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This article is a detailed review of the prognostic impact of gene mutations in AML
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This article is a meta-analysis of four prospective clinical trials describing the prognostic impact of gene mutations in AML. The analysis showed that allogeneic SCT may offer a survival advantage to AML patients, except for those with NPM1 mutation in the setting of FLT3 wild-type status.
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The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
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This article describes the prognostic impact of NPM1 mutations, FLT3-ITD mutant levels, and ITD size
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Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
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Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor
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Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
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Stirewalt DL, Kopecky KJ, Meshinchi S, et al.: Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia. Blood 2006, 107(9):3724-3726.
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The size of duplication does not add to the prognostic significance of FLT3 internal tandem duplication in acute myeloid leukemia patients
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Ponziani V, Gianfaldoni G, Mannelli F, et al.: The size of duplication does not add to the prognostic significance of FLT3 internal tandem duplication in acute myeloid leukemia patients. Leukemia 2006, 20(11):2074-2076.
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38949212204
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FLT3 D835/ I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications
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This study describes a negative prognostic impact of FLT3- TKD mutation in AML, in contrast to the findings of Mead et al. [24•].
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• Whitman SP, Ruppert AS, Radmacher MD, et al.: FLT3 D835/ I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications. Blood 2008, 111(3):1552- 1559. This study describes a negative prognostic impact of FLT3- TKD mutation in AML, in contrast to the findings of Mead et al. [24•].
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Whitman, S.P.1
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25
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34548029756
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FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia
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This article describes FLT3-TKD mutations and their favorable prognosis in AML, in contrast to the findings of Whitman et al. [23•]
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• Mead AJ, Linch DC, Hills RK, et al.: FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia. Blood 2007, 110(4):1262-1270. This article describes FLT3-TKD mutations and their favorable prognosis in AML, in contrast to the findings of Whitman et al. [23•].
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Mead, A.J.1
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Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
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Thiede C, Koch S, Creutzig E, et al.: Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 2006, 107(10):4011-4020.
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Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias
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Falini B, Nicoletti I, Bolli N, et al.: Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. Haematologica 2007, 92(4):519-532.
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Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): Biologic and clinical features
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55549103713
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Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: A Cancer and Leukemia Group B Study
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This article describes prognostic impact of CEBPa mutations in AML
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• Marcucci G, Maharry K, Radmacher MD, et al.: Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: A Cancer and Leukemia Group B Study. J Clin Oncol 2008, 26 (31):5078-5087. This article describes prognostic impact of CEBPa mutations in AML
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Marcucci, G.1
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BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: A Cancer and Leukemia Group B Study
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Baldus CD, Tanner SM, Ruppert AS, et al.: BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: A Cancer and Leukemia Group B Study. Blood 2003, 102(5):1613-1618.
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33644830601
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Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: A Cancer and Leukemia Group B study
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Marcucci G, Baldus CD, Ruppert AS, et al.: Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. J Clin Oncol 2005, 23(36):9234-9242.
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High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B Study
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This study describes the negative prognostic impact of ERG overexpression in AML
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• Marcucci G, Maharry K, Whitman SP, et al.: High expression levels of the ETS-related gene, ERG, predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B Study. J Clin Oncol 2007, 25(22):3337-3343. This study describes the negative prognostic impact of ERG overexpression in AML.
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Prognostic importance of MN1 transcript levels, and biologic insights from MN1- associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
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Langer C, Marcucci G, Holland KB, et al.: Prognostic importance of MN1 transcript levels, and biologic insights from MN1- associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2009, 27(19):3198-3204.
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ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: A comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays
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Metzeler KH, Dufour A, Benthaus T, et al.: ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays. J Clin Oncol 2009, 27(30):5031-5038.
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The MLL partial tandem duplication: Evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy
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Whitman SP, Liu S, Vukosavljevic T, et al.: The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy. Blood 2005, 106(1):345-352.
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Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: A Cancer and Leukemia Group B study
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This study shows an improved prognosis of AML patients with Ras mutations receiving high-dose cytarabine in consolidation, when compared with lower-dose cytarabine or patients with wild-type Ras AML
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• Neubauer A, Maharry K, Mrozek K, et al.: Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: a Cancer and Leukemia Group B study. J Clin Oncol 2008, 26(28):4603-4609. This study shows an improved prognosis of AML patients with Ras mutations receiving high-dose cytarabine in consolidation, when compared with lower-dose cytarabine or patients with wild-type Ras AML.
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J Clin Oncol
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Increased C-kit intensity is a poor prognostic factor for progression-free and overall survival in patients with newly diagnosed AML
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Advani AS, Rodriguez C, Jin T, et al.: Increased C-kit intensity is a poor prognostic factor for progression-free and overall survival in patients with newly diagnosed AML. Leuk Res 2008, 32(6):913-918.
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Prognostic impact of c-KIT mutations in core binding factor leukemias: An Italian retrospective study
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Cairoli R, Beghini A, Grillo G, et al.: Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study. Blood 2006, 107(9):3463-3468.
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Incidence and prognostic impact of c-Kit,FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML)
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Boissel N, Leroy H, Brethon B, et al.: Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML). Leukemia 2006, 20 (6):965-970.
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53749101166
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Wilms'tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
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This study describes the negative prognostic impact of WT1 mutations in AML
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• Paschka P, Marcucci G, Ruppert AS, et al.: Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2008, 26(28):4595-4602. This study describes the negative prognostic impact of WT1 mutations in AML.
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J Clin Oncol
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Paschka, P.1
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63349108695
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Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia
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