Methylation and expression of gene p16INK4aand RB in breast carcinoma

Chinese Journal of Pathology

Volumn 39, Issue 6, 2010, Pages 377-381

  Zhao, Ting Fang ^a   Shen, Shu Ping ^a   Jiang, Jian Ying ^a   Geng, Hong ^a   Guo, Jian Guo ^a   Xie, Li Ping ^a  

^a BAOTOU MEDICAL COLLEGE   (China)

Author keywords

Breast neoplasms; DNA methylation; Genes,p16; Genes,retinoblastoma

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; ESTROGEN RECEPTOR; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; BREAST TUMOR; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTRADUCTAL CARCINOMA; LYMPH NODE METASTASIS; METABOLISM; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY; TUMOR SUPPRESSOR GENE;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; RECEPTORS, ESTROGEN; RETINOBLASTOMA PROTEIN;

EID: 77954662176     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0529-5807.2010.06.004     Document Type: Article

References (15)

1. INK4aCDKN2A tumor suppressor and its relatives. Biochim Biophys Acta, 1998, 1378(2): 115-177.
2. Van Zee KJ, Calvano JE, Bisogna M. Hypomethylation and increased gene expression of p16INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue. Oncogene, 1998, 16(21): 2723-2727.
3. Woodcock DM, Linsenmeyer ME, Doherty JP, et aL DNA methylation in the promoter region of the p16 ( CDKN2/MTS-1/ INK4A) gene in human breast tumours. Br J Cancer, 1999, 79 (2): 251-256.
4. Bloom HJ, Richardson WW. Histological grading and prognosis in breast cancer. Br J Cancer, 1957, 11(3): 359-377.
5. Herman JG, Graff JR, Myöhänen S, et aL Methylation-specific PCR : a novel PCR assay for methylation status of CpG islands. Proc Nad Acad Sci U S A, 1996, 93(18): 9821-9826.
6. Lu CD, Altieri DC, Tanigawa N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res, 1998, 58 (9): 1808-1812.
7. INK4a in some human primary tumors. Mutat Res, 2003, 530(1-2): 9-17.
8. Holst CR, Nuovo GJ, Esteller M, et aL Methylation of p16 (INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res, 2003, 63(7): 1596-1601.
9. INK4a gene expression and methylation in primary breast cancer: overexpression of p16 messenger RNA is a marker of poor prognosis. Clin Cancer Res, 2000, 6(7): 2777-2787.
10. Milde-Langosch K, Bamberger AM, Rieck G, et al. Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype. Breast Cancer Res Treat, 2001, 67(1): 61-70.
11. Geradts J, Wilson PA. High frequency of aberrant p16 ( INK4A ) expression in human breast cancer. Am J Pathol, 1996, 149(1): 15-20.
12. Li SY, Rong M, Iacopetta B. DNA hypermethylation in breast cancer and its association with clinicopathological features. Cancer Lett, 2006, 237(2): 272-280.
13. Chang HG, Kim SJ, Chung KW, et al. Tamoxifen-resistant breast cancers show less frequent methylation of the estrogen receptor beta but not the estrogen receptor alpha gene. J Mol Med, 2005, 83 (2): 132-139.
14. Silva JM, Dominguez G, Garcia JM, et aL Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations. Cancer Res, 1999, 59(13): 3251-3256.
15. Tao MH, Shields PG, Nie J, et al. DNA hypermethylation and clinicopathological features in breast cancer: the Western New York Exposures and Breast Cancer ( WEB ) Study. Breast Cancer Res Treat, 2009, 114(3): 559-568.