Restoring airway surface liquid in cystic fibrosis

New England Journal of Medicine

Volumn 354, Issue 3, 2006, Pages 291-293

  Ratjen, Felix ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; DEOXYRIBONUCLEASE; MANNITOL; SODIUM CHANNEL; SODIUM CHLORIDE; TOBRAMYCIN;

ACTIVE TRANSPORT; CLINICAL TRIAL; CYSTIC FIBROSIS; DRUG EFFECT; EDITORIAL; EPITHELIUM CELL; GRAM NEGATIVE INFECTION; HUMAN; LUNG CLEARANCE; LUNG FUNCTION; MUCOCILIARY TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT DISEASE;

ADMINISTRATION, INHALATION; ANTI-BACTERIAL AGENTS; COUGH; CYSTIC FIBROSIS; DRUG THERAPY, COMBINATION; HUMANS; MUCOCILIARY CLEARANCE; PULMONARY VENTILATION; SALINE SOLUTION, HYPERTONIC; WATER;

EID: 30944452609     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe058293     Document Type: Editorial

References (8)

1. Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 2004;10:487-93.
2. Wark PA, McDonald V, Jones AP. Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev 2005;3:CD001506.
3. Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 2006;354:241-50.
4. Elkins MR, Robinson M, Rose BR, et al. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 2006;354:229-40.
5. Ramsey BW, Pepe MS, Quan JM, et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. N Engl J Med 1999;340:23-30.
6. Fuchs HJ, Borowitz DS, Christiansen DH, et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. N Engl J Med 1994;331:637-42.
7. Suri R, Metcalfe C, Lees B, et al. Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial. Lancet 2001;358:1316-21.
8. Chan HK, Eberl S, Daviskas E, Constable C, Young I. Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study. J Aerosol Med 2002;15:307-11.