Effect of the preparation method on the drug loading of alginate-chitosan microspheres

Express Polymer Letters

Volumn 4, Issue 8, 2010, Pages 456-464

  Abreu, F O M S ^a   Forte, M M C ^b   Kist, T B L ^b   Honaiser, L P ^b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Biodegradable polymers; Chitosan; Drug loading; Microspheres; Polymer gels

Indexed keywords

EID: 77954641654     PISSN: 1788618X     EISSN: None     Source Type: Journal    
DOI: 10.3144/expresspolymlett.2010.58     Document Type: Article

References (21)

1. Berger J., Reist M., Mayer J. M., Felt O., Peppas N. A., Gurny R.: Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. European Journal of Pharmaceutics and Biopharmaceutics, 57, 19-34 (2004). DOI: 10.1016/S0939-6411(03)00161-9
2. Sinha V. R., Singla A. K., Wadhawan S., Kaushik R., Kumria R., Bansal K., Dhawan S.: Chitosan microspheres as a potential carrier for drugs. International Journal of Pharmaceutics, 274, 1-33 (2004). DOI: 10.1016/j.ijpharm.2003.12.026
3. George M., Abraham T. E.: Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan- A review. Journal of Controlled Release, 114, 1-14 (2006). DOI: 10.1016/j.jconrel.2006.04.017
4. De S., Robinson D.: Polymer relationships during preparation of chitosan-alginate and poly-l-lysinealginate nanospheres. Journal of Controlled Release, 89, 101-112 (2003). DOI: 10.1016/S0168-3659(03)00098-1
5. Ribeiro A. J., Silva C., Ferreira D., Veiga A.: Chitosan- reinforced alginate microspheres obtained through the emulsification/internal gelation technique. European Journal of Pharmaceutical Science, 25, 31- 40 (2005). DOI: 10.1016/j.ejps.2005.01.016
6. Wittaya-areekul S., Kruenate J., Prahsarn E. C.: Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone. International Journal of Pharmaceutics, 312, 113-118 (2006). DOI: 10.1016/j.ijpharm.2006.01.003
7. Alsarra I. A., Betigeri S. S., Zhang H., Evans B. A., Neau S. H.: Molecular weight and degree of deacetylation effects on lipase-loaded chitosan bead characteristics. Biomaterials, 23, 3637-3644 (2002). DOI: 10.1016/S0142-9612(02)00096-0
8. Abreu F. O. M. S., Bianchini C., Forte M. M. C., Kist T. B. L.: Influence of the composition and preparation method on the morphology and swelling behavior of alginate-chitosan hydrogels. Carbohydrate Polymers, 74, 283-289 (2008). DOI: 10.1016/j.carbpol.2008.02.017
9. Abreu F. O. M. S., Bianchini C., Kist T. B. L., Forte M. M. C.: Preparation and properties of core-shell alginate-carboxymethylchitosan hydrogels. Polymer International, 58, 1267-1274 (2009). DOI: 10.1002/pi.2657
10. Kim W-T., Chung H., Shin I-S., Yam K. L., Chung D.: Characterization of calcium alginate and chitosantreated calcium alginate gel beads entrapping allyl isothiocyanate. Carbohydrate Polymers, 71, 566-573 (2008). DOI: 10.1016/j.carbpol.2007.06.028
11. Wang L-Y., Ma G-H., Su Z-G.: Preparation of uniform sized chitosan microspheres by membrane emulsification technique and application as a carrier of protein drug. Journal of Controlled Release, 106, 62- 75 (2005). DOI: 10.1016/j.jconrel.2005.04.005
12. Kofuji K., Qian C-J., Murata Y., Kawashima S.: Preparation of chitosan microparticles by water-invegetable oil emulsion coalescence technique. Reactive and Functional Polymers, 62, 77-83 (2005). DOI: 10.1016/j.reactfunctpolym.2004.09.002
13. Wang L-Y., Gu Y-H., Zhou Q-Z., Ma G-H., Wan YH., Su Z-G.: Preparation and characterization of uniform- sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification process. Colloids and Surfaces B: Biointerfaces, 50, 126-135 (2006). DOI: 10.1016/j.colsurfb.2006.05.006
14. Zhi J., Wang Y., Lu Y., Ma J., Luo G.: In situ preparation of magnetic chitosan/Fe3O4 composite nanoparticles in tiny pools of water-in-oil microemulsion. Reactive and Functional Polymers, 66, 1552-1558 (2006). DOI: 10.1016/j.reactfunctpolym.2006.05.006
15. Liu G., Shao L., Ge F., Chen J.: Preparation of ultrafine chitosan particles by reverse microemulsion. China Particuology, 5, 384-390 (2007). DOI: 10.1016/j.cpart.2007.08.002
16. Hamidi M., Azadi A., Rafiei P.: Hydrogel nanoparticles in drug delivery. Advanced Drug Delivery Reviews, 60, 1638-1649 (2008). DOI: 10.1016/j.addr.2008.08.002
17. Gaserod O., Smidsrod O., Skjak-Braek G.: Microcapsules of alginate-chitosan-I: A quantitative study of the interaction between alginate and chitosan. Biomaterials, 19, 1815-1825 (1998). DOI: 10.1016/S0142-9612(98)00073-8
18. Banerjee T., Mitra S., Singh A. K., Sharma R. K., Maitr A.: Preparation, characterization and biodistribution of ultrafine chitosan nanoparticles. International Journal of Pharmaceutics, 243, 93-105 (2002). DOI: 10.1016/S0378-5173(02)00267-3
19. Moura M. J., Figueiredo M. M., Gil M. H.: Rheological study of genipin cross-linked chitosan hydrogels. Biomacromolecules, 8, 3823-3829 (2007). DOI: 10.1021/bm700762w
20. Mi F-L., Sung H-W., Shyu S-S.: Drug release from chitosan-alginate complex beads reinforced by a naturally occurring cross-linking agent. Carbohydrate Polymers, 48, 61-72 (2002). DOI: 10.1016/S0144-8617(01)00212-0
21. Zhu A., Dai S., Li L., Zhao F.: Salt effects on aggregation of O-carboxymethylchitosan in aqueous solution. Colloids and Surfaces B: Biointerfaces, 47, 20-28 (2006). DOI: 10.1016/j.colsurfb.2005.11.020