-
1
-
-
23944452267
-
Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites
-
Baliani A, Bueno GJ, Stewart ML, Yardley V, Brun R, Barrett MP, and Gilbert IH (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites. J Med Chem 48:5570-5579.
-
(2005)
J Med Chem
, vol.48
, pp. 5570-5579
-
-
Baliani, A.1
Bueno, G.J.2
Stewart, M.L.3
Yardley, V.4
Brun, R.5
Barrett, M.P.6
Gilbert, I.H.7
-
2
-
-
0033119815
-
The biochemical basis of arsenical-diamidine cross-resistance in African trypanosomes
-
Barrett MP and Fairlamb AH (1999) The biochemical basis of arsenical-diamidine cross-resistance in African trypanosomes. Parasitol Today 15:136-140.
-
(1999)
Parasitol Today
, vol.15
, pp. 136-140
-
-
Barrett, M.P.1
Fairlamb, A.H.2
-
3
-
-
0002957502
-
Purine and pyrimidine metabolism
-
Marr JJ and Muller M eds pp, Academic Press, London
-
Berens RL, Krug EC, and Marr JJ (1995) Purine and pyrimidine metabolism, in Biochemistry and Molecular Biology of Parasites (Marr JJ and Muller M eds) pp 89-117, Academic Press, London.
-
(1995)
Biochemistry and Molecular Biology of Parasites
, pp. 89-117
-
-
Berens, R.L.1
Krug, E.C.2
Marr, J.J.3
-
4
-
-
0018601361
-
Cultivation and in vitro cloning of procyclic culture forms in Trypanosoma brucei in a semi-defined medium
-
Brun R and Schönenberger M (1979) Cultivation and in vitro cloning of procyclic culture forms in Trypanosoma brucei in a semi-defined medium. Acta Trop 36:289-292.
-
(1979)
Acta Trop
, vol.36
, pp. 289-292
-
-
Brun, R.1
Schönenberger, M.2
-
5
-
-
0037593443
-
Cloning, heterologous expression and in situ characterization of the first high affinity nucleobase transporter from a protozoan
-
Burchmore R, Wallace LJM, Candlish D, Al-Salabi MI, Beal P, Barrett MP, Baldwin SA, and de Koning HP (2003) Cloning, heterologous expression and in situ characterization of the first high affinity nucleobase transporter from a protozoan. J Biol Chem 278:23502-23507.
-
(2003)
J Biol Chem
, vol.278
, pp. 23502-23507
-
-
Burchmore, R.1
Wallace, L.J.M.2
Candlish, D.3
Al-Salabi, M.I.4
Beal, P.5
Barrett, M.P.6
Baldwin, S.A.7
de Koning, H.P.8
-
6
-
-
0027500261
-
Arsenical-resistant trypanosomes lack an unusual adenosine transporter
-
Carter NS and Fairlamb AH (1993) Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature (Lond) 361:173-176.
-
(1993)
Nature (Lond)
, vol.361
, pp. 173-176
-
-
Carter, N.S.1
Fairlamb, A.H.2
-
7
-
-
0037090528
-
Life without transcriptional control? From fly to man and back again
-
Clayton CE (2002) Life without transcriptional control? From fly to man and back again. EMBO (Eur Mol Biol Organ) J 21:1881-1888.
-
(2002)
EMBO (Eur Mol Biol Organ) J
, vol.21
, pp. 1881-1888
-
-
Clayton, C.E.1
-
8
-
-
0035339852
-
Transporters in African trypanosomes: Role in drug action and resistance
-
de Koning HP (2001) Transporters in African trypanosomes: role in drug action and resistance. Int J Parasitol 31:512-522.
-
(2001)
Int J Parasitol
, vol.31
, pp. 512-522
-
-
de Koning, H.P.1
-
9
-
-
0030767791
-
Purine nucleobase transport in bloodstream forms of Trypanosoma brucei brucei is mediated by two novel transporters
-
de Koning HP and Jarvis SM (1997) Purine nucleobase transport in bloodstream forms of Trypanosoma brucei brucei is mediated by two novel transporters. Mol Biochem Parasitol 89:245-258.
