Fetal Malnutrition Affects Hypothalamic Leptin Receptor Expression After Birth in Male Mice

Archives of Medical Research

Volumn 41, Issue 4, 2010, Pages 240-245

  Manuel Apolinar, Leticia ^a   Zarate, Arturo ^a   Rocha, Luisa ^b   Hernández, Marcelino ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Fetal malnutrition; Hypothalamus; Leptin; Receptor Ob Rb

Indexed keywords

LEPTIN RECEPTOR; MESSENGER RNA; PRIMER DNA;

ADAPTATION; ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BIRTH; BODY WEIGHT; CALORIC RESTRICTION; CONTROL GROUP; CONTROLLED STUDY; DIET RESTRICTION; ENVIRONMENTAL FACTOR; FEMALE; FETAL MALNUTRITION; FOOD INTAKE; HYPOTHALAMUS; MALE; MALNUTRITION; MATING; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PROGENY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WEIGHT GAIN; ANIMAL; BIRTH WEIGHT; CASE CONTROL STUDY; FEEDING BEHAVIOR; FETUS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY;

ANIMALS; BASE SEQUENCE; BIRTH WEIGHT; CASE-CONTROL STUDIES; DNA PRIMERS; FEEDING BEHAVIOR; FEMALE; FETUS; HYPOTHALAMUS; MALE; MALNUTRITION; MICE; MICE, INBRED BALB C; PREGNANCY; RECEPTORS, LEPTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WEIGHT GAIN;

EID: 77954636009     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2010.06.002     Document Type: Article

References (39)

1. Barker D.J. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. Br Med J 1989, 298:654-657.
2. Barker D.J., Hales C.N., Fall C.H., et al. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993, 36:62-67.
3. Hales C.N., Barker D.J. The thrifty phenotype hypothesis. Br Med Bull 2001, 60:5-20.
4. Bispham J., Gopalakrishnan G.S., Dandrea J., et al. Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development. Endocrinology 2003, 144:3575-3585.
5. Boersma B., Wit J.M. Catch up growth. Endocr Rev 1997, 18:646-661.
6. Desai M., Hales C.N. Role of fetal and infant growth in programming metabolism in later life. Biol Rev 1997, 72:329-348.
7. Langley-Evans S.C., Bellinger L., McMullen S. Animal models of programming: early life influences on appetite and feeding behavior. Matern Child Nutr 2005, 1:142-148.
8. Metges C.C. Early nutrition and later obesity: animal models provide insights into mechanisms. Adv Exp Med Biol 2009, 646:105-112.
9. Ozanne S.E. Metabolic programming in animals. Br Med Bull 2001, 60:143-152.
10. Ozanne S.E., Fernandez-Twinn D., Hales C.N. Fetal growth and adult diseases. Semin Perinatol 2004, 28:81-87.
11. Gluckman P.D., Cutfield W., Hofman P., et al. The fetal, neonatal, and infant environments-the long-term consequences for disease risk. Early Hum Dev 2005, 81:51-59.
12. Vickers M.H., Breier B.H., Cutfield W.S., et al. Fetal origin of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab 2000, 279:E83-E87.
13. Bouret S.G., Draper S.J., Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004, 304:108-114.
14. Bouret S.G., Simerly R.B. Minireview. Leptin and development of hypothalamic feeding circuits. J Clin Endocrinol Metab 2004, 145:2621-2626.
15. Harvey J., Ashford M.L. Leptin in the CNS: much more than a satiety signal. Neuropharmacology 2003, 44:845-854.
16. Malik K.F., Young W.S. Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinology 1996, 137:1497-1500.
17. de Oliveira C.C., Teixeira C.V., Passos M.C., et al. Leptin treatment during the neonatal period is associated with higher food intake and adult body weight in rats. Horm Metab Res 2002, 34:400-405.
18. Passos M.C., Vicente L.L., Lisboa P.C., et al. Absence of anorectic effect to acute peripheral leptin treatment in adult rats whose were malnourished during lactation. Horm Metab Res 2004, 36:625-629.
19. Pereira-Toste F., Toste F.P., Oliveira E., et al. Early maternal hyperlpetinemia programs adipogenic phenotype in rats. Horm Metab Res 2009, 41:874-879.
20. Fried S., Ricci M., Russell C.D., et al. Regulation of leptin production in humans. J Nutr 2000, 130:312S-313S.
21. Shigeo Y., Sagawa N., Yamamoto H., et al. Role of premature surge in obesity resulting from intrauterine undernutrition. Cell Metabolism 2005, 1:371-378.
22. Vickers M.H., Krechowec S.O., Breier B.H. Is later obesity programmed in utero?. Current Drug Targets 2007, 8:923-934.
23. Jiménez-Chillaron J.C., Hernández-Valencia M., Lightner A., et al. Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight. Diabetologia 2006, 49:1974-1984.
24. Hernández-Valencia M., Jiménez-Chillaron J.C., Reamer C., et al. β-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Diabetes 2005, 54:702-711.
25. Mistry A.M., Swick A., Romsos D.R. Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice. Am J Physiol 1999, 277:R742-R747.
26. Proulx K., Richard D., Walker C.D. Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Endocrinology 2002, 143:4683-4692.
27. Vickers M.H., Reddy S., Ikenasio B.A., et al. Dysregulation of the adipoinsular axis-a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming. J Endocrinol 2001, 170:323-332.
28. Coupé B., Grit I., Darmaun D., et al. The timing of " catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol 2009, 297:R813-R824.
29. Cottrell E.C., Cripps R.L., Duncan J.S., et al. Developmental changes in hypothalamic leptin receptor: relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat. Am J Physiol Regul Integr Comp Physiol 2009, 296:R631-R639.
30. Yura S., Itoh H., Sagawa N., et al. Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell Metab 2005, 1:371-378.
31. Vickers M.H., Breier B.H., McCarthy D., et al. Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition. Am J Physiol Regul Integr Comp Physiol 2003, 285:R271-R273.
32. Ladyman S.R., Grattan D.R. Region-specific reduction in leptin induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy. Endocrinology 2004, 145:3704-3711.
33. Ladyman S.R., Grattan D.R. Suppression of leptin receptor mRNA and leptin responsiveness in the ventromedial nucleus of the hypothalamus during pregnancy in the rat. Endocrinology 2005, 146:3868-3874.
34. Mitchell S.E., Nogueiras R., Morris A., et al. Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status. J Physiol 2009, 587:3573-3585.
35. Taylor P.D., Poston L. Developmental programming of obesity in mammals. Exp Physiol 2007, 92:287-298.
36. Jones A.P., Simson E.L., Friedman M.I. Gestational undernutrition and the development of obesity in rats. J Nutr 1984, 114:1484-1492.
37. Breier B., Vickers M., Ikenasio B., et al. Fetal programming of appetite and obesity. Mol Cell Endocrinol 2001, 185:73-79.
38. Eleftheriades M., Creatsas G., Nicolaides K. Fetal growth restriction and postnatal development. Ann NY Acad Sci 2006, 1092:319-330.
39. McMillen I.C., Robinson J.S. Developmental origins of the metabolic syndrome: prediction, plasticity. programming Physiol Rev 2005, 85:571-633.