Tamoxifen-resistant breast cancers show less frequent methylation of the estrogen receptor β but not the estrogen receptor α gene

Journal of Molecular Medicine

Volumn 83, Issue 2, 2005, Pages 132-139

  Chang, Ho Gun ^a   Kim, Sun Jung ^a   Chung, Ki Wook ^b   Noh, Dong Young ^b   Kwon, Youngmee ^c   Lee, Eun Sook ^c   Kang, Han Sung ^c  

^a Dongguk University   (South Korea)

^b Seoul National University   (South Korea)

^c National Cancer Center   (South Korea)

Author keywords

Estrogen receptor ; Estrogen receptor ; Methylation; Tamoxifen resistance

Indexed keywords

BISULFITE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; KI 67 ANTIGEN; MESSENGER RNA; TAMOXIFEN;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; METHYLATION; NUCLEOTIDE SEQUENCE; RECEPTOR DENSITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CASE-CONTROL STUDIES; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM RECURRENCE, LOCAL; TAMOXIFEN;

EID: 15044363940     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-004-0596-2     Document Type: Article

References (33)

1. Lohrisch C, Piccart MJ (2001) Standard medical treatment for early breast cancer. Eur J Cancer 37:S45-S58
2. MacGregor JI, Jordan VC (1998) Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 50:151-196
3. Osborne CK, Coronado E, Allred DC, Wiebe V, DeGregorio, M (1991) Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen. J Natl Cancer Inst 83:1477-1482
4. Takimoto GS, Graham JD, Jackson TA, Tung L, Powell RL, Horwitz LD, Horwitz KB (1999) Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors. J Steroid Biochem Mol Biol 69:45-50
5. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H, Metzger D, Chambon P (1995) Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270:1491-1494
6. Cariou S, Donovan J, Flanagan W, Milic A, Bhattacharya N, Slingerland J (2000) Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen- mediated cell cycle arrest in human breast cancer cells. Proc Natl Acad Sci USA 97:9042-9046
7. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138:863-870
8. Jones PA, Laird PW (1999) Cancer epigenetics comes of age. Nat Genet 21:163-167
9. Ottaviano YL, Issa JP, Pari FF, Smith HS, Baylin SB, Davidson NE (1994) Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res 54:2552-2555
10. Issa J-P, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7:536-540
11. Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K (2003) Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene 22:7600-7606
12. Zhuang Z, Bertheau P, Emmert-Buck MR, Liotta, LA, Gnarra J, Linehan WM, Lubensky IA (1995) A microdissection technique for archival DNA analysis of specific cell populations in lesions <1 mm in size. Am J Pathol 146:620-625
13. Kang JH, Kim SJ, Noh DY, Park IA, Choe KJ, Yoo OJ, Kang HS (2001) Methylation in the p53 promoter is a supplementary route to breast carcinogenesis: correlation between CpG methylation in the p53 promoter and the mutation of the p53 gene in the progression from ductal carcinoma in situ to invasive ductal carcinoma. Lab Invest 81:573-579
14. Li LC, Chui R, Nakajima K, Oh BR, Au HC, Dahiya R (2000) Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression. Cancer Res 2000:702-706
15. Li LC, Yeh CC, Nojima D, Dahiya R (2000) Cloning and characterization of human estrogen receptor beta promoter. Biochem Biophys Res Commun 275:682-689
16. Geisler S, Lonning PE, Aas T, Johnsen H, Fluge O, Haugen DF, Lillehaug JR, Akslen LA, Borresen-Dale AL (2001) Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res 61:2505-2512
17. Nishihara E, Nagayama Y, Inoue S, Hiroi H, Muramatsu M, Yamashita S, Koji T (2000) Ontogenetic changes in the expression of estrogen receptor alpha and beta in rat pituitary gland detected by immunohistochemistry. Endocrinology 141:615-620
18. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T (1997) Expression of estrogen receptor beta in rat bone. Endocrinology 138:4509-4512
19. Mosselman S, Pohlman J, Dijkema R (1996) ERβ: identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49-53
20. Enmark E, Pelto-Huikko M, Grandien K, Fried G, Lagerkrantz S, Lagerkranzt J, Nordenskjöld M, Gustafsson JÅ (1997) Human estrogen receptor β: gene structure, chromosomal localisation and expression pattern. J Clin Endocrinol Metab 82:4258-4265
21. Paech K, Webb P, Kuiper GGJM, Nilsson S, Gustaffson JA, Kushner PJ, Scanlan TS (1997) Differential ligand activation of estrogen receptors ERα and ERβ at AP-1 sites. Science 277:1508-1510
22. Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, Giguere V (1997) Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol 11:353-365
23. Speirs V, Malone C, Walton DS, Kerin MJ, Atkin SL (1999) Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients. Cancer Res 59:5421-5424
24. Jensen EV, Cheng G, Palmieri C, Saji S, Makela S, Van Noorden S, Wahlstrom T, Warner M, Coombes RC, Gustafsson JA (2001) Estrogen receptors and proliferation markers in primary and recurrent breast cancer. Proc Natl Acad Sci USA 98:15197-15202
25. Johnston SR, Haynes BP, Smith IE, Jarman M, Sacks NP, Ebbs SR, Dowsett M (1993) Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration. Lancet 342:1521-1522
26. Johnston SR, Saccani-Jotti G, Smith IE, Salter J, Newby J, Coppen M, Ebbs SR, Dowsett M (1995) Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer. Cancer Res 55:3331-3338
27. Robertson JF (1996) Oestrogen receptor: a stable phenotype in breast cancer. Br J Cancer 73:5-12
28. Widschwendter M, Jones PA (2002) DNA methylation and breast carcinogenesis. Oncogene 21:5462-5482
29. Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG (2000) Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 275:2727-2732
30. Cameron EE, Baylin SB, Herman JG (1999) p15 (INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood 94:2445-2451
31. Lehmann U, Langer F, Feist H, Glockner S, Hasemeier B, Kreipe H (2002) Quantitative assessment of promoter hypermethylation during breast cancer development. Am J Pathol 160:605-612
32. Knoop AS, Bentzen SM, Nielsen MM, Rasmussen BB, Rose C (2001) Value of epidermal growth factor receptor, HER2, p53, and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients. J Clin Oncol 19:3376-3384
33. Saji S, Jensen EV, Nilsson S, Rylander T, Warner M, Gustafsson JA (2000) Estrogen receptors α and β in the rodent mammary gland. Proc Natl Acad Sci USA 97:337-342