Plant sterol and stanol substrate specificity of pancreatic cholesterol esterase

Journal of Nutritional Biochemistry

Volumn 21, Issue 8, 2010, Pages 736-740

  Brown, Andrew W ^a   Hang, Jiliang ^a   Dussault, Patrick H ^a   Carr, Timothy P ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Cholesterol absorption; Cholesterol metabolism; Lipase; Phytosterols; Plant stanols; Plant sterols

Indexed keywords

CHOLESTEROL ESTERASE; OLEIC ACID; PALMITIC ACID; PANCREATIC CHOLESTEROL ESTERASE; PHYTOSTEROL; SITOSTANOL; SITOSTEROL; STANOL ESTER; STEARIC ACID; STIGMASTEROL; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; CONTROLLED STUDY; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MICELLIZATION;

ANIMALS; CHOLESTANOL; CHOLESTEROL; HYDROLYSIS; MICE; PLANTS; STEROL ESTERASE; STEROLS; SUBSTRATE SPECIFICITY;

EID: 77954660408     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.04.008     Document Type: Article

References (30)

1. Kung H., Hoyert D.L., Xu J., Murphy S.L. Deaths: final data for 2005. Natl Vital Stat Rep 2008, 56:1-120.
2. Begemann F., Bandomer G., Herget H.J. The influence of beta-sitosterol on biliary cholesterol saturation and bile acid kinetics in man. Scand J Gastroenterol 1978, 13:57-63.
3. Jesch E.D., Carr T.P. Sitosterol reduces micellar cholesterol solubility in model bile. Nutr Res 2006, 26:579-584.
4. Miettinen T.A., Vuoristo M., Nissinen M., Järvinen H.J., Gylling H. Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am J Clin Nutr 2000, 71:1095-1102.
5. Armstrong M.J., Carey M.C. Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. J Lipid Res 1987, 28:1144-1155.
6. Brown J.M., Rudel L.L., Yu L. Npc1l1 (niemann-pick c1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in mcardle-rh7777 hepatoma cells. Biochem J 2007, 406:273-283.
7. Zschörnig O., Pietsch M., Süss R., Schiller J., Gütschow M. Cholesterol esterase action on human high density lipoproteins and inhibition studies: detection by MALDI-TOF MS. J Lipid Res 2005, 46:803-811.
8. Chen Q., Sternby B., Nilsson A. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. Biochim Biophys Acta 1989, 1004:372-385.
9. Mozingo R Catalyst, raney nickel, W-2. Org Synth 1941, 21:15-17. Org. Synth. Coll. Vol. 1955;3:181.
10. Kircher H.W., Rosenstein F.U. Hydrogenation of stigmasterol. Lipids 1973, 8(3):101-106.
11. Xie M., Qiu A., He Y. Catalytic hydrogenation of stigmasterol to sitostanol. Jingxi Huagong 2004, 21(10):735-737.
12. Kukis A., Beveridge J.M.R. Preparation and physical properties of some plant steryl esters. J Org Chem 1960, 25:1209-1219.
13. Cohen D.E., Carey M.C. Rapid (1 hour) high performance gel filtration chromatography resolves coexisting simple micelles, mixed micelles, and vesicles in bile. J Lipid Res 1990, 31:2103-2112.
14. Carr T.P., Jesch E.D. Food components that reduce cholesterol absorption. Adv Food Nutr Res 2006, 51:165-204.
15. Health claims: plant sterol/stanol esters and risk of coronary heart disease (CHD), 21 C.F.R. Sect. 101.83 (Apr. 1, 2008).
16. IOM. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington DC: National Academies Press; 2005. pp. 1038, 1058.
17. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
18. Garcia-Calvo M., Lisnock J., Bull H.G., Hawes B.E., Burnett D.A., Braun M.P., et al. The target of ezetimibe is niemann-pick c1-like 1 (npc1l1). Proc Natl Acad Sci U S A 2005, 102:8132-8137.
19. Heynekamp J.J., Hunsaker L.A., Vander Jagt T.A., Royer R.E., Deck L.M., Vander Jagt D.L. Isocoumarin-based inhibitors of pancreatic cholesterol esterase. Bioorg Med Chem 2008, 16:5285-5294.
20. Vahouny G.V., Weersing S., Treadwell C.R. Micellar-solubilized substrates and cholesterol esterase activity in vitro. Arch Biochem Biophys 1964, 107:7-15.
21. Johnson R.C., Shah S.N. Evidence for two cholesterol ester hydrolases in human cerebrospinal fluid. J Neurochem 1981, 37:594-596.
22. Jacobson P.W., Wiesenfeld P.W., Gallo L.L., Tate R.L., Osborne J.C.J. Sodium cholate-induced changes in the conformation and activity of rat pancreatic cholesterol esterase. J Biol Chem 1990, 265:515-521.
23. Nègre A., Salvayre R., Rogalle P., Dang Q.Q., Douste-Blazy L. Acyl-chain specificity and properties of cholesterol esterases from normal and Wolman lymphoid cell lines. Biochim Biophys Acta 1987, 918:76-82.
24. Ponz de Leon M., Carubbi F., Di Donato P., Carulli N. Cholesterol esterase activity of human intestinal mucosa. Dig Dis Sci 1985, 30:1053-1064.
25. Durham L.A., Grogan W.M. Characterization of multiple forms of cholesteryl ester hydrolase in the rat testis. J Biol Chem 1984, 259:7433-7438.
26. Nissinen M.J., Gylling H., Miettinen T.A. Effects of plant stanol esters supplied in a fat free milieu by pastilles on cholesterol metabolism in colectomized human subjects. Nutr Metab Cardiovasc Dis 2006, 16:426-435.
27. Tachibana S., Hirano M., Hirata T., Matsuo M., Ikeda I., Ueda K., et al. Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters. Biosci Biotechnol Biochem 2007, 71:1886-1895.
28. Ikeda I., Tanaka K., Sugano M., Vahouny G.V., Gallo L.L. Inhibition of cholesterol absorption in rats by plant sterols. J Lipid Res 1988, 29:1573-1582.
29. Nissinen M., Gylling H., Vuoristo M., Miettinen T.A. Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. Am J Physiol Gastrointest Liver Physiol 2002, 282:G1009-G1015.
30. Plat J., van Onselen E.N., van Heugten M.M., Mensink R.P. Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur J Clin Nutr 2000, 54:671-677.