Pica in pregnancy: New ideas about an old condition

Annual Review of Nutrition

Volumn 30, Issue , 2010, Pages 403-422

  Young, Sera L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

amylophagy; detoxification; geophagy; micronutrient deficiency; pagophagy; supplementation

Indexed keywords

CALCIUM; ICE; IRON; STARCH; TRACE ELEMENT; ZINC;

ASH; CAUSAL ATTRIBUTION; CULTURAL FACTOR; DETOXIFICATION; DISEASE ASSOCIATION; DYSPEPSIA; FOOD INTAKE; HUMAN; HUNGER; IRON DEFICIENCY; MENTAL STRESS; NUTRITIONAL DEFICIENCY; NUTRITIONAL DISORDER; NUTRITIONAL STATUS; PICA; PREGNANCY COMPLICATION; PREVALENCE; PRIORITY JOURNAL; REVIEW; SUPPLEMENTATION; DEFICIENCY; FEEDING BEHAVIOR; FEMALE; PREGNANCY; PUBLIC HEALTH;

FEEDING BEHAVIOR; FEMALE; HUMANS; MICRONUTRIENTS; PICA; PREGNANCY; PREVALENCE; PUBLIC HEALTH;

EID: 77954598665     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.012809.104713     Document Type: Review

References (116)

