BENZAMIDO] N 6 (CYCLOPROPYLMETHYL) 5' DEOXY ADENOSINE; ADENOSINE DERIVATIVE; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; N 6 (4 METHOXYBENZYL)ADENOSINE; N 6 (C YCLOPROPYLMETHYL) 5' DEOXY 5' [(4 ETHOXY)BENZAMIDO]ADENOSINE; N 6 (CYCLOPROPYLMETHYL) 5' DEOXY 5' PHTHALIMIDO 1 YL ADENOSINE; N 6 (CYCLOPROPYLMETHYL) 5' DEOXY 5' [(1 PHENYL)CYCLOPENTYLAMIDO]ADENOSINE; N 6 (CYCLOPROPYLMETHYL) 5' DEOXY 5' [(3 INDOLYL)ACETAMIDO]ADENOSINE; N 6 (CYCLOPROPYLMETHYL) 5' DEOXY 5' [(3,3 DIMETHYL)ACRYLAMIDO]ADENOSINE; N 6 (CYCLOPROPYLMETHYL) 5' DEOXY 5' [(3,4 DIETHOXY)BENZAMIDO]ADENOSINE; N 6 (CYCLOPROPYLMETHYL) 5' DEOXY 5' [(3,5 DICHLORO)BENZAMIDO]ADENOSINE; N 6 (CYCLOPROPYLMETHYL) 5' DEOXY 5' [(4 PHENYL)BUTANAMIDO]ADENOSINE; N 6 (CYCLOPROPYLMETHYL)ADENOSINE; N 6 [2 (3,4 DIMETHOXYPHENYL)ETHYL]ADENOSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 5'-AMINO-5'-DEOXYADENOSINE; ADENOSINE; DEOXYADENOSINE DERIVATIVE;

ACYLATION; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ISOMER; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; IC 50; METABOLISM; SYNTHESIS;

ACYLATION; ADENOSINE; ANTIMALARIALS; DEOXYADENOSINES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 77954673807     PISSN: 13811991     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11030-009-9176-2     Document Type: Article

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