Sex differences in the effects of maternal vitamin supplements on mortality and morbidity among children born to HIV-infected women in Tanzania

British Journal of Nutrition

Volumn 103, Issue 12, 2010, Pages 1784-1791

  Kawai, Kosuke ^a   Msamanga, Gernard ^b   Manji, Karim ^b   Villamor, Eduardo ^a   Bosch, Ronald J ^a   Hertzmark, Ellen ^a   Fawzi, Wafaie W ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

Author keywords

Child mortality; HIV; Multivitamins; Sex; Vitamin A

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CYANOCOBALAMIN; FOLIC ACID; MULTIVITAMIN; NICOTINIC ACID; PLACEBO; PYRIDOXINE; RETINOL; RIBOFLAVIN; THIAMINE; VITAMIN B GROUP; VITAMIN;

ADULT; ARTICLE; CHILD; CHILDHOOD DISEASE; CHILDHOOD MORTALITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; FEMALE; FETUS; HEREDITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNITY; INFECTION RISK; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MATERNAL NUTRITION; PATIENT COMPLIANCE; PREGNANCY OUTCOME; PREGNANT WOMAN; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SEX DIFFERENCE; TANZANIA; VERTICAL TRANSMISSION; VIRUS TRANSMISSION; VITAMIN SUPPLEMENTATION; DIET SUPPLEMENTATION; DISEASE TRANSMISSION; HUMAN IMMUNODEFICIENCY VIRUS 1; INFANT MORTALITY; NEWBORN; PREGNANCY; PREGNANCY COMPLICATION; RISK FACTOR;

ADULT; DIARRHEA; DIETARY SUPPLEMENTS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT MORTALITY; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RISK FACTORS; SEX FACTORS; TANZANIA; VITAMINS; YOUNG ADULT;

EID: 77954617285     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509993862     Document Type: Article

References (36)

1. Fawzi WW, Chalmers TC, Herrera MG, et al. (1993) Vitamin A supplementation and child mortality. A meta-analysis. JAMA 269, 898-903.
2. Villamor E & Fawzi WW (2000) Vitamin A supplementation: implications for morbidity and mortality in children. J Infect Dis 182, SUPPL. 1, S122-S133.
3. Bhutta ZA, Ahmed T, Black RE, et al. (2008) What works? Interventions for maternal and child undernutrition and survival. Lancet 371, 417-440.
4. Gogia S & Sachdev HS (2009) Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials. BMJ 338, b919.
5. Benn CS, Fisker AB, Diness BR, et al. (2006) Neonatal vitamin a supplementation: sex-differential effects on mortality? J Infect Dis 194, 719.
6. Humphrey JH, Agoestina T, Wu L, et al. (1996) Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr 128, 489-496.
7. Rahmathullah L, Tielsch JM, Thulasiraj RD, et al. (2003) Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ 327, 254.
8. Benn CS, Diness BR, Roth A, et al. (2008) Effect of 50,000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial. BMJ 336, 1416-1420.
9. Benn CS, Martins C, Rodrigues A, et al. (2005) Randomised study of effect of different doses of vitamin A on childhood morbidity and mortality. BMJ 331, 1428-1432.
10. Yassai MB & Malek F (1989) Newborns vitamin A in relation to sex and birth weight. J Trop Pediatr 35, 247-249.
11. Benn CS, Bale C, Sommerfelt H, et al. (2003) Hypothesis: vitamin A supplementation and childhood mortality: amplification of the non-specific effects of vaccines? Int J Epidemiol 32, 822-828.
12. UNAIDS (2008) Report on the Global AIDS Epidemic. Geneva: UNAIDS.
13. Fawzi WW, Msamanga GI, Hunter D, et al. (2002) Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 16, 1935-1944.
14. \+ cell counts. Clin Infect Dis 36, 1053-1062.
15. Fawzi WW, Msamanga GI, Spiegelman D, et al. (1998) Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 351, 1477-1482.
16. World Health Organization (1993) Proposed 'World Health Organization staging system for HIV infection and disease': preliminary testing by an international collaborative cross-sectional study. The WHO International Collaborating Group for the Study of the WHO Staging System. AIDS 7, 711-718.
17. De Leenheer AP, De Bevere VO, De Ruyter MG, et al. (1979) Simultaneous determination of retinol and alpha-tocopherol in human serum by high-performance liquid chromatography. J Chromatogr 162, 408-413.
18. Baylin A, Villamor E, Rifai N, et al. (2005) Effect of vitamin supplementation to HIV-infected pregnant women on the micro-nutrient status of their infants. Eur J Clin Nutr 59, 960-968.
19. Brenner WE, Edelman DA & Hendricks CH (1976) A standard of fetal growth for the United States of America. Am J Obstet Gynecol 126, 555-564.
20. Humphrey JH, Iliff PJ, Marinda ET, et al. (2006) Effects of a single large dose of vitamin A, given during the postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality. J Infect Dis 193, 860-871.
21. Osrin D, Vaidya A, Shrestha Y, et al. (2005) Effects of antenatal multiple micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial. Lancet 365, 955-962.
22. Friis H, Gomo E, Nyazema N, et al. (2004) Effect of multimi-cronutrient supplementation on gestational length and birth size: a randomized, placebo-controlled, double-blind effectiveness trial in Zimbabwe. Am J Clin Nutr 80, 178-184.
23. Fawzi WW, Msamanga GI, Urassa W, et al. (2007) Vitamins and perinatal outcomes among HIV-negative women in Tanzania. N Engl J Med 356, 1423-1431. (Pubitemid 46556327)
24. Kourtis AP, Ibegbu C, Nahmias AJ, et al. (1996) Early progression of disease in HIV-infected infants with thymus dysfunction. N Engl J Med 335, 1431-1436.
25. Aaby P, Marx C, Trautner S, et al. (2002) Thymus size at birth is associated with infant mortality: a community study from Guinea-Bissau. Acta Paediatr 91, 698-703.
26. Garly ML, Trautner SL, Marx C, et al. (2008) Thymus size at 6 months of age and subsequent child mortality. J Pediatr 153, 683-688.
27. Chandra RK (1981) Serum thymic hormone activity and cell-mediated immunity in healthy neonates, preterm infants, and small-for-gestational age infants. Pediatrics 67, 407-411.
28. Wei R, Msamanga GI, Spiegelman D, et al. (2004) Association between low birth weight and infant mortality in children born to human immunodeficiency virus 1-infected mothers in Tanzania. Pediatr Infect Dis J 23, 530-535.
29. Lee HH, Hoeman CM, Hardaway JC, et al. (2008) Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity. J Exp Med 205, 2269-2280.
30. Levy O (2007) Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol 7, 379-390.
31. Wintergerst ES, Maggini S & Hornig DH (2007) Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 51, 301-323.
32. Long KZ & Santos JI (1999) Vitamins and the regulation of the immune response. Pediatr Infect Dis J 18, 283-290.
33. Garenne M & Lafon M (1998) Sexist diseases. Perspect Biol Med 41, 176-189.
34. Verthelyi D (2001) Sex hormones as immunomodulators in health and disease. Int Immunopharmacol 1, 983-993.
35. Beagley KW & Gockel CM (2003) Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone. FEMS Immunol Med Microbiol 38, 13-22.
36. Fawzi WW, Msamanga GI, Spiegelman D, et al. (2004) A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med 351, 23-32.