-
(1997)
Mol Biochem Parasitol
, vol.89
, pp. 245-258
-
-
de Koning, H.P.1
Jarvis, S.M.2
-
10
-
-
0032732283
-
Adenosine transporters in bloodstream forms of Trypanosoma brucei brucei: Substrate recognition motifs and affinity for trypanocidal drugs
-
de Koning HP and Jarvis SM (1999) Adenosine transporters in bloodstream forms of Trypanosoma brucei brucei: substrate recognition motifs and affinity for trypanocidal drugs. Mol Pharmacol 56:1162-1170.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1162-1170
-
-
de Koning, H.P.1
Jarvis, S.M.2
-
12
-
-
0032540245
-
Characterisation of a nucleoside/proton symporter in procyclic Trypanosoma brucei brucei
-
de Koning HP, Watson CJ, and Jarvis SM (1998) Characterisation of a nucleoside/proton symporter in procyclic Trypanosoma brucei brucei. J Biol Chem 273:9486-9494.
-
(1998)
J Biol Chem
, vol.273
, pp. 9486-9494
-
-
de Koning, H.P.1
Watson, C.J.2
Jarvis, S.M.3
-
13
-
-
0033969151
-
Differential regulation of nucleoside and nucleobase transport in Crithidia fasciculata and Trypanosoma brucei in response to purine stress
-
de Koning HP, Watson CJ, Sutcliffe L, and Jarvis SM (2000) Differential regulation of nucleoside and nucleobase transport in Crithidia fasciculata and Trypanosoma brucei in response to purine stress. Mol Biochem Parasitol 106:93-107.
-
(2000)
Mol Biochem Parasitol
, vol.106
, pp. 93-107
-
-
de Koning, H.P.1
Watson, C.J.2
Sutcliffe, L.3
Jarvis, S.M.4
-
14
-
-
33847092850
-
Drugs and drug resistance in African trypanosomiasis
-
in press
-
Delespaux V and de Koning HP (2007) Drugs and drug resistance in African trypanosomiasis. Drug Resist Updat, in press.
-
(2007)
Drug Resist Updat
-
-
Delespaux, V.1
de Koning, H.P.2
-
15
-
-
23944454184
-
Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited
-
Geiser F, Lüscher A, de Koning HP, Seebeck T, and Mäser P (2005) Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited. Mol Pharmacol 68:589-595.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 589-595
-
-
Geiser, F.1
Lüscher, A.2
de Koning, H.P.3
Seebeck, T.4
Mäser, P.5
-
16
-
-
0031080037
-
Stimulated transport of adenosine, guanosine and hypoxanthine in Crithidia luciliae: Metabolic machinery in which the parasite has a distinct advantage over the host
-
Gero AM, Day RE, and Hall ST (1997) Stimulated transport of adenosine, guanosine and hypoxanthine in Crithidia luciliae: metabolic machinery in which the parasite has a distinct advantage over the host. Int J Parasitol 27:241-249.
-
(1997)
Int J Parasitol
, vol.27
, pp. 241-249
-
-
Gero, A.M.1
Day, R.E.2
Hall, S.T.3
-
17
-
-
0034143440
-
A new family of high-affinity transporters for adenine, cytosine, and purine derivatives in Arabidopsis
-
Gillissen B, Bürkle L, André B, Kühn C, Rentsch D, Brandl B, and Frommer WF (2000) A new family of high-affinity transporters for adenine, cytosine, and purine derivatives in Arabidopsis. Plant Cell 12:291-300.
-
(2000)
Plant Cell
, vol.12
, pp. 291-300
-
-
Gillissen, B.1
Bürkle, L.2
André, B.3
Kühn, C.4
Rentsch, D.5
Brandl, B.6
Frommer, W.F.7
-
18
-
-
3042655528
-
Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance
-
Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, and Sadée W (2004) Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 64:4294-4301.
