Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway

Microbial Pathogenesis

Volumn 49, Issue 3, 2010, Pages 95-104

  Cho, Kyung Ah ^a   Jun, Yoon Hee ^b   Suh, Jee Won ^a   Kang, Jae Seung ^c   Choi, Hee Jung ^b   Woo, So Youn ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Mokdong Hospital   (South Korea)

^c Inha University School of Medicine   (South Korea)

Author keywords

Endothelial cells; IL 32; NOD1; Orientia tsutsugamushi

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 4; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 32; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN; RANTES; SMALL INTERFERING RNA; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; IL32 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; NOD1 PROTEIN, HUMAN;

ARTICLE; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA FLANKING REGION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; ORIENTIA TSUTSUGAMUSHI; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCRUB TYPHUS; BIOSYNTHESIS; GENE SILENCING; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PATHOGENICITY; SECRETION (PROCESS);

CELL LINE; CYTOKINES; ENDOTHELIAL CELLS; GENE SILENCING; HUMANS; INTERLEUKINS; NOD1 SIGNALING ADAPTOR PROTEIN; ORIENTIA TSUTSUGAMUSHI; RNA, SMALL INTERFERING;

BACTERIA (MICROORGANISMS); ORIENTIA TSUTSUGAMUSHI;

EID: 77954658996     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2010.05.001     Document Type: Article

References (44)