1. - 1873. News and miscellany. Med. Surg. Rep. 29:417
2. Abrahams P, Follansbee M, Hunt A, Smith B,Wragg J. 2006. Iron nutrition and possible lead toxicity: an appraisal of geophagy undertaken by pregnant women of UK Asian communities. Appl. Geochem. 21:98-108. Aetius of Amida
3. Aetius of Amida, Ricci JV. 1542 [1950]. Aetios of Amida, The Gynaecology and Obstetrics of the Sixth Century. Philadelphia, PA: Blakiston Co. 215 pp. 4.
4. American Psychiatric Association. 2000. Diagnostic and StatisticalManual ofMentalDisorders.Washington, DC: Am. Psychiatr. Assoc. 943 pp. 4th ed., text rev. 5.
5. Anderson J, Akmal M, Kittur D. 1991. Surgical complications of pica: report of a case of intestinal obstruction and a review of the literature. Am. Surg. 57:663-667
6. Anell B, Lagercrantz S. 1958. Geophagical Customs. Uppsala: Studia Ethnographica Upsaliensia. 83 pp. 7.
7. Arcasoy A, Cavdar A, Babacan E. 1978. Decreased iron and zinc absorption in Turkish children with iron deficiency and geophagia. Acta Haematol. 60:76-84
8. Barr M. 1957. Adsorption studies on clays. II. The adsorption of bacteria by activated attapulgite, halloysite, and kaolin. J. Am. Pharm. Assoc. 46:490-492
9. Bearer C. 1995. Environmental health hazards: how children are different from adults. Future Child. 5:11-26
10. Bhalla JN, Khanna PK, Srivastava JR, Sur BK, Bhalla M. 1983. Serum zinc level in pica. Indian Pediatr. 20:667-670
11. Biot PM. 1839. Note sur des matieres pierreuses emploýees a la Chine dans les temps de famine, sous le nom de Farine de Pierre. Ann. Chim. Phys. 62:215-219
12. Bithoney WG, Snyder J,Michalek J,Newberger EH. 1985. Childhood ingestions as symptoms of family distress. Am. J. Dis. Child. 139:456-459
13. Blum M, Orton C, Rose L. 1968. The effect of starch ingestion on excessive iron absorption. Ann. Intern. Med. 68:1165
14. Brown D, Juhl R. 1976. Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N. Engl. J. Med. 295:1034-1037
15. Bruhn CM, Pangborn RM. 1971. Reported incidence of pica among migrant families. J. Am. Diet. Assoc. 58:417-420
16. Cavdar A, Arcasoy A. 1972. Hematologic and biochemical studies of Turkish children with pica. A presumptive explanation for the syndrome of geophagia, iron deficiency anemia, hepatosplenomegaly and hypogonadism. Clin. Pediatr. (Phila) 11:215-223
17. Cavdar AO, Arcasoy A, Cin S, Babacan E, Gozdasoglu S. 1983. Geophagia in Turkey: iron and zinc absorption studies and response to treatment with zinc in geophagia cases. In Zinc Deficiency in Human Subjects: Proceedings of an International Symposium held in Ankara, Turkey, April 29-30, 1982, ed. A Prasad, AO Cavdar, G Brewer, P Aggett, pp. 71-97. New York: Liss
18. Celsus AC, Grieve J. 1756. Of Medicine. London:Wilson & Durham. 519 pp. 19.
19. Chen X, Yin T, He J, Ma Q, Han Z, Li L. 1985. Low levels of zinc in hair and blood, pica, anorexia, and poor growth in Chinese preschool children. Am. J. Clin. Nutr. 42:694-700
20. Chisholm JC, Martin HI. 1981. Hypozincemia, ageusia, dysosmia, and toilet tissue pica. J. Natl. Med. Assoc. 73:163-164
21. Christiani D. 1691. Dissertatio Medica de Pica. Francofurti ad Viadrum: Literis Christophori Zeitleri. 38 pp. 22.
22. Clark JD. 2001. Kalambo Falls Prehistoric Site: Volume III. London: Cambridge Univ. Press. 703 pp. 23.
23. Coltman CJ. 1969. Pagophagia and iron lack. JAMA 207:513-516
24. Cooksey N. 1995. Pica and olfactory craving of pregnancy: How deep are the secrets? Birth 22:129-137
25. Cooney DO. 1995. Activated Charcoal in Medical Applications. New York: Marcel Dekker. 596 pp. 26.
26. Corbett R, Ryan C, Weinrich S. 2003. Pica in pregnancy: Does it affect pregnancy outcomes? Am. J. Matern. Child Nurs. 28:183-89; quiz 190-191
27. Dominy N, Davoust E, Minekus M. 2004. Adaptive function of soil consumption: an in vitro study modeling the human stomach and small intestine. J. Exp. Biol. 207:319-324
28. Dreyer MJ, Chaushev PG, Gledhill RF. 2004. Biochemical investigations in geophagia. J. R. Soc. Med. 97:48
29. Edwards AA, Mathura CB, Edwards CH. 1983. Effects of maternal geophagia on infant and juvenile rats. J. Natl. Med. Assoc. 75:895-902
30. Edwards C, Johnson A, Knight E, Oyemade U, Cole O, et al. 1994. Pica in an urban environment. J. Nutr. 124:954-62S
