Determination of five phthalate monoesters in human urine using gas chromatography-mass spectrometry

Bulletin of Environmental Contamination and Toxicology

Volumn 85, Issue 1, 2010, Pages 92-96

  Kondo, Fumio ^a,e   Ikai, Yoshitomo ^a   Hayashi, Rumiko ^a   Okumura, Masanao ^a   Takatori, Satoshi ^b   Nakazawa, Hiroyuki ^c   Izumi, Shun Ichiro ^d   Makino, Tsunehisa ^d  

^a AICHI PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^b OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c HOSHI UNIVERSITY   (Japan)

^d TOKAI UNIVERSITY   (Japan)

^e AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Exposure; Gas chromatography mass spectrometry; Phthalate monoesters; Urine

Indexed keywords

COEFFICIENTS OF VARIATIONS; DECONJUGATION; DIAZOMETHANES; DIISONONYL PHTHALATE; EXPOSURE LEVEL; FLORISIL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY METHODS; GC-MS ANALYSIS; GLUCURONIDES; HUMAN URINE; MEAN CONCENTRATIONS; MEDIAN CONCENTRATION; MONO-(2-ETHYLHEXYL)PHTHALATE; MONOESTERS; PHTHALATE MONOESTERS; PHTHALATES;

BODY FLUIDS; ESTERS; HEXANE; MASS SPECTROMETRY; POTASSIUM COMPOUNDS;

GAS CHROMATOGRAPHY;

DRUG DERIVATIVE; ESTER; GLUCURONIDE; HEXANE; MONO (2 ETHYLHEXYL)PHTHALATE; MONO-(2-ETHYLHEXYL)PHTHALATE; MONOISONONYLPHTHALATE; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID BUTYL ESTER; PHTHALIC ACID DERIVATIVE; PLASTICIZER; SOLVENT; MONOBUTYL PHTHALATE; POLLUTANT;

ADULT; ARTICLE; CHEMISTRY; FEMALE; HUMAN; JAPAN; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; MIDDLE AGED; POLLUTANT; URINE; ANALOGS AND DERIVATIVES;

ADULT; DIETHYLHEXYL PHTHALATE; ENVIRONMENTAL POLLUTANTS; ESTERS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCURONIDES; HEXANES; HUMANS; JAPAN; MALE; MIDDLE AGED; PHTHALIC ACIDS; PLASTICIZERS; SOLVENTS;

EID: 77954623065     PISSN: 00074861     EISSN: 14320800     Source Type: Journal    
DOI: 10.1007/s00128-010-0051-8     Document Type: Article

References (19)