1. Jeong Y.J., Kim S., Wook Y.D., Lee J.W., Kim K.I., Lee S.H. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 2007, 27:161-172.
2. Cho N.H., Seong S.Y., Choi M.S., Kim I.S. Expression of chemokine genes in human dermal microvascular endothelial cell lines infected with Orientia tsutsugamushi. Infect Immun 2001, 69:1265-1272.
3. Cho N.H., Seong S.Y., Huh M.S., Han T.H., Koh Y.S., Choi M.S., et al. Expression of chemokine genes in murine macrophages infected with Orientia tsutsugamushi. Infect Immun 2000, 68:594-602.
4. Moron C.G., Popov V.L., Feng H.M., Wear D., Walker D.H. Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus. Mod Pathol 2001, 14:752-759.
5. Rikihisa Y., Ito S. Intracellular localization of Rickettsia tsutsugamushi in polymorphonuclear leukocytes. J Exp Med 1979, 150:703-708.
6. Chung D.R., Lee Y.S., Lee S.S. Kinetics of inflammatory cytokines in patients with scrub typhus receiving doxycycline treatment. J Infect 2008, 56:44-50.
7. Kanneganti T.D., Lamkanfi M., Nunez G. Intracellular NOD-like receptors in host defense and disease. Immunity 2007, 27:549-559.
8. Opitz B., Forster S., Hocke A.C., Maass M., Schmeck B., Hippenstiel S., et al. Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res 2005, 96:319-326.
9. Opitz B., Puschel A., Beermann W., Hocke A.C., Forster S., Schmeck B., et al. Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J Immunol 2006, 176:484-490.
10. Greiffenberg L., Goebel W., Kim K.S., Daniels J., Kuhn M. Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: an electron microscopic study. Infect Immun 2000, 68:3275-3279.
11. Slaghuis J., Goetz M., Engelbrecht F., Goebel W. Inefficient replication of Listeria innocua in the cytosol of mammalian cells. J Infect Dis 2004, 189:393-401.
12. Rose F., Zeller S.A., Chakraborty T., Domann E., Machleidt T., Kronke M., et al. Human endothelial cell activation and mediator release in response to Listeria monocytogenes virulence factors. Infect Immun 2001, 69:897-905.
13. Opitz B., Puschel A., Schmeck B., Hocke A.C., Rosseau S., Hammerschmidt S., et al. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem 2004, 279:36426-36432.
14. Arisoy M., Aysev D., Ekim M., Ozel D., Kose S.K., Ozsoy E.D., et al. Detection of virulence factors of Escherichia coli from children by multiplex polymerase chain reaction. Int J Clin Pract 2006, 60:170-173.
15. Nold-Petry C.A., Nold M.F., Zepp J.A., Kim S.H., Voelkel N.F., Dinarello C.A. IL-32-dependent effects of IL-1beta on endothelial cell functions. Proc Natl Acad Sci U S A 2009, 106:3883-3888.
16. Yoo N.J., Park W.S., Kim S.Y., Reed J.C., Son S.G., Lee J.Y., et al. Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1. Biochem Biophys Res Commun 2002, 299:652-658.
17. Nacy C.A., Groves M.G. Macrophages in resistance to rickettsial infections: early host defense mechanisms in experimental scrub typhus. Infect Immun 1981, 31:1239-1250.
18. Koh Y.S., Yun J.H., Seong S.Y., Choi M.S., Kim I.S. Chemokine and cytokine production during Orientia tsutsugamushi infection in mice. Microb Pathog 2004, 36:51-57.
19. Iwasaki H., Takada N., Nakamura T., Ueda T. Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection. J Clin Microbiol 1997, 35:3320-3322.
20. Baggiolini M., Dewald B., Moser B. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 1994, 55:97-179.
21. Paris D.H., Jenjaroen K., Blacksell S.D., Phetsouvanh R., Wuthiekanun V., Newton P.N., et al. Differential patterns of endothelial and leucocyte activation in 'typhus-like' illnesses in Laos and Thailand. Clin Exp Immunol 2008, 153:63-67.
22. Fritz J.H., Ferrero R.L., Philpott D.J., Girardin S.E. Nod-like proteins in immunity, inflammation and disease. Nat Immunol 2006, 7:1250-1257.
23. Werts C., Girardin S.E., Philpott D.J. TIR, CARD and PYRIN: three domains for an antimicrobial triad. Cell Death Diff 2006, 13:798-815.
24. Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cells 2002, 10:417-426.
25. Chamaillard M., Girardin S.E., Viala J., Philpott D.J. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol 2003, 5:581-592.
26. Inohara N., Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 2003, 3:371-382.
27. Hanson B. Identification and partial characterization of Rickettsia tsutsugamushi major protein immunogens. Infect Immun 1985, 50:603-609.
28. Oaks E.V., Rice R.M., Kelly D.J., Stover C.K. Antigenic and genetic relatedness of eight Rickettsia tsutsugamushi antigens. Infect Immun 1989, 57:3116-3122.
29. Tamura A., Ohashi N., Urakami H., Takahashi K., Oyanagi M. Analysis of polypeptide composition and antigenic components of Rickettsia tsutsugamushi by polyacrylamide gel electrophoresis and immunoblotting. Infect Immun 1985, 48:671-675.
30. Ihn K.S., Han S.H., Kim H.R., Huh M.S., Seong S.Y., Kang J.S., et al. Cellular invasion of Orientia tsutsugamushi requires initial interaction with cell surface heparan sulfate. Microb Pathog 2000, 28:227-233.
31. Kim H.R., Choi M.S., Kim I.S. Role of Syndecan-4 in the cellular invasion of Orientia tsutsugamushi. Microb Pathog 2004, 36:219-225.
32. Franchi L., Warner N., Viani K., Nunez G. Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 2009, 227:106-128.
33. Cheng Q., Park J.T. Substrate specificity of the AmpG permease required for recycling of cell wall anhydro-muropeptides. J Bacteriol 2002, 184:6434-6436.
34. Netea M.G., Azam T., Ferwerda G., Girardin S.E., Walsh M., Park J.S., et al. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A 2005, 102:16309-16314.
35. Netea M.G., Azam T., Lewis E.C., Joosten L.A., Wang M., Langenberg D., et al. Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med 2006, 3:e277.
36. Kim M.J., Kim M.K., Kang J.S. Orientia tsutsugamushi inhibits tumor necrosis factor alpha production by inducing interleukin 10 secretion in murine macrophages. Microb Pathog 2006, 40:1-7.
37. Kim M.K., Kang J.S. Orientia tsutsugamushi suppresses the production of inflammatory cytokines induced by its own heat-stable component in murine macrophages. Microb Pathog 2001, 31:145-150.
38. Kang J.W., Choi S.C., Cho M.C., Kim H.J., Kim J.H., Lim J.S., et al. A proinflammatory cytokine interleukin-32beta promotes the production of an anti-inflammatory cytokine interleukin-10. Immunology 2009, 128:e532-e540.
39. Dahl C.A., Schall R.P., He H.L., Cairns J.S. Identification of a novel gene expressed in activated natural killer cells and T cells. J Immunol 1992, 148:597-603.
40. Choi J.D., Bae S.Y., Hong J.W., Azam T., Dinarello C.A., Her E., et al. Identification of the most active interleukin-32 isoform. Immunology 2009, 126:535-542.
41. Kim S.H., Han S.Y., Azam T., Yoon D.Y., Dinarello C.A. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity 2005, 22:131-142.
42. Mun S.H., Kim J.W., Nah S.S., Ko N.Y., Lee J.H., Kim J.D., et al. Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum 2009, 60:678-685.
43. Li W., Yang F., Liu Y., Gong R., Liu L., Feng Y., et al. Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. Eur J Immunol 2009, 39:1019-1024.
44. Mabilleau G., Sabokbar A. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS One 2009, 4:e4173.