An electronic tongue: Evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine

AAPS PharmSciTech

Volumn 11, Issue 2, 2010, Pages 550-557

  Rachid, Ousama ^a   Simons, F Estelle R ^b   Rawas Qalaji, Mutasem ^c   Simons, Keith J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

Anaphylaxis; Artificial sweeteners; Electronic tongue; Epinephrine; Sublingual tablet

Indexed keywords

ACESULFAME; ADRENALIN; ASPARTAME; CITRIC ACID; FLAVORING AGENT; SWEETENING AGENT; TARTARIC ACID; BIOMIMETIC MATERIAL;

ARTICLE; BITTER TASTE; CALIBRATION; CONTROLLED STUDY; DRUG SCREENING; ELECTRONIC TONGUE; MEDICAL INSTRUMENTATION; PRIORITY JOURNAL; SCORING SYSTEM; SENSORY ANALYSIS; TASTE DISCRIMINATION; VALIDATION PROCESS; ANIMAL; CHEMISTRY; CONDUCTOMETRY; DEVICE FAILURE ANALYSIS; DEVICES; ELECTRONICS; EQUIPMENT DESIGN; EVALUATION STUDY; HUMAN; PHARMACEUTICS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TASTE; TONGUE;

ANIMALS; BIOMIMETIC MATERIALS; CONDUCTOMETRY; DRUG EVALUATION, PRECLINICAL; ELECTRONICS; EPINEPHRINE; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLAVORING AGENTS; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TASTE; TECHNOLOGY, PHARMACEUTICAL; TONGUE;

EID: 77954659541     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9402-3     Document Type: Article

References (30)

1. Ayenew Z, Puri V, Kumar L, Bansal AK. Trends in pharmaceutical taste masking technologies: a patent review. Recent Pat Drug Deliv Formul. 2009;3(1):26-39.
2. Repchinsky C. Compendium of pharmaceuticals and specialties: the Canadian drug reference for health professionals. 44th ed. Toronto: Canadian Pharmacists Association; 2009.
3. Mennella JA, Beauchamp GK. Optimizing oral medications for children. Clin Ther. 2008;30(11):2120-32.
4. Liberman DB, Teach SJ. Management of anaphylaxis in children. Pediatr Emerg Care. 2008;24(12):861-6.
5. Simons F E R. Anaphylaxis: recent advances in assessment and treatment. J Allergy Clin Immunol. 2009;124(4):625-36.
6. Rawas-Qalaji MM, Simons F E R, Simons KJ. Fast-Disintegrating Sublingual Tablets: Effect of Epinephrine Load on Tablet characteristics. AAPS PharmSciTech. 2006;7(2): Article 41.
7. Rawas-Qalaji MM, Simons F E R, Simons KJ. Sublingual epinephrine tablets versus intramuscular injection of epinephrine: dose equivalence for potential treatment of anaphylaxis. J Allergy Clin Immunol. 2006;117(2):398-403.
8. Rawas-Qalaji MM, Simons F E R, Simons KJ. Epinephrine for the treatment of anaphylaxis: do all 40 mg sublingual epinephrine tablet formulations with similar in vitro characteristics have the same bioavailability? Biopharm Drug Dispos. 2006;27(9):427-35.
9. Lorenz JK, Reo JP, Hendl O, Worthington JH, Petrossian VD. Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development. Int J Pharm. 2009;367(1-2):65-72.
10. Zheng JY, Keeney MP. Taste masking analysis in pharmaceutical formulation development using an electronic tongue. Int J Pharm. 2006;310(1-2):118-24.
11. Takagi S, Toko K, Wada K, Ohki T. Quantification of suppression of bitterness using an electronic tongue. J Pharm Sci. 2001;90(12):2042-8.
12. Sadrieh N, Brower J, Yu L, Doub W, Straughn A, Machado S et al. Stability, dose uniformity, and palatability of three counterterrorism drugs-human subject and electronic tongue studies. Pharm Res. 2005;22(10):1747-56.
13. Kayumba PC, Huyghebaert N, Cordella C, Ntawukuliryayo JD, Vervaet C, Remon JP. Quinine sulphate pellets for flexible pediatric drug dosing: formulation development and evaluation of taste-masking efficiency using the electronic tongue. Eur J Pharm Biopharm. 2007;66(3):460-5.
14. Li L, Naini V, Ahmed SU. Utilization of a modified special-cubic design and an electronic tongue for bitterness masking formulation optimization. J Pharm Sci. 2007;96(10):2723-34.
15. Tokuyama E, Matsunaga C, Yoshida K, Mifsud JC, Irie T, Yoshida M et al. Famotidine orally disintegrating tablets: bitterness comparison of original and generic products. Chem Pharm Bull (Tokyo). 2009;57(4):382-7.
16. Alpha M O S. Astree electrochemical sensor technology-Technical note: T-SAS-04. 2004.
17. Mifsud J.-C., Lucas Q. Alpha M. O. S. Apparatus and method for characterizing liquids. US Patent. 2003;6, 290, 838. Application No. 380663. Filed November 22, 1999.
18. Keef KA. Sympathomimetic drugs. In: Hendrickson R, chairman of the editorial board. Remington: The science and practice of pharmacy. 21st ed. Baltimore, Md: Lippincott Williams & Wilkins; 2005. p. 1386.
19. Sciarra JJ, Patel JM, Kapoor AL. Synthesis and formulation of several epinephrine salts as an aerosol dosage form. J Pharm Sci. 1972;61(2):219-23.
20. Ikeda K. New seasonings. Chem Senses. 2002;27(9):847-9.
21. Rowe RC, Sheskey PJ, Weller PJ. Handbook of pharmaceutical excipients. 4th ed. London: The Pharmaceutical Press; 2003.
22. Goel H, Rai P, Rana V, Tiwary AK. Orally disintegrating systems: innovations in formulation and technology. Recent Pat Drug Deliv Formul. 2008;2(3):258-74.
23. Hagiwara A, Fukushima S, Kitaori M, Shibata M, Ito N. Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gann. 1984;75:763-8. (Pubitemid 14015674)
24. Ishii H. Incidence of brain tumors in rats fed aspartame. Toxicol Lett. 1981;7:433-7.
25. Magnuson B, Williams GM. Carcinogenicity of aspartame in rats not proven. Environ Health Perspect. 2008;116(6):A239-40.
26. Whitehouse CR, Boullata J, McCauley LA. The potential toxicity of artificial sweeteners. AAOHN J. 2008;56(6):251-9.
27. Bandyopadhyay A, Ghoshal S, Mukherjee A. Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin. Drug Chem Toxicol. 2008;31(4):447-57.
28. Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW et al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727.
29. Liem DG, Westerbeek A, Wolterink S, Kok FJ, de Graaf C. Sour taste preferences of children relate to preference for novel and intense stimuli. Chem Senses. 2004;29:713-20.
30. Sakurai T, Misaka T, Nagai T, Ishimaru Y, Matsuo S, Asakura T et al. pH-Dependent inhibition of the human bitter taste receptor hTAS2R16 by a variety of acidic substances. J Agric Food Chem. 2009;57(6):2508-14.