1. BC Blount MJ Silva SP Caudill LL Needham JL Pirkle EJ Sampson 2000 Levels of seven urinary phthalate metabolites in a human reference population Environ Health Perspect 108 979 982 10.2307/3435058 1:CAS:528:DC%2BD3cXotVWrur4%3D
2. BC Blount KE Milgram MJ Silva NA Malek JA Reidy LL Needham JW Brock 2000 Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS Anal Chem 72 4127 4134 10.1021/ac000422r 1:CAS:528: DC%2BD3cXltVOjsb4%3D
3. AM Calafat LL Needham MJ Silva G Lambert 2004 Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit Pediatrics 113 429 434 10.1542/peds.113.5.e429
4. M Ema E Miyawaki 2001 Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy Reprod Toxicol 15 189 194 10.1016/S0890-6238(01)00111-3 1:CAS:528:DC%2BD3MXis1Sjsrs%3D (Pubitemid 32377810)
5. M Ema E Miyawaki 2001 Effects of monobutyl phthalate on reproductive function in pregnant and pseudopregnant rats Reprod Toxicol 15 261 267 10.1016/S0890-6238(01)00131-9 1:CAS:528:DC%2BD3MXktVOhsb4%3D (Pubitemid 32552932)
6. TJ Gray SD Gangolli 1986 Aspects of the testicular toxicity of phthalate esters Environ Health Perspect 65 229 235 10.2307/3430187 1:CAS:528: DyaL28XktVWrtr4%3D
7. R Green R Hauser AM Calafat J Weuve T Schettler S Ringer K Huttner H Hu 2005 Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants Environ Health Perspect 113 1222 1225 10.1289/ehp.7932 1:CAS:528: DC%2BD2MXht1agu7jF (Pubitemid 41387663)
8. R Hauser 2008 Urinary phthalate metabolites and semen quality: a review of a potential biomarker of susceptibility Int J Androl 31 112 117 10.1111/j.1365-2605.2007.00844.x 1:CAS:528:DC%2BD1cXltFCrs7g%3D
9. K Inoue M Kawaguchi R Yamanaka T Higuchi R Ito K Saito H Nakazawa 2005 Evaluation and analysis of exposure levels of di(2-ethylhexyl) phthalate from blood bags Clin Chim Acta 358 159 166 10.1016/j.cccn.2005.02.019 1:CAS:528:DC%2BD2MXmtFGjtb0%3D (Pubitemid 40966644)
10. H Itoh K Yoshida S Masunaga 2005 Evaluation of the effect of governmental control of human exposure to two phthalates in Japan using a urinary biomarker approach Int J Hyg Environ Health 208 237 245 10.1016/j.ijheh.2005.02.004 1:CAS:528:DC%2BD2MXhtFSktrjI (Pubitemid 40828892)
11. T Kawasaki K Uezono K Itoh M Ueno 1991 Prediction of 24-hour urinary creatinine excretion from age, body weight and height of an individual and its application Jpn J Public Health 38 567 574 1:STN:280:DyaK38%2FotlSmtg%3D%3D
12. HM Koch H Drexler J Angerer 2003 An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population Int J Hyg Environ Health 206 77 83 10.1078/1438-4639-00205 1:CAS:528: DC%2BD3sXjvVSgsbg%3D (Pubitemid 36356389)
13. MC Kohn F Parham SA Masten CJ Portier MD Shelby 2000 Human exposure estimates for phthalates Environ Health Perspect 108 A440 A442 10.2307/3435033 1:CAS:528:DC%2BD3cXotVWrtbo%3D
14. GK Mortensen KM Main A-M Anderson H Leffers NE Skakkebæk 2005 Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS) Anal Bioanal Chem 382 1084 1092 10.1007/s00216-005-3218-0 1:CAS:528:DC%2BD2MXlsFGms78%3D (Pubitemid 40890969)
15. E Mylchreest RC Cattley PMD Foster 1998 Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: an antiandrogenic mechanism? Toxicol Sci 43 47 60 1:CAS:528:DyaK1cXjslOqu74%3D
16. LG Parks JS Ostby CR Lambright BD Abbott GR Klinefelter NJ Barlow LE Gray Jr 2000 The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat Toxicol Sci 58 339 349 10.1093/toxsci/58.2.339 1:CAS:528: DC%2BD3cXovFynsLk%3D (Pubitemid 32042432)
17. MJ Silva DB Barr JA Reidy K Kato NA Malek CC Hodge D Hurtz 3rd AM Calafat LL Needham JW Brock 2003 Glucuronidation patterns of common urinary and serum monoester phthalate metabolites Arch Toxicol 77 561 567 10.1007/s00204-003-0486- 3 1:CAS:528:DC%2BD3sXotlajsb8%3D (Pubitemid 37378476)
18. MJ Silva DB Barr JA Reidy NA Malek CC Hodge SP Caudill JW Brock LL Needham AM Calafat 2004 Urinary levels of seven phthalate metabolites in the U.S. population from the National Health, Nutrition Examination Survey (NHANES) 1999-2000 Environ Health Perspect 112 331 338 1:CAS:528:DC%2BD2cXislaqtL4%3D
19. SH Swan KM Main F Liu SL Stewart RL Kruse AM Calafat CS Mao JB Redmon CL Ternand S Sullivan JL Teague Study for Future Families Research Team 2005 Decrease in anogenital distance among male infants with prenatal phthalate exposure Environ Health Perspect 113 1056 1061 10.1289/ehp.8100 1:CAS:528:DC%2BD2MXpslSku74%3D (Pubitemid 41149638)