-
(2004)
Cancer Res
, vol.64
, pp. 4294-4301
-
-
Huang, Y.1
Anderle, P.2
Bussey, K.J.3
Barbacioru, C.4
Shankavaram, U.5
Dai, Z.6
Reinhold, W.C.7
Papp, A.8
Weinstein, J.N.9
Sadée, W.10
-
20
-
-
13444269026
-
identification and characterization of purine nucleoside transporters from Crithidia fasciculata
-
Liu W, Arendt CS, Gessford SK, Ntaba D, Carter NS, and Ullman B (2005) identification and characterization of purine nucleoside transporters from Crithidia fasciculata. Mol Biochem Parasitol 140:1-12.
-
(2005)
Mol Biochem Parasitol
, vol.140
, pp. 1-12
-
-
Liu, W.1
Arendt, C.S.2
Gessford, S.K.3
Ntaba, D.4
Carter, N.S.5
Ullman, B.6
-
21
-
-
33847132229
-
Chemotherapeutic strategies against Trypanosoma brucei: Drug targets vs. drug targeting
-
Lüscher A, de Koning HP, and Mäser P (2007) Chemotherapeutic strategies against Trypanosoma brucei: drug targets vs. drug targeting. Curr Pharm Des 13:555-567.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 555-567
-
-
Lüscher, A.1
de Koning, H.P.2
Mäser, P.3
-
22
-
-
0037834651
-
A nucleoside transporter from Trypanosoma brucei involved in drug resistance
-
Mäser P, Sütterlin C, Kralli A, and Kaminsky R (1999) A nucleoside transporter from Trypanosoma brucei involved in drug resistance. Science (Wash DC) 285:242-244.
-
(1999)
Science (Wash DC)
, vol.285
, pp. 242-244
-
-
Mäser, P.1
Sütterlin, C.2
Kralli, A.3
Kaminsky, R.4
-
23
-
-
14744270896
-
Trypanosoma brucei: Expression of multiple purine transporters prevents the development of allopurinol resistance
-
Natto M, Wallace LJM, Candlish D, Al Salabi MI, Coutts SE, and de Koning HP (2005) Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance. Exp Parasitol 109:80-86.
-
(2005)
Exp Parasitol
, vol.109
, pp. 80-86
-
-
Natto, M.1
Wallace, L.J.M.2
Candlish, D.3
Al Salabi, M.I.4
Coutts, S.E.5
de Koning, H.P.6
-
24
-
-
11844257006
-
-
Pastor-Anglada M, Cano-Solado P, Molina-Arcas M, Lostao MP, Larráyoz I, Martínez-Picado J, and Casado FJ (2005) Virus Res 107:151-164.
-
(2005)
Virus Res
, vol.107
, pp. 151-164
-
-
Pastor-Anglada, M.1
Cano-Solado, P.2
Molina-Arcas, M.3
Lostao, M.P.4
Larráyoz, I.5
Martínez-Picado, J.6
Casado, F.J.7
-
25
-
-
0029154658
-
NTR1 encodes a high affinity oligopeptide transporter in Arabidopsis
-
Rentsch D, Laloi M, Rouhara I, Schmeltzer E, Delrot S, and Frommer WB (1995) NTR1 encodes a high affinity oligopeptide transporter in Arabidopsis. FEBS Lett 370:264-268.
-
(1995)
FEBS Lett
, vol.370
, pp. 264-268
-
-
Rentsch, D.1
Laloi, M.2
Rouhara, I.3
Schmeltzer, E.4
Delrot, S.5
Frommer, W.B.6
-
26
-
-
2942616973
-
A novel purine nucleoside transporter whose expression is up-regulated in the short-stumpy form of the Trypanosoma brucei life cycle
-
Sanchez MA, Drutman S, Van Ampting M, Matthews K, and Landfear SM (2004) A novel purine nucleoside transporter whose expression is up-regulated in the short-stumpy form of the Trypanosoma brucei life cycle. Mol Biochem Parasitol 136:265-272.