31. Edwards CH, McDonald S, Mitchell JR, Jones L, Mason L, et al. 1959. Clay-and cornstarch-eating women. J. Am. Diet. Assoc. 35:810-815
32. Fessler D. 2002. Reproductive immunosuppression and diet. Curr. Anthropol. 43:19-60
33. Flaxman S, Sherman P. 2000. Morning sickness: a mechanism for protecting mother and embryo. Q. Rev. Biol. 75:113-148
34. Forsyth C, Benoit GM. 1989. "Rare, Old, Dirty Snacks": some research notes on dirt eating. Deviant Behav. 10:61-68
35. Frankel B. 1977. Childbirth in the Ghetto: Folk Beliefs of Negro Women in a North Philadelphia Hospital Ward. San Francisco: R & E Res. Assoc. 124 pp. 36.
36. Geissler P, Mwaniki D, Thiong F, Friis H. 1998. Geophagy as a risk factor for geohelminth infections: a longitudinal study of Kenyan primary schoolchildren. Trans. R. Soc. Trop. Med. Hyg. 92:7-11
37. Geissler P, Mwaniki D, Thiong'o F, Friis H. 1997. Geophagy among school children in western Kenya. Trop. Med. Int. Health 2:624-630
38. Geissler P, Prince R, LeveneM, Poda C, Beckerleg S, et al. 1999. Perceptions of soil-eating and anaemia among pregnant women on the Kenyan coast. Soc. Sci. Med. 48:1069-1079
39. Gilardi JD, Duffey SS, Munn CA, Tell LA. 1999. Biochemical functions of geophagy in parrots: detoxification of dietary toxins and cytoprotective effects. J. Chem. Ecol. 25:897-922
40. Glahn RP, Lee OA, Yeung A, Goldman MI, Miller DD. 1998. Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion/Caco-2 cell culture model. J. Nutr. 128:1555-1561
41. Gonzalez R, De Medina FS, Martinez-Augustin O, Nieto A, Galvez J, et al. 2004. Anti-inflammatory effect of diosmectite in hapten-induced colitis in the rat. Br. J. Pharmacol. 141:951-960
42. Grigsby R, Thyer B, Waller R, Johnston GJ. 1999. Chalk eating in middle Georgia: a culture-bound syndrome of pica? South. Med. J. 92:190-192
43. Guarino A, Lo Vecchio A, Pirozzi MR. 2009. Clinical role of diosmectite in the management of diarrhea. Expert Opin. Drug Metab. Toxicol. 5:433-440
44. Guernier V, Hochberg M, Guegan J. 2004. Ecology drives the worldwide distribution of human diseases. PLoS Biol. 2:e141
45. Gutelius MF, Millican FK, Layman EM,Cohen GC,Dublin CC. 1963. Treatment of pica with a vitamin and mineral supplement. Am. J. Clin. Nutr. 12:388-393
46. Gutelius MF, Millican FK, Layman EM, Cohen GJ, Dublin CC. 1962. Nutritional studies of children with pica. Pediatrics 29:1012-1023
47. Haydel SE,RemenihCM,WilliamsLB. 2008. Broad-spectrum in vitro antibacterial activities of clay minerals against antibiotic-susceptible and antibiotic-resistant bacterial pathogens. J. Antimicrob. Chemother. 61:353-361
48. Hertz H. 1947. Notes on clay and starch eating among Negroes in a Southern urban community. Soc. Forces 25:343-344
49. Hippocrates, Adams F. 1849. The Genuine Works of Hippocrates. London: Sydenham Soc.
50. Hladik CM, Gueguen L. 1974. Geophagie et nutrition minerale chez les primates sauvages. C. R. Acad. Sci. III, Sci. Vie 279:1393-1396
51. Hochstein G. 1968. Pica: a study in medical and anthropological explanation. In Essays on Medical Anthropology, Southern Anthropological Society Proceedings, No.1, ed. T Weaver, pp. 88-96. Athens: Univ. Georgia Press
52. Hooda PS, Henry CJ, Seyoum TA, Armstrong LD, Fowler MB. 2004. The potential impact of dietary nutrients. soil ingestion on human mineral nutrition. Sci. Total Environ. 333:75-87
53. Hopffe A. 1917. Uber infusorienerde (Bergmehl). Naturwiss. Wochenschr. 16:286-287
54. Hui Y, Smith R, Spoerke D. 2001. Foodborne Disease Handbook. Vol.3: Plant Toxicants. NewYork: Marcel Dekker
55. Hunter JM. 1973. Geophagy in Africa and in the United States: a culture-nutrition hypothesis. Geogr. Rev. 63:170-195
56. Hunter JM. 1993. Macroterme geophagy and pregnancy clays in southern Africa. J. Cult.Geogr. 14:69-92
57. Hunter JM, de Kleine R. 1984. Geophagy in Central America. Geogr. Rev. 74:157-169
58. Imray J. 1843. Observations on the mal d'estomac or cachexia Africana, as it takes place among the Negroes of Dominica. Edinb. Med. Surg. J. 59:304-321
59. Institute of Medicine. 2002. DRI: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc.Washington, DC: Natl. Acad. Press. 773 pp.