-
(2004)
Mol Biochem Parasitol
, vol.136
, pp. 265-272
-
-
Sanchez, M.A.1
Drutman, S.2
Van Ampting, M.3
Matthews, K.4
Landfear, S.M.5
-
27
-
-
0037077260
-
Six related nucleoside/nucleobase transporters from Trypanosoma brucei exhibit distinct biochemical functions
-
Sanchez MA, Tryon R, Green J, Boor I, and Landfear SM (2002) Six related nucleoside/nucleobase transporters from Trypanosoma brucei exhibit distinct biochemical functions. J Biol Chem 277:21499-21504.
-
(2002)
J Biol Chem
, vol.277
, pp. 21499-21504
-
-
Sanchez, M.A.1
Tryon, R.2
Green, J.3
Boor, I.4
Landfear, S.M.5
-
28
-
-
0033570124
-
Cloning and functional expression of a gene encoding a P1 type nucleoside transporter from Trypanosoma brucei
-
Sanchez MA, Ullman B, Landfear SM, and Carter NS (1999) Cloning and functional expression of a gene encoding a P1 type nucleoside transporter from Trypanosoma brucei. J Biol Chem 274:30244-30249.
-
(1999)
J Biol Chem
, vol.274
, pp. 30244-30249
-
-
Sanchez, M.A.1
Ullman, B.2
Landfear, S.M.3
Carter, N.S.4
-
29
-
-
0037109159
-
Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity
-
Sankar N, Machado J, Abdulla P, Hilliker AJ, and Coe IR (2002) Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity. Nucleic Acids Res 30:4339-4350.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 4339-4350
-
-
Sankar, N.1
Machado, J.2
Abdulla, P.3
Hilliker, A.J.4
Coe, I.R.5
-
30
-
-
0032732044
-
Substrate depletion upregulates uptake of myo-inositol, glucose and adenosine in Leishmania
-
Seyfang A and Landfear SM (1999) Substrate depletion upregulates uptake of myo-inositol, glucose and adenosine in Leishmania. Mol Biochem Parasitol 104:121-130.
-
(1999)
Mol Biochem Parasitol
, vol.104
, pp. 121-130
-
-
Seyfang, A.1
Landfear, S.M.2
-
31
-
-
0343570061
-
Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum
-
Soulère L, Hoffmann P, Bringaud F, and Périé J (2000) Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum. Bioorg Med Chem Lett 10:1247-1350.
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 1247-1350
-
-
Soulère, L.1
Hoffmann, P.2
Bringaud, F.3
Périé, J.4
-
32
-
-
0032492653
-
An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes
-
Tye C, Kasinathan G, Barrett MP, Brun R, Doyle VE, Fairlamb AH, Weaver R, and Gibert IH (1998) An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes. Bioorg Med Chem Lett 8:811-816.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 811-816
-
-
Tye, C.1
Kasinathan, G.2
Barrett, M.P.3
Brun, R.4
Doyle, V.E.5
Fairlamb, A.H.6
Weaver, R.7
Gibert, I.H.8
-
33
-
-
0021877040
-
Developmental cycles and biology of pathogenic trypanosomes
-
Vickerman K (1985) Developmental cycles and biology of pathogenic trypanosomes. Br Med Bull 41:105-114.
-
(1985)
Br Med Bull
, vol.41
, pp. 105-114
-
-
Vickerman, K.1
-
34
-
-
0037135609
-
Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites
-
Wallace LJ, Candlish D, and de Koning HP (2002) Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites. J Biol Chem 277:26149-26156.
-
(2002)
J Biol Chem
, vol.277
, pp. 26149-26156
-
-
Wallace, L.J.1
Candlish, D.2
de Koning, H.P.3
|