60. Ivascu N, Sarnaik S, McCrae J, Whitten-Shurney W, Thomas R, Bond S. 2001. Characterization of pica prevalence among patients with sickle cell disease. Arch. Pediatr. Adolesc. Med. 155:1243-1247
61. JacksonWC,Martin JP. 2000. Amylophagia presenting as gestational diabetes. Arch. Fam. Med. 9:649-652
62. Jenkins CL. 1980. Geophagy in Fayette County, Tennessee: a symbolic interpretation. Tenn. Anthropologist 5:73-91
63. Jiang J,He X, Cane DE. 2007. Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. Nat. Chem. Biol. 3:711-715
64. Johns T. 1986. Detoxification function of geophagy and domestication of the potato. J. Chem. Ecol. 12:635-646
65. Johns T, Duquette M. 1991. Detoxification and mineral supplementation as functions of geophagy. Am. J. Clin. Nutr. 53:448-456
66. Kalayci A, Kanber Y, Birinci A, Yildiz L, Albayrak D. 2005. The prevalence of celiac disease as detected by screening in children with iron deficiency anaemia. Acta Paediatr. 94:678-681
67. Katz J. 2008. Poor Haitians resort to eating dirt. Natl. Geographic News. Jan. 30. http://news. nationalgeographic.com/news/2008/01/080130-AP-haiti- eatin.html
68. Keith L, Bartizal F, Brown E. 1971. Controlled amylophagia in female mice. Experientia 27:847-848
69. Kendall NR, Telfer SB. 2000. Induction of zinc deficiency in sheep and its correction with a soluble glass bolus containing zinc. Vet. Rec. 146:634-637
70. Khalil SA, Daabis NA, Naggar VF, Motawi MM. 1976. The in vitro adsorption of some antibiotics on antacids. Pharmazie 31:105-109
71. Kikouama JR, Cornec FL, Bouttier S, Launay A, Balde L, Yagoubi N. 2009. Evaluation of trace elements released by edible clays in physicochemically simulated physiological media. Int. J. Food Sci. Nutr. 60:130-142
72. Kraemer S. 2002. Clay, Vicks, and Gold Medal flour. South. Med. J. 95(10):1228-1229
73. Kreulen DA. 1985. Lick use by large herbivores: a review of benefits and banes of soil consumption. Mammal. Rev. 15:107-123
74. Krishnamani R, Mahaney W. 2000. Geophagy among primates: adaptive significance and ecological consequences. Anim. Behav. 59:899-915
75. Laufer B. 1930. Geophagy. Publication 280, Anthropol. Ser. Vol.18(2). Chicago: Field Museum of Natural History
76. Lavie S, Stotzky G. 1986. Interactions between clay minerals and siderophores affect the respiration of Histoplasma capsulatum. Appl. Environ. Microbiol. 51:74-79 (Pubitemid 16149165)
77. Libnoch J. 1984. Geomelophagia. An unusual pica in iron-deficiency anemia. Am. J. Med. 76:A69
78. Lipson SM, Stotzky G. 1983. Adsorption of reovirus to clay minerals: effects of cation-exchange capacity, cation saturation, and surface area. Appl. Environ. Microbiol. 46:673-682
79. Livingstone D, Waller H. 1875. The Last Journals of David Livingstone, in Central Africa, from Eighteen Hundred and Sixty-Five to His Death. New York: Harpers & Brothers
80. Lofts R, Schroeder S,Maier R. 1990. Effects of serum zinc supplementation on pica behavior of persons with mental retardation. Am. J. Ment. Retard. 95:103-109
81. MahaneyWC, Milner MW, Hs M, Hancock R, Aufreiter S, et al. 2000. Mineral and chemical analyses of soils eaten by humans in Indonesia. Int. J. Environ. Health Res. 10:93-109
82. McDonald R, Marshall SR. 1964. The value of iron therapy in pica. Pediatrics 34:558-562
83. McElnay J, Mukhtar H, D'Arcy P, Temple D, Collier P. 1982. The effect of magnesium trisilicate and kaolin on the in vivo absorption of chloroquine. J. Trop. Med. Hyg. 85:159-163
84. McIntyre P. 2000. "That Dirt Was Good!": memories of geophagy among Alabama Black Belt tenant farmers. Tributaries 3:59-74
85. Minnich V, Okcuoglu A, Tarcon Y, Arcasoy A, Cin S, et al. 1968. Pica in Turkey. II. Effect of clay upon iron absorption. Am. J. Clin. Nutr. 21:78-86
86. Mohan M, Agarwal K, Bhutt I, Khanduja P. 1968. Iron therapy in pica. J. Indian Med. Assoc. 51:16-18
87. Moŕe J, Fioramonti J, Bueno L. 1992. Changes in gastrointestinal mucins caused by attapulgite. Experimental study in rats. Gastroenterol. Clin. Biol. 16:988-993
88. Morris MJ, Na ES, Johnson AK. 2008. Salt craving: the psychobiology of pathogenic sodium intake. Physiol. Behav. 94:709-721
89. Nchito M, Geissler PW, Mubila L, Friis H, Olsen A. 2004. Effects of iron and multimicronutrient supplementation on geophagy: a two-by-two factorial study among Zambian schoolchildren in Lusaka. Trans. R. Soc. Trop. Med. Hyg. 98:218-227
90. Nyaruhucha CN. 2009. Food cravings, aversions and pica among pregnant women in Dar es Salaam, Tanzania. Tanzan. J. Health Res. 11:29-34
91. Ofoefule SI, Okonta M. 1999. Adsorption studies of ciprofloxacin: evaluation of magnesium trisilicate, kaolin and starch as alternatives for the management of ciprofloxacin poisoning. Boll. Chim. Farm. 138:239-242
92. PhillipsT. 1999. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol. Sci. 52:118-126
93. Profet M. 1992. Pregnancy sickness as adaptation: a deterrent to maternal ingestion of teratogens. In The Adapted Mind: Evolutionary Psychology and the Generation of Culture, ed. JH Barkow, L Cosmides, J Tooby, pp. 327-366 New York: Oxford Univ. Press
94. Reynolds R, Binder H, Miller M, Chang W, Horan S. 1968. Pagophagia and iron deficiency anemia. Ann. Intern. Med. 69:435-440
95. Rogers ME. 1972. Practice of Pica Among Iron Deficient Pregnant Women. Master's thesis. Auburn Univ., Auburn, AL. 81 pp.
96. Sayers G, Lipschitz D, Sayers M, Sefterl H, Bothwell T, Charlton R. 1974. Relationship between pica and iron nutrition in Johannesburg black adults. S. Afr. Med. J. 48:1655-1660
97. Shannon M. 2003. Severe lead poisoning in pregnancy. Ambul. Pediatr. 3:37-39
98. Smith B, Rawlins B, CordeiroM,HutchinsM, Tiberindwa J, et al. 2000. The bioaccessibility of essential and potentially toxic trace elements in tropical soils from Mukono District, Uganda. J. Geol. Soc. London 157:885-891
99. Smith JC, Halsted JA. 1970. Clay ingestion (geophagia) as a source of zinc for rats. J. Nutr. 100:973-980
100. Takeda N, Hasegawa S, Morita M, Matsunaga T. 1993. Pica in rats is analogous to emesis: an animal model in emesis research. Pharmacol. Biochem. Behav. 45:817-821
101. Talkington KM, Gant NF, Scott DE, Pritchard JA. 1970. Effect of ingestion of starch and some clays on iron absorption. Am. J. Obstet. Gynecol. 108:262-267
102. Tandu-Umba N, Paluku M. 1988. Risque nutrionnel de la population obstetricale aux cliniques universitaires de Kinshasa. Ḿed. Nutr. 24:178-180
103. Thomas FB, Falko JM, Zuckerman K. 1976. Inhibition of intestinal iron absorption by laundry starch. Gastroenterology 71:1028-1032
104. Vermeer D, Frate D. 1979. Geophagia in rural Mississippi: environmental and cultural contexts and nutritional implications. Am. J. Clin. Nutr. 32:2129-2135
105. Vermeer DE. 1966. Geophagy among the Tiv of Nigeria. Ann. Assoc. Am. Geogr. 56:197-204
106. von Humboldt A, Bonpland A, Williams HM. 1821. Personal Narrative of Travels to the Equinoctial Regions of the New Continent During the Years 1799-1804. Volume 5. Paris: Longman, Hurst, Rees, Orme, & Brown
107. Ward P, Kutner NG. 1999. Reported pica behavior in a sample of incident dialysis patients. J. Ren. Nutr. 9:14-20
108. Wiley AS, Katz SH. 1998. Geophagy in pregnancy: a test of a hypothesis. Curr. Anthropol. 39:532-545
109. Wilson M. 2003. Clay mineralogical and related characteristics of geophagic materials. J. Chem. Ecol. 29:1525-1547
110. World Health Org. 1992. The ICD-10Classification ofMental and BehaviouralDisorders: Clinical Descriptions and Diagnostic Guidelines. Geneva:World Health Org. 362 pp.
111. Youdim MB, Iancu TC. 1977. Pica hypothesis. Br. J. Haematol. 36:298
112. Young S, Ali S. 2005. Linking traditional treatments of maternal anaemia to iron supplement use: an ethnographic case study from Pemba Island, Zanzibar. Matern. Child Nutr. 1:51-58
113. Young S, Wilson M, Miller D, Hillier S. 2008. Toward a comprehensive approach to the collection and analysis of pica substances, with emphasis on geophagic materials. PLoS ONE 3:e3147
114. Young SL, Goodman D, Farag T, Ali S, Khatib M, et al. 2007. Geophagia is not associated with Trichuris or hookworm transmission in Zanzibar, Tanzania. Trans. R. Soc. Trop. Med. Hyg. 101:766-772
115. Young SL, Khalfan S, Farag T, Kavle T, Ali S, et al. 2010. Pica is associated with anemia and gastrointestinal distress among pregnant Zanzibari women. Am. J. Trop. Med. Hyg. In press
116. Young SL, Wilson MJ,Hillier S, Delbos E, Ali SM, Stoltzfus R. 2010. Differences and commonalities in physical, chemical, and mineralogical properties of Zanzibari geophagic soils. J. Chem. Ecol. 36:129-140